H2B11_XENLA - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H2B11_XENLA
• UniProt AC: P02281
• Protein Name: Histone H2B 1.1
• Organism: Xenopus laevis (African clawed frog).
• Sequence Length: 126
• Subcellular Localization: Nucleus. Chromosome.
• Protein Description: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling..
• Protein Sequence: MPEPAKSAPAPKKGSKKAVTKTQKKDGKKRRKSRKESYAIYVYKVLKQVHPDTGISSKAMSIMNSFVNDVFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MPEPAKSAPAPKK --CCCCCCCCCCCCC	58.84	-
13	Acetylation	KSAPAPKKGSKKAVT CCCCCCCCCCCCCCC	68.32	-
15	Phosphorylation	APAPKKGSKKAVTKT CCCCCCCCCCCCCHH	39.60	12757711
16	Acetylation	PAPKKGSKKAVTKTQ CCCCCCCCCCCCHHC	54.11	-
21	Acetylation	GSKKAVTKTQKKDGK CCCCCCCHHCCCCCC	42.22	-
113	O-linked_Glycosylation	ELAKHAVSEGTKAVT HHHHHHHHHHCHHHH	30.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of H2B11_XENLA !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of H2B11_XENLA !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H2B11_XENLA !!

Protein-Protein Interaction

Oops, there are no PPI records of H2B11_XENLA !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Apoptotic phosphorylation of histone H2B is mediated by mammaliansterile twenty kinase.";
Cheung W.L., Ajiro K., Samejima K., Kloc M., Cheung P., Mizzen C.A.,Beeser A., Etkin L.D., Chernoff J., Earnshaw W.C., Allis C.D.;
Cell 113:507-517(2003).
Cited for: PHOSPHORYLATION AT SER-15.
PubMed: 12757711