U3IP2_MOUSE - dbPTM
U3IP2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID U3IP2_MOUSE
UniProt AC Q91WM3
Protein Name U3 small nucleolar RNA-interacting protein 2
Gene Name Rrp9
Organism Mus musculus (Mouse).
Sequence Length 475
Subcellular Localization Nucleus, nucleolus.
Protein Description Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA..
Protein Sequence MSTAVATRKRAKPAPGPGAAPVAGKRRRKVDSAADRGKSKGGGKMNEEISSDSESESLAPRKTEEEEEEELEETAQEKKLRLAKLYLEQLRQQEEEKAEARAFEEDQVAGRLKEDVLEQRGRLQKSVAKEIQAPAPTDIRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHVIPRAKKGAQGQPAGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRKGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLHGEPGLEQPFWVSSVAALLNTDLVATGSHNARVRLWQCGEGFRQLDPLCDIPLVGFINSLKFSSAGDFLVAGVGQEHRLGRWWRIKEARNSVCIIPLRRLPVSPVAGS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
10MethylationTAVATRKRAKPAPGP
CHHHCCCCCCCCCCC
44.55-
12AcetylationVATRKRAKPAPGPGA
HHCCCCCCCCCCCCC
45.83-
25AcetylationGAAPVAGKRRRKVDS
CCCCCCCCCCCCCCC
32.7588787
26DimethylationAAPVAGKRRRKVDSA
CCCCCCCCCCCCCCH
42.59-
26MethylationAAPVAGKRRRKVDSA
CCCCCCCCCCCCCCH
42.5918963549
27DimethylationAPVAGKRRRKVDSAA
CCCCCCCCCCCCCHH
46.38-
27MethylationAPVAGKRRRKVDSAA
CCCCCCCCCCCCCHH
46.3818963559
50PhosphorylationGKMNEEISSDSESES
CCCCCCCCCCCCCCC
31.2227087446
51PhosphorylationKMNEEISSDSESESL
CCCCCCCCCCCCCCC
51.3127087446
53PhosphorylationNEEISSDSESESLAP
CCCCCCCCCCCCCCC
44.9927087446
55PhosphorylationEISSDSESESLAPRK
CCCCCCCCCCCCCCC
36.1225168779
57PhosphorylationSSDSESESLAPRKTE
CCCCCCCCCCCCCCH
38.8325168779
63PhosphorylationESLAPRKTEEEEEEE
CCCCCCCCHHHHHHH
50.3226370283
84AcetylationEKKLRLAKLYLEQLR
HHHHHHHHHHHHHHH
42.1123806337
169PhosphorylationFSAAKDCTIIKWSVE
HHHCCCCEEEEEECC
35.5518779572
266AcetylationTSHDRSVKVWNAAEN
CCCCCCEEEEEHHHC
42.667712905
470PhosphorylationPLRRLPVSPVAGS--
ECCCCCCCCCCCC--
16.2427087446
475PhosphorylationPVSPVAGS-------
CCCCCCCC-------
27.5825619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of U3IP2_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
12KAcetylation

-
25KAcetylation

-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of U3IP2_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of U3IP2_MOUSE !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of U3IP2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-470, AND MASSSPECTROMETRY.
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50; SER-51 AND SER-470,AND MASS SPECTROMETRY.
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50 AND SER-51, AND MASSSPECTROMETRY.

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