SYDC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYDC_MOUSE
• UniProt AC: Q922B2
• Protein Name: Aspartate--tRNA ligase, cytoplasmic
• Gene Name: Dars
• Organism: Mus musculus (Mouse).
• Sequence Length: 501
• Subcellular Localization: Cytoplasm.
• Protein Description: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA..
• Protein Sequence: MPSTNASRKGQEKPREIVDAAEDYAKERYGISSMIQSQEKPDRVLVRVKDLTVQKADDVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIIDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAIRPEVEGEEDGRATVNQDTRLDNRVIDLRTSTSQAIFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVEEIADTLVQIFKGLQERFQTEIQTVSKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMDDEEDLSTPNEKLLGRLVKEKYDTDFYVLDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPSTNASRKG -----CCCCCCCCCC	32.75	25168779
4	Phosphorylation	----MPSTNASRKGQ ----CCCCCCCCCCC	29.00	25168779
7	Phosphorylation	-MPSTNASRKGQEKP -CCCCCCCCCCCCCC	36.27	18846507
13	Ubiquitination	ASRKGQEKPREIVDA CCCCCCCCCHHHHHH	41.30	-
26	Ubiquitination	DAAEDYAKERYGISS HHHHHHHHHHHCHHH	36.17	-
32	Phosphorylation	AKERYGISSMIQSQE HHHHHCHHHHHCCCC	14.97	28464351
49	Ubiquitination	DRVLVRVKDLTVQKA CCEEEEEEECEEEEC	36.13	-
52	Phosphorylation	LVRVKDLTVQKADDV EEEEEECEEEECCCE	30.90	-
74	Acetylation	HTSRAKGKQCFLVLR EECCCCCCEEEEEEE	43.09	-
74	Ubiquitination	HTSRAKGKQCFLVLR EECCCCCCEEEEEEE	43.09	-
74	Malonylation	HTSRAKGKQCFLVLR EECCCCCCEEEEEEE	43.09	26320211
76	S-palmitoylation	SRAKGKQCFLVLRQQ CCCCCCEEEEEEECC	3.03	28526873
98	Phosphorylation	VAVGDHASKQMVKFA EEECCHHHHHHHHHH	21.72	28059163
99	Ubiquitination	AVGDHASKQMVKFAA EECCHHHHHHHHHHH	43.10	-
103	Malonylation	HASKQMVKFAANINK HHHHHHHHHHHCCCH	24.76	26320211
103	Ubiquitination	HASKQMVKFAANINK HHHHHHHHHHHCCCH	24.76	-
103	Acetylation	HASKQMVKFAANINK HHHHHHHHHHHCCCH	24.76	23236377
110	Ubiquitination	KFAANINKESIIDVE HHHHCCCHHHCCCHH	49.38	-
130	S-nitrosylation	VNQKIGSCTQQDVEL HHHHHCCCCHHHHHH	3.16	21278135
130	Glutathionylation	VNQKIGSCTQQDVEL HHHHHCCCCHHHHHH	3.16	24333276
130	S-nitrosocysteine	VNQKIGSCTQQDVEL HHHHHCCCCHHHHHH	3.16	-
143	Phosphorylation	ELHVQKIYVISLAEP HHEEEEEEEEECCCC	9.96	25195567
189	Phosphorylation	NRVIDLRTSTSQAIF CEEEEECCCHHHHHH	43.59	29472430
190	Phosphorylation	RVIDLRTSTSQAIFR EEEEECCCHHHHHHH	21.45	29472430
191	Phosphorylation	VIDLRTSTSQAIFRL EEEECCCHHHHHHHH	25.01	29472430
192	Phosphorylation	IDLRTSTSQAIFRLQ EEECCCHHHHHHHHH	19.85	29472430
203	S-palmitoylation	FRLQSGICHLFRETL HHHHHHHHHHHHHHH	2.32	28526873
236	Phosphorylation	EGGANVFTVSYFKNN CCCCCEEEEEEECCC	12.31	24759943
241	Ubiquitination	VFTVSYFKNNAYLAQ EEEEEEECCCEEECC	40.85	-
245	Phosphorylation	SYFKNNAYLAQSPQL EEECCCEEECCCHHH	12.51	-
249	Phosphorylation	NNAYLAQSPQLYKQM CCEEECCCHHHHHHH	14.70	25521595
253	Phosphorylation	LAQSPQLYKQMCICA ECCCHHHHHHHHHHC	8.23	25293948
267	S-palmitoylation	ADFEKVFCIGPVFRA CCCCEEEEEECEEEC	3.83	28526873
267	S-nitrosylation	ADFEKVFCIGPVFRA CCCCEEEEEECEEEC	3.83	21278135
267	S-nitrosocysteine	ADFEKVFCIGPVFRA CCCCEEEEEECEEEC	3.83	-
323	Phosphorylation	GLQERFQTEIQTVSK HHHHHHHHHHHHHHC	32.13	28464351
330	Ubiquitination	TEIQTVSKQFPCEPF HHHHHHHCCCCCCCC	52.18	-
348	Phosphorylation	EPTLRLEYCEALAML CCCHHHHHHHHHHHH	10.53	-
349	Glutathionylation	PTLRLEYCEALAMLR CCHHHHHHHHHHHHH	1.48	24333276
349	S-palmitoylation	PTLRLEYCEALAMLR CCHHHHHHHHHHHHH	1.48	28526873
374	Acetylation	DLSTPNEKLLGRLVK CCCCCCHHHHHHHHH	56.50	-
383	Ubiquitination	LGRLVKEKYDTDFYV HHHHHHHHHCCCEEE	42.58	-
383	Succinylation	LGRLVKEKYDTDFYV HHHHHHHHHCCCEEE	42.58	23954790
411	Ubiquitination	MPDPRNPKQSNSYDM CCCCCCCCCCCCCCC	70.66	-
451	Acetylation	HHGIDLEKIKAYIDS HCCCCHHHHHHHHHH	57.72	22826441
451	Ubiquitination	HHGIDLEKIKAYIDS HCCCCHHHHHHHHHH	57.72	-
500	Phosphorylation	PRDPKRLTP------ CCCCCCCCC------	30.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYDC_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYDC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYDC_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SYDC_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.