DNM3L_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DNM3L_MOUSE
• UniProt AC: Q9CWR8
• Protein Name: DNA (cytosine-5)-methyltransferase 3-like
• Gene Name: Dnmt3l
• Organism: Mus musculus (Mouse).
• Sequence Length: 421
• Subcellular Localization: Nucleus .
• Protein Description: Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context. [PubMed: 11719692]
• Protein Sequence: MGSRETPSSCSKTLETLDLETSDSSSPDADSPLEEQWLKSSPALKEDSVDVVLEDCKEPLSPSSPPTGREMIRYEVKVNRRSIEDICLCCGTLQVYTRHPLFEGGLCAPCKDKFLESLFLYDDDGHQSYCTICCSGGTLFICESPDCTRCYCFECVDILVGPGTSERINAMACWVCFLCLPFSRSGLLQRRKRWRHQLKAFHDQEGAGPMEIYKTVSAWKRQPVRVLSLFRNIDKVLKSLGFLESGSGSGGGTLKYVEDVTNVVRRDVEKWGPFDLVYGSTQPLGSSCDRCPGWYMFQFHRILQYALPRQESQRPFFWIFMDNLLLTEDDQETTTRFLQTEAVTLQDVRGRDYQNAMRVWSNIPGLKSKHAPLTPKEEEYLQAQVRSRSKLDAPKVDLLVKNCLLPLREYFKYFSQNSLPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MGSRETPSSCSKT --CCCCCCCCCCCCE	27.62	22006019
12	Ubiquitination	ETPSSCSKTLETLDL CCCCCCCCEEEEECC	62.55	-
13	Phosphorylation	TPSSCSKTLETLDLE CCCCCCCEEEEECCC	17.34	21149613
16	Phosphorylation	SCSKTLETLDLETSD CCCCEEEEECCCCCC	28.78	21149613
21	Phosphorylation	LETLDLETSDSSSPD EEEECCCCCCCCCCC	45.17	21149613
22	Phosphorylation	ETLDLETSDSSSPDA EEECCCCCCCCCCCC	26.56	21149613
24	Phosphorylation	LDLETSDSSSPDADS ECCCCCCCCCCCCCC	32.27	21149613
25	Phosphorylation	DLETSDSSSPDADSP CCCCCCCCCCCCCCC	51.37	21149613
26	Phosphorylation	LETSDSSSPDADSPL CCCCCCCCCCCCCCH	30.65	21149613
40	Phosphorylation	LEEQWLKSSPALKED HHHHHHHCCCCCCCC	39.11	22006019
41	Phosphorylation	EEQWLKSSPALKEDS HHHHHHCCCCCCCCC	16.77	22006019
45	Ubiquitination	LKSSPALKEDSVDVV HHCCCCCCCCCCCEE	62.68	-
48	Phosphorylation	SPALKEDSVDVVLED CCCCCCCCCCEEEEC	22.70	24759943
61	Phosphorylation	EDCKEPLSPSSPPTG ECCCCCCCCCCCCCC	33.19	21149613
63	Phosphorylation	CKEPLSPSSPPTGRE CCCCCCCCCCCCCHH	52.69	21149613
64	Phosphorylation	KEPLSPSSPPTGREM CCCCCCCCCCCCHHC	37.98	24759943
67	Phosphorylation	LSPSSPPTGREMIRY CCCCCCCCCHHCEEE	52.86	21149613
199	Ubiquitination	KRWRHQLKAFHDQEG HHHHHHHHHHHCCCC	42.30	-
239	Phosphorylation	NIDKVLKSLGFLESG CHHHHHHHCCCCCCC	29.57	22871156
245	Phosphorylation	KSLGFLESGSGSGGG HHCCCCCCCCCCCCC	40.17	22871156
247	Phosphorylation	LGFLESGSGSGGGTL CCCCCCCCCCCCCHH	38.78	22006019
255	Ubiquitination	GSGGGTLKYVEDVTN CCCCCHHEEEEECHH	47.27	-
261	Phosphorylation	LKYVEDVTNVVRRDV HEEEEECHHHHHHCH	34.32	22871156
270	Ubiquitination	VVRRDVEKWGPFDLV HHHHCHHHHCCCCEE	58.25	-
340	Phosphorylation	TTTRFLQTEAVTLQD HHHHHHHHEEEEHHH	28.23	-
376	Ubiquitination	KHAPLTPKEEEYLQA CCCCCCHHHHHHHHH	72.95	-
390	Ubiquitination	AQVRSRSKLDAPKVD HHHHCCCCCCCCHHH	49.64	-
395	Acetylation	RSKLDAPKVDLLVKN CCCCCCCHHHHHHHH	50.53	22902405
395	Ubiquitination	RSKLDAPKVDLLVKN CCCCCCCHHHHHHHH	50.53	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DNM3L_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DNM3L_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DNM3L_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNM3A_MOUSE	Dnmt3a	physical	16999741
EHMT2_MOUSE	Ehmt2	physical	18953337
DNM3B_MOUSE	Dnmt3b	physical	16543361

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.