LYPA1_MOUSE - dbPTM
LYPA1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LYPA1_MOUSE
UniProt AC P97823
Protein Name Acyl-protein thioesterase 1
Gene Name Lypla1
Organism Mus musculus (Mouse).
Sequence Length 230
Subcellular Localization Cytoplasm.
Protein Description Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity (By similarity)..
Protein Sequence MCGNNMSAPMPAVVPAARKATAAVIFLHGLGDTGHGWAEAFAGIKSPHIKYICPHAPVMPVTLNMNMAMPSWFDIVGLSPDSQEDESGIKQAAETVKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFSQGPINSANRDISVLQCHGDCDPLVPLMFGSLTVERLKALINPANVTFKIYEGMMHSSCQQEMMDVKHFIDKLLPPID
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2S-palmitoylation------MCGNNMSAP
------CCCCCCCCC		8.8623396970
47UbiquitinationAFAGIKSPHIKYICP
HHCCCCCCCCEEECC		28.3727667366
97AcetylationKQAAETVKALIDQEV
HHHHHHHHHHHHHHH		44.9123201123
105AcetylationALIDQEVKNGIPSNR
HHHHHHHHCCCCCCC		49.0223954790
105UbiquitinationALIDQEVKNGIPSNR
HHHHHHHHCCCCCCC		49.0222790023
144S-palmitoylationAGVTALSCWLPLRAS
CCCHHHHHCCCHHCH		4.5028526873
144S-nitrosylationAGVTALSCWLPLRAS
CCCHHHHHCCCHHCH		4.5021278135
144S-nitrosocysteineAGVTALSCWLPLRAS
CCCHHHHHCCCHHCH		4.50-
151PhosphorylationCWLPLRASFSQGPIN
HCCCHHCHHCCCCCC		20.9928066266
153PhosphorylationLPLRASFSQGPINSA
CCHHCHHCCCCCCCC		31.5628066266
165UbiquitinationNSANRDISVLQCHGD
CCCCCCEEEEEECCC		22.5127667366
166UbiquitinationSANRDISVLQCHGDC
CCCCCEEEEEECCCC		4.3527667366
190MalonylationSLTVERLKALINPAN
CEEHHHHHHHHCHHC		47.5726320211
190UbiquitinationSLTVERLKALINPAN
CEEHHHHHHHHCHHC		47.57-
190AcetylationSLTVERLKALINPAN
CEEHHHHHHHHCHHC		47.5723806337
211S-nitrosocysteineEGMMHSSCQQEMMDV
CCCCCHHHHHHHHHH		5.62-
211S-nitrosylationEGMMHSSCQQEMMDV
CCCCCHHHHHHHHHH		5.6221278135
224AcetylationDVKHFIDKLLPPID-
HHHHHHHHHCCCCC-		47.2923576753
224UbiquitinationDVKHFIDKLLPPID-
HHHHHHHHHCCCCC-		47.2927667366
224MalonylationDVKHFIDKLLPPID-
HHHHHHHHHCCCCC-		47.2926073543
250Ubiquitination---------------------------
---------------------------		27667366
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LYPA1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LYPA1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LYPA1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LYPA1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LYPA1_MOUSE

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Related Literatures of Post-Translational Modification

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