ZN616_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN616_HUMAN
• UniProt AC: Q08AN1
• Protein Name: Zinc finger protein 616
• Gene Name: ZNF616
• Organism: Homo sapiens (Human).
• Sequence Length: 781
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MATQGHLTFKDVAIEFSQEEWKCLEPVQKALYKDVMLENYRNLVFLGISPKCVIKELPPTENSNTGERFQTVALERHQSYDIENLYFREIQKHLHDLEFQWKDGETNDKEVPVPHENNLTGKRDQHSQGDVENNHIENQLTSNFESRLAELQKVQTEGRLYECNETEKTGNNGCLVSPHIREKTYVCNECGKAFKASSSLINHQRIHTTEKPYKCNECGKAFHRASLLTVHKVVHTRGKSYQCDVCGKIFRKNSYFVRHQRSHTGQKPYICNECGKSFSKSSHLAVHQRIHTGEKPYKCNLCGKSFSQRVHLRLHQTVHTGERPFKCNECGKTFKRSSNLTVHQVIHAGKKPYKCDVCGKAFRHRSNLVCHRRIHSGEKQYKCNECGKVFSKRSSLAVHRRIHTVEKPCKCNECGKVFSKRSSLAVHQRIHTGQKTYKCNKCGKVYSKHSHLAVHWRIHTGEKAYKCNECGKVFSIHSRLAAHQRIHTGEKPYKCNECGKVFSQHSRLAVHRRIHTGEKPYKCKECGKVFSDRSAFARHRRIHTGEKPYKCKECGKVFSQCSRLTVHRRIHSGEKPYKCNECGKVYSQYSHLVGHRRVHTGEKPYKCHECGKAFNQGSTLNRHQRIHTGEKPYKCNQCGNSFSQRVHLRLHQTVHTGDRPYKCNECGKTFKRSSNLTAHQIIHAGKKPYKCDECGKVFRHSSHLVSHQRIHTGEKRYKCIECGKAFGRLFSLSKHQRIHSGKKPYKCNECGKSFICRSGLTKHRIRHTGESLTTKLNVTRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	KDVAIEFSQEEWKCL HHEEEEECHHHHHHC	24.72	27251275
33	Ubiquitination	PVQKALYKDVMLENY HHHHHHHHHHHHHHC	44.70	-
49	Phosphorylation	NLVFLGISPKCVIKE CEEEEECCCCEEEEE	19.26	29396449
79	Phosphorylation	VALERHQSYDIENLY EEEHHCCCCCHHHHH	20.74	24173317
80	Phosphorylation	ALERHQSYDIENLYF EEHHCCCCCHHHHHH	17.86	28450419
127	Phosphorylation	TGKRDQHSQGDVENN CCCCCCCCCCCHHCC	30.17	-
161	Phosphorylation	VQTEGRLYECNETEK HHCCCCEEECCCCEE	19.64	25690035
166	Phosphorylation	RLYECNETEKTGNNG CEEECCCCEECCCCC	28.88	30377224
168	Acetylation	YECNETEKTGNNGCL EECCCCEECCCCCCE	69.97	26051181
177	Phosphorylation	GNNGCLVSPHIREKT CCCCCEECHHHHCCE	9.60	25159151
195	Ubiquitination	NECGKAFKASSSLIN CCHHHHHHHCHHHHC	52.82	29967540
198	Phosphorylation	GKAFKASSSLINHQR HHHHHHCHHHHCCCC	33.74	23403867
199	Phosphorylation	KAFKASSSLINHQRI HHHHHCHHHHCCCCC	30.67	23403867
214	Sumoylation	HTTEKPYKCNECGKA CCCCCCEECCCCHHH	38.83	-
214	Sumoylation	HTTEKPYKCNECGKA CCCCCCEECCCCHHH	38.83	-
277	Phosphorylation	ICNECGKSFSKSSHL EECCCCCCCCCCCCE	21.75	24719451
280	Sumoylation	ECGKSFSKSSHLAVH CCCCCCCCCCCEEHH	54.70	-
280	Sumoylation	ECGKSFSKSSHLAVH CCCCCCCCCCCEEHH	54.70	-
292	Phosphorylation	AVHQRIHTGEKPYKC EHHCCHHCCCCCEEC	44.67	29496963
297	Phosphorylation	IHTGEKPYKCNLCGK HHCCCCCEECCCCCC	38.96	-
307	Phosphorylation	NLCGKSFSQRVHLRL CCCCCCHHHHHHHEE	24.94	-
317	Phosphorylation	VHLRLHQTVHTGERP HHHEEECEECCCCCC	11.96	28555341
320	Phosphorylation	RLHQTVHTGERPFKC EEECEECCCCCCEEC	36.08	28555341
388	Acetylation	YKCNECGKVFSKRSS EEECCCCCEEECCHH	52.33	24884039
392	Acetylation	ECGKVFSKRSSLAVH CCCCEEECCHHHHHH	44.85	24884045
423	Phosphorylation	KVFSKRSSLAVHQRI CEEECCCCHHHHHHH	25.12	25003641
435	Methylation	QRIHTGQKTYKCNKC HHHCCCCCEEEECCC	55.99	-
435	"N6,N6-dimethyllysine"	QRIHTGQKTYKCNKC HHHCCCCCEEEECCC	55.99	-
438	Methylation	HTGQKTYKCNKCGKV CCCCCEEEECCCCCE	36.24	-
438	"N6,N6-dimethyllysine"	HTGQKTYKCNKCGKV CCCCCEEEECCCCCE	36.24	-
488	Phosphorylation	AAHQRIHTGEKPYKC HHHCCHHCCCCCEEC	44.67	29496963
493	Phosphorylation	IHTGEKPYKCNECGK HHCCCCCEECCCCCC	38.96	18767875
494	Sumoylation	HTGEKPYKCNECGKV HCCCCCEECCCCCCC	38.83	-
494	Sumoylation	HTGEKPYKCNECGKV HCCCCCEECCCCCCC	38.83	-
516	Phosphorylation	AVHRRIHTGEKPYKC HHHCCCCCCCCCEEC	44.67	29496963
521	Phosphorylation	IHTGEKPYKCKECGK CCCCCCCEECCCCCC	39.83	-
523	S-palmitoylation	TGEKPYKCKECGKVF CCCCCEECCCCCCEE	3.56	29575903
526	S-palmitoylation	KPYKCKECGKVFSDR CCEECCCCCCEECCH	3.80	29575903
544	Phosphorylation	ARHRRIHTGEKPYKC HHHCCCCCCCCCCCC	44.67	29496963
549	Phosphorylation	IHTGEKPYKCKECGK CCCCCCCCCCCCCHH	39.83	-
572	Phosphorylation	TVHRRIHSGEKPYKC EECCCCCCCCCCEEC	46.40	29496963
578	Sumoylation	HSGEKPYKCNECGKV CCCCCCEECCCCCHH	38.83	-
578	Sumoylation	HSGEKPYKCNECGKV CCCCCCEECCCCCHH	38.83	-
600	Phosphorylation	VGHRRVHTGEKPYKC HCCCCCCCCCCCEEH	44.15	29496963
603	Ubiquitination	RRVHTGEKPYKCHEC CCCCCCCCCEEHHCC	55.80	-
603	Sumoylation	RRVHTGEKPYKCHEC CCCCCCCCCEEHHCC	55.80	-
603	Sumoylation	RRVHTGEKPYKCHEC CCCCCCCCCEEHHCC	55.80	-
628	Phosphorylation	NRHQRIHTGEKPYKC CCCCCCCCCCCCCCC	44.67	29496963
653	Phosphorylation	VHLRLHQTVHTGDRP HHHEEECEECCCCCC	11.96	28555341
656	Phosphorylation	RLHQTVHTGDRPYKC EEECEECCCCCCEEE	36.12	28555341
662	Sumoylation	HTGDRPYKCNECGKT CCCCCCEEECCCCCC	33.01	-
662	Sumoylation	HTGDRPYKCNECGKT CCCCCCEEECCCCCC	33.01	-
718	Sumoylation	HTGEKRYKCIECGKA ECCCCEEEEEHHHHH	32.54	-
740	Phosphorylation	SKHQRIHSGKKPYKC CCCCCCCCCCCCEEC	50.35	-
745	Phosphorylation	IHSGKKPYKCNECGK CCCCCCCEECCCCCC	36.73	-
746	Sumoylation	HSGKKPYKCNECGKS CCCCCCEECCCCCCE	38.83	-
746	Sumoylation	HSGKKPYKCNECGKS CCCCCCEECCCCCCE	38.83	-
753	Phosphorylation	KCNECGKSFICRSGL ECCCCCCEEECCCCC	12.72	24719451
768	Phosphorylation	TKHRIRHTGESLTTK CCCCCCCCCCCCEEE	32.56	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN616_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN616_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN616_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZN616_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.