TALD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TALD3_HUMAN
• UniProt AC: Q9BVV6
• Protein Name: Protein TALPID3
• Gene Name: KIAA0586
• Organism: Homo sapiens (Human).
• Sequence Length: 1533
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Photoreceptor inner segment . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, cilium basal body . Forms a ring-like structur
• Protein Description: Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation. [PubMed: 24421332 Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity]
• Protein Sequence: MPVKRLREVVSQNHGDHLVLLKDELPCVPPALSANKRLPVGTGTSLNGTSRGSSDLTSARNCYQPLLENPMVSESDFSKDVAVQVLPLDKIEENNKQKANDIFISQYTMGQKDALRTVLKQKAQSMPVFKEVKVHLLEDAGIEKDAVTQETRISPSGIDSATTVAAATAAAIATAAPLIKVQSDLEAKVNSVTELLSKLQETDKHLQRVTEQQTSIQRKQEKLHCHDHEKQMNVFMEQHIRHLEKLQQQQIDIQTHFISAALKTSSFQPVSMPSSRAVEKYSVKPEHPNLGSCNPSLYNTFASKQAPLKEVEDTSFDKQKSPLETPAPRRFAPVPVSRDDELSKRENLLEEKENMEVSCHRGNVRLLEQILNNNDSLTRKSESSNTTSLTRSKIGWTPEKTNRFPSCEELETTKVTMQKSDDVLHDLGQKEKETNSMVQPKESLSMLKLPDLPQNSVKLQTTNTTRSVLKDAEKILRGVQNNKKVLEENLEAIIRAKDGAAMYSLINALSTNREMSEKIRIRKTVDEWIKTISAEIQDELSRTDYEQKRFDQKNQRTKKGQNMTKDIRTNTQDKTVNKSVIPRKHSQKQIEEHFRNLPMRGMPASSLQKERKEGLLKATTVIQDEDYMLQVYGKPVYQGHRSTLKKGPYLRFNSPSPKSRPQRPKVIERVKGTKVKSIRTQTDFYATKPKKMDSKMKHSVPVLPHGDQQYLFSPSREMPTFSGTLEGHLIPMAILLGQTQSNSDTMPPAGVIVSKPHPVTVTTSIPPSSRKVETGVKKPNIAIVEMKSEKKDPPQLTVQVLPSVDIDSISNSSADVLSPLSSPKEASLPPVQTWIKTPEIMKVDEEEVKFPGTNFDEIIDVIQEEEKCDEIPDSEPILEFNRSVKADSTKYNGPPFPPVASTFQPTADILDKVIERKETLENSLIQWVEQEIMSRIISGLFPVQQQIAPSISVSVSETSEPLTSDIVEGTSSGALQLFVDAGVPVNSNVIKHFVNEALAETIAVMLGDREAKKQGPVATGVSGDASTNETYLPARVCTPLPTPQPTPPCSPSSPAKECVLVKTPDSSPCDSDHDMAFPVKEICAEKGDDMPAIMLVNTPTVTPTTTPPPAAAVFTPTLSDISIDKLKVSSPELPKPWGDGDLPLEEENPNSPQEELHPRAIVMSVAKDEEPESMDFPAQPPPPEPVPFMPFPAGTKAPSPSQMPGSDSSTLESTLSVTVTETETLDKPISEGEILFSCGQKLAPKILEDIGLYLTNLNDSLSSTLHDAVEMEDDPPSEGQVIRMSHKKFHADAILSFAKQNQESAVSQQAVYHSEDLENSVGELSEGQRPQLTAAAENILMGHSLYMQPPVTNTQSLDQQCDPKPLSRQFDTVSGSIYEDSCASHGPMSLGELELEPNSKLVLPTTLLTAQENDVNLPVAAEDFSQYQLKQNQDVKQVEHKPSQSYLRVRNKSDIAPSQQQVSPGDMDRTQIELNPYLTCVFSGGKAVPLSASQMPPAKMSVMLPSVNLEDCSQSLSLSTMQEDMESSGADTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4 (in isoform 2)	Phosphorylation	-		30206219
7 (in isoform 2)	Phosphorylation	-		30206219
16 (in isoform 3)	Phosphorylation	-		30206219
19 (in isoform 3)	Phosphorylation	-		30206219
73	Phosphorylation	LLENPMVSESDFSKD HHHCCCCCHHHCCCC		27251275
78	Phosphorylation	MVSESDFSKDVAVQV CCCHHHCCCCCEEEE		-
81 (in isoform 4)	Phosphorylation	-		22210691
82 (in isoform 4)	Phosphorylation	-		22210691
85 (in isoform 4)	Phosphorylation	-		26552605
88 (in isoform 4)	Phosphorylation	-		26552605
89 (in isoform 4)	Phosphorylation	-		26552605
90 (in isoform 3)	Phosphorylation	-		27642862
92 (in isoform 4)	Phosphorylation	-		26552605
96 (in isoform 4)	Phosphorylation	-		26552605
125	Phosphorylation	VLKQKAQSMPVFKEV HHHHHHHHCCCCEEE		28348404
144	Ubiquitination	LEDAGIEKDAVTQET HHHCCCCCCCCCCCE		-
154	Phosphorylation	VTQETRISPSGIDSA CCCCEEECCCCCCHH		25159151
156	Phosphorylation	QETRISPSGIDSATT CCEEECCCCCCHHHH		29496963
160	Phosphorylation	ISPSGIDSATTVAAA ECCCCCCHHHHHHHH		26434776
162	Phosphorylation	PSGIDSATTVAAATA CCCCCHHHHHHHHHH		26434776
163	Phosphorylation	SGIDSATTVAAATAA CCCCHHHHHHHHHHH		26434776
168	Phosphorylation	ATTVAAATAAAIATA HHHHHHHHHHHHHHH		27251275
178 (in isoform 3)	Phosphorylation	-		22210691
179 (in isoform 3)	Phosphorylation	-		22210691
182 (in isoform 3)	Phosphorylation	-		26552605
183	Phosphorylation	APLIKVQSDLEAKVN HHHHHHHHHHHHHHH		26657352
185 (in isoform 3)	Phosphorylation	-		26552605
186 (in isoform 3)	Phosphorylation	-		26552605
188	Ubiquitination	VQSDLEAKVNSVTEL HHHHHHHHHHHHHHH		-
189 (in isoform 3)	Phosphorylation	-		26552605
191	Phosphorylation	DLEAKVNSVTELLSK HHHHHHHHHHHHHHH		-
193 (in isoform 3)	Phosphorylation	-		26552605
198	Ubiquitination	SVTELLSKLQETDKH HHHHHHHHHHHHHHH		-
198 (in isoform 2)	Phosphorylation	-		24719451
204	Ubiquitination	SKLQETDKHLQRVTE HHHHHHHHHHHHHHH		-
214	Phosphorylation	QRVTEQQTSIQRKQE HHHHHHHHHHHHHHH		26434776
215	Phosphorylation	RVTEQQTSIQRKQEK HHHHHHHHHHHHHHH		26434776
224 (in isoform 3)	Phosphorylation	-		27251275
251 (in isoform 3)	Phosphorylation	-		27251275
264	Phosphorylation	FISAALKTSSFQPVS HHHHHHHCCCCCCCC		26552605
265	Phosphorylation	ISAALKTSSFQPVSM HHHHHHCCCCCCCCC		26552605
266	Phosphorylation	SAALKTSSFQPVSMP HHHHHCCCCCCCCCC		26552605
271	Phosphorylation	TSSFQPVSMPSSRAV CCCCCCCCCCCCCCC		26552605
274	Phosphorylation	FQPVSMPSSRAVEKY CCCCCCCCCCCCCEE		26552605
275	Phosphorylation	QPVSMPSSRAVEKYS CCCCCCCCCCCCEEC		26552605
304	Ubiquitination	LYNTFASKQAPLKEV HHHHHHCCCCCCCCC		-
321	Phosphorylation	TSFDKQKSPLETPAP CCCCCCCCCCCCCCC		21815630
325	Phosphorylation	KQKSPLETPAPRRFA CCCCCCCCCCCCCCC		28102081
343	Phosphorylation	VSRDDELSKRENLLE CCCCHHHHHHHHHHH		-
352	Ubiquitination	RENLLEEKENMEVSC HHHHHHHHHHCCCCC		-
358	Phosphorylation	EKENMEVSCHRGNVR HHHHCCCCCCHHHHH		-
376	Phosphorylation	QILNNNDSLTRKSES HHHHCCCCCCCCCCC		28555341
378	Phosphorylation	LNNNDSLTRKSESSN HHCCCCCCCCCCCCC		28348404
380	Ubiquitination	NNDSLTRKSESSNTT CCCCCCCCCCCCCCC		17370265
389 (in isoform 3)	Phosphorylation	-		27251275
393	Ubiquitination	TTSLTRSKIGWTPEK CCCCCHHHCCCCCCC		-
397	Phosphorylation	TRSKIGWTPEKTNRF CHHHCCCCCCCCCCC		22199227
400	Ubiquitination	KIGWTPEKTNRFPSC HCCCCCCCCCCCCCH		-
401	Phosphorylation	IGWTPEKTNRFPSCE CCCCCCCCCCCCCHH		30108239
406	Phosphorylation	EKTNRFPSCEELETT CCCCCCCCHHHHCCC		30576142
412	Phosphorylation	PSCEELETTKVTMQK CCHHHHCCCEEEEEC		30108239
413	Phosphorylation	SCEELETTKVTMQKS CHHHHCCCEEEEECC		30576142
414	Ubiquitination	CEELETTKVTMQKSD HHHHCCCEEEEECCH		-
421 (in isoform 2)	Phosphorylation	-		24719451
443	Phosphorylation	SMVQPKESLSMLKLP CCCCCHHHHHCCCCC		28111955
445	Phosphorylation	VQPKESLSMLKLPDL CCCHHHHHCCCCCCC		28111955
448	Ubiquitination	KESLSMLKLPDLPQN HHHHHCCCCCCCCCC		-
456	Phosphorylation	LPDLPQNSVKLQTTN CCCCCCCCEEEECCC		28111955
458	Ubiquitination	DLPQNSVKLQTTNTT CCCCCCEEEECCCCH		-
461	Phosphorylation	QNSVKLQTTNTTRSV CCCEEEECCCCHHHH		29978859
462	Phosphorylation	NSVKLQTTNTTRSVL CCEEEECCCCHHHHH		29978859
464	Phosphorylation	VKLQTTNTTRSVLKD EEEECCCCHHHHHHH		29978859
465	Phosphorylation	KLQTTNTTRSVLKDA EEECCCCHHHHHHHH		29978859
467	Phosphorylation	QTTNTTRSVLKDAEK ECCCCHHHHHHHHHH		29978859
469 (in isoform 3)	Phosphorylation	-		27251275
474 (in isoform 3)	Phosphorylation	-		27251275
484	Ubiquitination	RGVQNNKKVLEENLE HHHHCCHHHHHHHHH		-
497	Ubiquitination	LEAIIRAKDGAAMYS HHHHHHCCCHHHHHH		-
503	Phosphorylation	AKDGAAMYSLINALS CCCHHHHHHHHHHHH		24719451
510	Phosphorylation	YSLINALSTNREMSE HHHHHHHHCCHHHHH		24719451
516	Phosphorylation	LSTNREMSEKIRIRK HHCCHHHHHHHHHHH		24719451
518 (in isoform 2)	Phosphorylation	-		24719451
523	Ubiquitination	SEKIRIRKTVDEWIK HHHHHHHHHHHHHHH		-
525 (in isoform 2)	Phosphorylation	-		24719451
531 (in isoform 2)	Phosphorylation	-		24719451
565	Ubiquitination	KKGQNMTKDIRTNTQ HCCCCCCCHHHHCCC		-
569	Phosphorylation	NMTKDIRTNTQDKTV CCCCHHHHCCCCCCC		30576142
571	Phosphorylation	TKDIRTNTQDKTVNK CCHHHHCCCCCCCCH		30576142
588	Ubiquitination	IPRKHSQKQIEEHFR CCCCCCHHHHHHHHH		-
593 (in isoform 2)	Phosphorylation	-		24719451
595 (in isoform 2)	Phosphorylation	-		24719451
605	Phosphorylation	PMRGMPASSLQKERK CCCCCCHHHHHHHHH		16674116
606	Phosphorylation	MRGMPASSLQKERKE CCCCCHHHHHHHHHC		16674116
609	Ubiquitination	MPASSLQKERKEGLL CCHHHHHHHHHCCCC		-
634	Ubiquitination	YMLQVYGKPVYQGHR CEEEECCCEEECCCH		-
654	Phosphorylation	GPYLRFNSPSPKSRP CCCCCCCCCCCCCCC		22199227
656	Phosphorylation	YLRFNSPSPKSRPQR CCCCCCCCCCCCCCC		22199227
659	Phosphorylation	FNSPSPKSRPQRPKV CCCCCCCCCCCCCHH		-
685	Phosphorylation	IRTQTDFYATKPKKM EEECCCCCCCCCCCC		-
687	Phosphorylation	TQTDFYATKPKKMDS ECCCCCCCCCCCCCC		-
688	Ubiquitination	QTDFYATKPKKMDSK CCCCCCCCCCCCCCC		-
710	Phosphorylation	LPHGDQQYLFSPSRE CCCCCCEEEECCCCC		27732954
713	Phosphorylation	GDQQYLFSPSREMPT CCCEEEECCCCCCCC		25159151
715	Phosphorylation	QQYLFSPSREMPTFS CEEEECCCCCCCCCC		29978859
781 (in isoform 3)	Phosphorylation	-		27251275
797	Phosphorylation	KKDPPQLTVQVLPSV CCCCCCCEEEECCCC		22199227
803	Phosphorylation	LTVQVLPSVDIDSIS CEEEECCCCCHHHCC		22199227
808	Phosphorylation	LPSVDIDSISNSSAD CCCCCHHHCCCCCCC		22199227
810	Phosphorylation	SVDIDSISNSSADVL CCCHHHCCCCCCCCC		22199227
812	Phosphorylation	DIDSISNSSADVLSP CHHHCCCCCCCCCCC		22199227
813	Phosphorylation	IDSISNSSADVLSPL HHHCCCCCCCCCCCC		22199227
818	Phosphorylation	NSSADVLSPLSSPKE CCCCCCCCCCCCCCC		22199227
821	Phosphorylation	ADVLSPLSSPKEASL CCCCCCCCCCCCCCC		22199227
822	Phosphorylation	DVLSPLSSPKEASLP CCCCCCCCCCCCCCC		30278072
827	Phosphorylation	LSSPKEASLPPVQTW CCCCCCCCCCCCCCE		19664994
874	Phosphorylation	KCDEIPDSEPILEFN CCCCCCCCCCHHCCC		29083192
1001	Phosphorylation	VNEALAETIAVMLGD HHHHHHHHHHHHHCC		28258704
1013	Ubiquitination	LGDREAKKQGPVATG HCCHHHHHHCCCCCC		21906983
1042	Phosphorylation	RVCTPLPTPQPTPPC EEECCCCCCCCCCCC		-
1046	Phosphorylation	PLPTPQPTPPCSPSS CCCCCCCCCCCCCCC		-
1050	Phosphorylation	PQPTPPCSPSSPAKE CCCCCCCCCCCCCCE		-
1063	Phosphorylation	KECVLVKTPDSSPCD CEEEEEECCCCCCCC		27732954
1066	Phosphorylation	VLVKTPDSSPCDSDH EEEECCCCCCCCCCC		25159151
1067	Phosphorylation	LVKTPDSSPCDSDHD EEECCCCCCCCCCCC		25159151
1071	Phosphorylation	PDSSPCDSDHDMAFP CCCCCCCCCCCCCCC		27732954
1099 (in isoform 3)	Phosphorylation	-		27642862
1129	Phosphorylation	SIDKLKVSSPELPKP EEEECCCCCCCCCCC		30266825
1130	Phosphorylation	IDKLKVSSPELPKPW EEECCCCCCCCCCCC		30266825
1151	Phosphorylation	LEEENPNSPQEELHP CCCCCCCCCCHHHCC		25849741
1260	Phosphorylation	YLTNLNDSLSSTLHD HHHCCCHHHHHHHHH		22468782
1262	Phosphorylation	TNLNDSLSSTLHDAV HCCCHHHHHHHHHHC		22468782
1296	Phosphorylation	FHADAILSFAKQNQE ECHHHHHHHHHHCHH		20068231
1304	Phosphorylation	FAKQNQESAVSQQAV HHHHCHHHHHHHHHH		22468782
1307	Phosphorylation	QNQESAVSQQAVYHS HCHHHHHHHHHHCCH		22468782
1312	Phosphorylation	AVSQQAVYHSEDLEN HHHHHHHCCHHHHHH		22468782
1314	Phosphorylation	SQQAVYHSEDLENSV HHHHHCCHHHHHHHH		22468782
1389	Phosphorylation	CASHGPMSLGELELE CHHCCCCCCCCEECC		23879269
1441	Ubiquitination	DVKQVEHKPSQSYLR CHHHCCCCCCHHHEE		-
1445	Phosphorylation	VEHKPSQSYLRVRNK CCCCCCHHHEEECCH		24719451
1452	Ubiquitination	SYLRVRNKSDIAPSQ HHEEECCHHHCCCCC		-
1453	Phosphorylation	YLRVRNKSDIAPSQQ HEEECCHHHCCCCCC		29978859
1458	Phosphorylation	NKSDIAPSQQQVSPG CHHHCCCCCCCCCCC		29978859
1501	Phosphorylation	QMPPAKMSVMLPSVN HCCCCCEEEEECCCC		-
1506	Phosphorylation	KMSVMLPSVNLEDCS CEEEEECCCCHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TALD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TALD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TALD3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TALD3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.