PNO1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PNO1_MOUSE
• UniProt AC: Q9CPS7
• Protein Name: RNA-binding protein PNO1
• Gene Name: Pno1
• Organism: Mus musculus (Mouse).
• Sequence Length: 248
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA..
• Protein Sequence: METQSTGTEDGFTPVTHRGGRRAKKRQAEQSSAAGQDGEAGRMDTEEARPAKRPVFPPLSGDQLLTGKEETRKIPVPGNRYTPLKENWMKIFTPIVEHLGLQIRFNLKSRNVEIRTCKDTKDVSALTKAADFVKAFVLGFQVEDALALIRLDDLFLESFEITDVKPLKGDHLSRAIGRIAGKGGKTKFTIENVTRTRIVLADVHVHILGSFQNIKMARTAICNLILGNPPSKVYGNIRAVASRSADRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----METQSTGTED -----CCCCCCCCCC	26.90	25619855
5	Phosphorylation	---METQSTGTEDGF ---CCCCCCCCCCCC	35.90	25619855
6	Phosphorylation	--METQSTGTEDGFT --CCCCCCCCCCCCC	38.00	25619855
8	Phosphorylation	METQSTGTEDGFTPV CCCCCCCCCCCCCCC	30.87	25619855
13	Phosphorylation	TGTEDGFTPVTHRGG CCCCCCCCCCCCCCC	23.52	25619855
16	Phosphorylation	EDGFTPVTHRGGRRA CCCCCCCCCCCCHHH	13.68	28066266
244	Phosphorylation	IRAVASRSADRF--- HHHHHCCCCCCC---	31.84	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PNO1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PNO1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PNO1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PNO1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.