dbPTM

I20L2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	I20L2_MOUSE
UniProt AC	Q3U1G5
Protein Name	Interferon-stimulated 20 kDa exonuclease-like 2
Gene Name	Isg20l2
Organism	Mus musculus (Mouse).
Sequence Length	368
Subcellular Localization	Nucleus, nucleolus.
Protein Description	3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group..
Protein Sequence	MSTILLNLDFGQPSKKAFGGNAKHQRFVKKRRFLEQKGFLNKKNQPPNKVSKLNSEPPKKGETSRVDGILKILPCPKKKEAAASKRDSERSKDKKAPLSWLTPAPSKKTASVVSKIDLLGEFQSALPKTKSTQKKGSKKKSLKKKIATENSTQAQSKDKGSKKKPLKKNAVPNSTQARSEDKCPTVPQNLPGKMVAIDCEMVGTGPKGRVSSLARCSIVNYNGDVLYDEYVLPPCYIVNYRTRWSGIRKCHMVNATPFKTARSQILKILSGKVVIGHAIHNDYKALQYFHPKSLTRDTSRIPLLNRKADCPENVTLSLKHLTKKLLSRDIQVGNTGHSSVEDAQATMELYKLVEVEWEQHLAQNPPEN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Acetylation	KAFGGNAKHQRFVKK CCCCCCHHHHHHHHH	44.25	23806337
99	Phosphorylation	KDKKAPLSWLTPAPS CCCCCCCHHHCCCCC	20.98	21454597
102	Phosphorylation	KAPLSWLTPAPSKKT CCCCHHHCCCCCCCC	15.90	21454597
114	Phosphorylation	KKTASVVSKIDLLGE CCCHHHHHHHHHHHH	23.03	21454597
209	Methylation	VGTGPKGRVSSLARC ECCCCCCCCHHHCCC	31.13	16186133
351	Acetylation	QATMELYKLVEVEWE HHHHHHHHHHHHHHH	59.69	19860113

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of I20L2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of I20L2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of I20L2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of I20L2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of I20L2_MOUSE

Related Literatures of Post-Translational Modification