DNM3B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DNM3B_MOUSE
• UniProt AC: O88509
• Protein Name: DNA (cytosine-5)-methyltransferase 3B
• Gene Name: Dnmt3b
• Organism: Mus musculus (Mouse).
• Sequence Length: 859
• Subcellular Localization: Nucleus . Accumulates in the major satellite repeats at pericentric heterochromatin.
• Protein Description: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Function as transcriptional corepressor by associating with ZHX1 (By similarity). Required for DUX4 silencing in somatic cells (By similarity)..
• Protein Sequence: MKGDSRHLNEEEGASGYEECIIVNGNFSDQSSDTKDAPSPPVLEAICTEPVCTPETRGRRSSSRLSKREVSSLLNYTQDMTGDGDRDDEVDDGNGSDILMPKLTRETKDTRTRSESPAVRTRHSNGTSSLERQRASPRITRGRQGRHHVQEYPVEFPATRSRRRRASSSASTPWSSPASVDFMEEVTPKSVSTPSVDLSQDGDQEGMDTTQVDAESRDGDSTEYQDDKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMPGMRWVQWFGDGKFSEISADKLVALGLFSQHFNLATFNKLVSYRKAMYHTLEKARVRAGKTFSSSPGESLEDQLKPMLEWAHGGFKPTGIEGLKPNKKQPVVNKSKVRRSDSRNLEPRRRENKSRRRTTNDSAASESPPPKRLKTNSYGGKDRGEDEESRERMASEVTNNKGNLEDRCLSCGKKNPVSFHPLFEGGLCQSCRDRFLELFYMYDEDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGAGTAEDAKLQEPWSCYMCLPQRCHGVLRRRKDWNMRLQDFFTTDPDLEEFEPPKLYPAIPAAKRRPIRVLSLFDGIATGYLVLKELGIKVEKYIASEVCAESIAVGTVKHEGQIKYVNDVRKITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYTRPKEGDNRPFFWMFENVVAMKVNDKKDISRFLACNPVMIDAIKVSAAHRARYFWGNLPGMNRPVMASKNDKLELQDCLEFSRTAKLKKVQTITTKSNSIRQGKNQLFPVVMNGKDDVLWCTELERIFGFPAHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	SDTKDAPSPPVLEAI CCCCCCCCCCCCEEC	43.48	25159016
48	Phosphorylation	PVLEAICTEPVCTPE CCCEECCCCCCCCCC	36.89	25293948
53	Phosphorylation	ICTEPVCTPETRGRR CCCCCCCCCCCCCCC	25.13	25159016
57	Methylation	PVCTPETRGRRSSSR CCCCCCCCCCCCCCC	34.65	-
61	Phosphorylation	PETRGRRSSSRLSKR CCCCCCCCCCCCCHH	31.16	17622165
62	Phosphorylation	ETRGRRSSSRLSKRE CCCCCCCCCCCCHHH	20.05	17622165
63	Phosphorylation	TRGRRSSSRLSKREV CCCCCCCCCCCHHHH	38.19	-
77	Phosphorylation	VSSLLNYTQDMTGDG HHHHHHHCCCCCCCC	19.61	25890499
81	Phosphorylation	LNYTQDMTGDGDRDD HHHCCCCCCCCCCCC	40.17	25890499
96	Phosphorylation	EVDDGNGSDILMPKL CCCCCCCCCCCHHHC	26.02	22006019
112	Phosphorylation	RETKDTRTRSESPAV CCCCCCCCCCCCCCC	40.41	25266776
114	Phosphorylation	TKDTRTRSESPAVRT CCCCCCCCCCCCCEE	41.64	25266776
116	Phosphorylation	DTRTRSESPAVRTRH CCCCCCCCCCCEECC	21.29	25266776
124	Phosphorylation	PAVRTRHSNGTSSLE CCCEECCCCCCCHHH	33.39	-
128	Phosphorylation	TRHSNGTSSLERQRA ECCCCCCCHHHHHHC	34.03	-
140	Phosphorylation	QRASPRITRGRQGRH HHCCCCCCCCCCCCC	28.49	28059163
152	Phosphorylation	GRHHVQEYPVEFPAT CCCCCCCCCCCCCCC	8.76	-
167	Phosphorylation	RSRRRRASSSASTPW HHHHHCCCCCCCCCC	24.02	25159016
168	Phosphorylation	SRRRRASSSASTPWS HHHHCCCCCCCCCCC	29.01	25159016
169	Phosphorylation	RRRRASSSASTPWSS HHHCCCCCCCCCCCC	24.60	25159016
171	Phosphorylation	RRASSSASTPWSSPA HCCCCCCCCCCCCCC	36.63	25159016
172	Phosphorylation	RASSSASTPWSSPAS CCCCCCCCCCCCCCC	28.61	25159016
175	Phosphorylation	SSASTPWSSPASVDF CCCCCCCCCCCCCCC	27.87	25159016
176	Phosphorylation	SASTPWSSPASVDFM CCCCCCCCCCCCCCH	22.18	25293948
179	Phosphorylation	TPWSSPASVDFMEEV CCCCCCCCCCCHHHC	26.13	25159016
187	Phosphorylation	VDFMEEVTPKSVSTP CCCHHHCCCCCCCCC	28.42	25367039
190	Phosphorylation	MEEVTPKSVSTPSVD HHHCCCCCCCCCCCC	23.62	25367039
192	Phosphorylation	EVTPKSVSTPSVDLS HCCCCCCCCCCCCCC	41.51	22006019
193	Phosphorylation	VTPKSVSTPSVDLSQ CCCCCCCCCCCCCCC	19.89	25367039
195	Phosphorylation	PKSVSTPSVDLSQDG CCCCCCCCCCCCCCC	28.49	25367039
199	Phosphorylation	STPSVDLSQDGDQEG CCCCCCCCCCCCCCC	23.05	25367039
209	Phosphorylation	GDQEGMDTTQVDAES CCCCCCCCCEEECCC	15.38	25367039
210	Phosphorylation	DQEGMDTTQVDAESR CCCCCCCCEEECCCC	23.49	25367039
216	Phosphorylation	TTQVDAESRDGDSTE CCEEECCCCCCCCCC	37.07	25367039
367	Phosphorylation	KQPVVNKSKVRRSDS CCCCCCHHHCCCCCC	31.05	21454597
394	Phosphorylation	RRRTTNDSAASESPP CCCCCCCCCCCCCCC	28.01	25159016
397	Phosphorylation	TTNDSAASESPPPKR CCCCCCCCCCCCCCC	38.02	25159016
399	Phosphorylation	NDSAASESPPPKRLK CCCCCCCCCCCCCCC	39.96	25159016
415	Citrullination	NSYGGKDRGEDEESR CCCCCCCCCCCHHHH	54.62	-
415	Citrullination	NSYGGKDRGEDEESR CCCCCCCCCCCHHHH	54.62	24463520
421	Phosphorylation	DRGEDEESRERMASE CCCCCHHHHHHHHHH	37.08	20139300
841	Phosphorylation	KLLGRSWSVPVIRHL HHHCCCCCHHHHHHH	20.14	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DNM3B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DNM3B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DNM3B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
E2F6_MOUSE	E2f6	physical	20439742
NR6A1_MOUSE	Nr6a1	physical	16631596
CBX2_MOUSE	Cbx2	physical	17726103
BMI1_MOUSE	Bmi1	physical	17726103
PCGF2_MOUSE	Pcgf2	physical	17726103
EHMT2_MOUSE	Ehmt2	physical	18953337
DNM3A_MOUSE	Dnmt3a	physical	17938196
DNM3L_MOUSE	Dnmt3l	physical	17938196

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.