dbPTM

DNM3A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DNM3A_MOUSE
UniProt AC	O88508
Protein Name	DNA (cytosine-5)-methyltransferase 3A
Gene Name	Dnmt3a
Organism	Mus musculus (Mouse).
Sequence Length	908
Subcellular Localization	Nucleus . Cytoplasm. Accumulates in the major satellite repeats at pericentric heterochromatin.
Protein Description	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity..
Protein Sequence	MPSSGPGDTSSSSLEREDDRKEGEEQEENRGKEERQEPSATARKVGRPGRKRKHPPVESSDTPKDPAVTTKSQPMAQDSGPSDLLPNGDLEKRSEPQPEEGSPAAGQKGGAPAEGEGTETPPEASRAVENGCCVTKEGRGASAGEGKEQKQTNIESMKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAVMNAVEENQASGESQKVEEASPPAVQQPTDPASPTVATTPEPVGGDAGDKNATKAADDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPACHDSDESDSGKAVEVQNKQMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTTEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFIGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPSSGPGDTS -----CCCCCCCCCC	46.78	27841257
4	Phosphorylation	----MPSSGPGDTSS ----CCCCCCCCCCC	43.04	25159016
9	Phosphorylation	PSSGPGDTSSSSLER CCCCCCCCCCCCCCC	36.10	28066266
10	Phosphorylation	SSGPGDTSSSSLERE CCCCCCCCCCCCCCH	32.72	28066266
11	Phosphorylation	SGPGDTSSSSLERED CCCCCCCCCCCCCHH	26.49	28066266
12	Phosphorylation	GPGDTSSSSLEREDD CCCCCCCCCCCCHHH	38.41	28066266
13	Phosphorylation	PGDTSSSSLEREDDR CCCCCCCCCCCHHHH	35.88	25159016
62	Phosphorylation	PPVESSDTPKDPAVT CCCCCCCCCCCCCCC	33.90	27841257
79	Phosphorylation	SQPMAQDSGPSDLLP CCCCCCCCCCCCCCC	40.29	30635358
82	Phosphorylation	MAQDSGPSDLLPNGD CCCCCCCCCCCCCCC	44.40	30635358
94	Phosphorylation	NGDLEKRSEPQPEEG CCCHHHCCCCCCCCC	65.77	25619855
102	Phosphorylation	EPQPEEGSPAAGQKG CCCCCCCCCCCCCCC	18.04	25521595
118	Phosphorylation	APAEGEGTETPPEAS CCCCCCCCCCCHHHH	32.17	25619855
120	Phosphorylation	AEGEGTETPPEASRA CCCCCCCCCHHHHHH	43.94	22942356
125	Phosphorylation	TETPPEASRAVENGC CCCCHHHHHHHHHCC	21.07	28066266
167	Methylation	EGSRGRLRGGLGWES ECCCCCCCCCCCCCH	35.45	24129315
174	Phosphorylation	RGGLGWESSLRQRPM CCCCCCCHHHCCCCC	28.32	28066266
175	Phosphorylation	GGLGWESSLRQRPMP CCCCCCHHHCCCCCC	18.96	28066266
185	Phosphorylation	QRPMPRLTFQAGDPY CCCCCEEEEECCCCE	18.25	-
196	Ubiquitination	GDPYYISKRKRDEWL CCCEEECCCCHHHHH	52.99	22790023
229	Phosphorylation	AVEENQASGESQKVE HHHHHHCCCCCCCCH	33.07	26824392
239	Phosphorylation	SQKVEEASPPAVQQP CCCCHHCCCCCCCCC	34.39	21149613
247	Phosphorylation	PPAVQQPTDPASPTV CCCCCCCCCCCCCCC	50.72	21149613
251	Phosphorylation	QQPTDPASPTVATTP CCCCCCCCCCCCCCC	26.88	25521595
253	Phosphorylation	PTDPASPTVATTPEP CCCCCCCCCCCCCCC	21.93	25521595
256	Phosphorylation	PASPTVATTPEPVGG CCCCCCCCCCCCCCC	38.25	21149613
257	Phosphorylation	ASPTVATTPEPVGGD CCCCCCCCCCCCCCC	18.86	25521595
344	Phosphorylation	VEKLMPLSSFCSAFH EEECCCHHHHHHHHH	18.59	28059163
345	Phosphorylation	EKLMPLSSFCSAFHQ EECCCHHHHHHHHHH	37.65	28059163
386	Phosphorylation	LFPACHDSDESDSGK CCCCCCCCCCCCCCC	21.44	21149613
389	Phosphorylation	ACHDSDESDSGKAVE CCCCCCCCCCCCEEE	41.91	15456878
391	Phosphorylation	HDSDESDSGKAVEVQ CCCCCCCCCCEEEEC	52.01	30635358
676	Acetylation	GMVRHQGKIMYVGDV EEEEECCEEEEECCC	20.10	22826441
835	Phosphorylation	TITTRSNSIKQGKDQ EEECCCCCHHCCCCC	32.20	27600695
890	Phosphorylation	RLLGRSWSVPVIRHL HHHCCCCHHHHHHHH	20.14	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
386	S	Phosphorylation	Kinase	CK2A1	P68400	PSP
389	S	Phosphorylation	Kinase	CK2A1	P68400	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DNM3A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DNM3A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNM3L_MOUSE	Dnmt3l	physical	20211142
SMCA4_HUMAN	SMARCA4	physical	16322236
NR6A1_MOUSE	Nr6a1	physical	16631596
EHMT2_MOUSE	Ehmt2	physical	18953337
TEBP_MOUSE	Ptges3	physical	8772199
H2B11_XENLA	hist1h2bj	physical	16026162
H4_XENLA	hist1h4a	physical	16026162
H2A1_XENLA	h2afx	physical	16026162
H32_XENLA	hist2h3c	physical	16026162

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DNM3A_MOUSE

Related Literatures of Post-Translational Modification