HEAT3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEAT3_MOUSE
• UniProt AC: Q8BQM4
• Protein Name: HEAT repeat-containing protein 3
• Gene Name: Heatr3
• Organism: Mus musculus (Mouse).
• Sequence Length: 679
• Protein Sequence: MGKSRTKRFKRPQFSPIESCQAEAAAASNGTGDEEDDGPAAELLEKLQHPSAEVRECACAGLARLVQQRPALPDLARRDAVRRLGPLLLDSSLAVRETAAGALRNLSACGGFDVCDDMVAKDIMTPLVALLRECLSGLDSNEMSPQEKADKRNPVESIANEAVNVLWNVCECSGRAVSIFNKEGCLEIVLQYLRRFPTSIDLAVSVAYCLQTVTEDNPELLKSFDGTALRVLESALLCPVASMEYILLKTLVAGTIWNLKDIIPSKSQAEIINAILGALSEVLGMNTGNMVIQMKEAETQRLKTAAESEDILANANGDDLVEDDEMEEIPHKRKLRRKTFISDLLPPTDKELREAMALLTAQQTALEVIVNMCCSEDPSDDEWEELSSSDESEAFMENSFSECSGHLMSPLCLSHEIHSALTNCLIPEKVFEKTSSPNSVAVDICSKNPTWKPLIRKMNTIQCRALMCLQSLVSLLDIDHLGGAPALQTLAQHLSQILFSQPDFAKHDDFLEAISSALRALLQTMASKNIPQCMTPEQLMTLCREGIHSSSIGVRVNVVSILGITGSVLAKDDGTLDTLKTIGCFLLEVATKDPSLVVTGEALDALFDVFADGEAAEKASVQIKLLAALKEFQPVFKMKIRKEGRGKYSPDQLCVLDNVKMNLRRFIAYQETVEKRLTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	RFKRPQFSPIESCQA CCCCCCCCCCHHHHH	21.52	25521595
19	Phosphorylation	PQFSPIESCQAEAAA CCCCCCHHHHHHHHH	16.55	25619855
28	Phosphorylation	QAEAAAASNGTGDEE HHHHHHHHCCCCCCC	30.94	26824392
31	Phosphorylation	AAAASNGTGDEEDDG HHHHHCCCCCCCCCC	45.79	27087446
136	Phosphorylation	ALLRECLSGLDSNEM HHHHHHHCCCCCCCC	49.31	25159016
140	Phosphorylation	ECLSGLDSNEMSPQE HHHCCCCCCCCCHHH	39.47	25159016
144	Phosphorylation	GLDSNEMSPQEKADK CCCCCCCCHHHHHHC	19.77	25521595
178	Phosphorylation	ECSGRAVSIFNKEGC HCCCCEEEECCCCCH	22.07	25338131
222	Ubiquitination	EDNPELLKSFDGTAL CCCHHHHHHCCHHHH	62.80	-
308	Phosphorylation	RLKTAAESEDILANA HHHHHHHHHHHHHHC	35.52	25338131
339	Phosphorylation	KRKLRRKTFISDLLP HHHHCCCHHHHHCCC	25.12	26824392
342	Phosphorylation	LRRKTFISDLLPPTD HCCCHHHHHCCCCCC	20.29	27600695
647	Acetylation	IRKEGRGKYSPDQLC ECCCCCCCCCHHHEE	40.99	22826441
648	Phosphorylation	RKEGRGKYSPDQLCV CCCCCCCCCHHHEEE	28.41	25293948
649	Phosphorylation	KEGRGKYSPDQLCVL CCCCCCCCHHHEEEE	26.03	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEAT3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEAT3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEAT3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HEAT3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.