2A5G_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 2A5G_MOUSE
• UniProt AC: Q60996
• Protein Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
• Gene Name: Ppp2r5c
• Organism: Mus musculus (Mouse).
• Sequence Length: 524
• Subcellular Localization: Nucleus. Chromosome, centromere.
• Protein Description: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation (By similarity)..
• Protein Sequence: MLTCNKAGSGMVVDAASSNGPFQPVALLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEAVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQYAVYSQASAVSIPVAMETDGPQFEDVQMLKKTVSDEARQAQKELKKDRPLVRRKSELPQDPHTEKALEAHCRASELLSQDGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLTCNKAG -------CCCCCCCC	6.71	-
64	Ubiquitination	SDPLSDLKWKEVKRA CCCHHHCCHHHHHHH	62.30	-
192	Acetylation	TLHRIYGKFLGLRAY HHHHHHHHHHCHHHH	22.05	22826441
279	Phosphorylation	VQFLEKDSTLTEPVV HHHHHCCCCCCHHHH	36.06	-
333	Ubiquitination	PLFRQLAKCVSSPHF HHHHHHHHHHCCCCH	43.70	-
354	Phosphorylation	LYYWNNEYIMSLISD HHHCCCHHHHHHHCC	12.21	-
357	Phosphorylation	WNNEYIMSLISDNAA CCCHHHHHHHCCCHH	17.00	-
360	Phosphorylation	EYIMSLISDNAAKIL HHHHHHHCCCHHHHH	30.06	-
373	Phosphorylation	ILPIMFPSLYRNSKT HHHHCCHHHHHCCCC	27.11	28285833
375	Phosphorylation	PIMFPSLYRNSKTHW HHCCHHHHHCCCCHH	16.46	28285833
385	Phosphorylation	SKTHWNKTIHGLIYN CCCHHHHHHHHHHHH	18.26	25521595
497	Phosphorylation	RPLVRRKSELPQDPH CCCCCCHHCCCCCCH	42.42	26824392
520	Phosphorylation	CRASELLSQDGR--- HHHHHHHCCCCC---	38.56	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 2A5G_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 2A5G_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 2A5G_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
2AAA_HUMAN	PPP2R1A	physical	26496610
2AAB_HUMAN	PPP2R1B	physical	26496610
U2AF2_HUMAN	U2AF2	physical	26496610
ADNP2_HUMAN	ADNP2	physical	26496610
ELL2_HUMAN	ELL2	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-497, AND MASSSPECTROMETRY.
PubMed: 19367708