UniProt ID | U3IP2_MOUSE | |
---|---|---|
UniProt AC | Q91WM3 | |
Protein Name | U3 small nucleolar RNA-interacting protein 2 | |
Gene Name | Rrp9 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 475 | |
Subcellular Localization | Nucleus, nucleolus. | |
Protein Description | Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA.. | |
Protein Sequence | MSTAVATRKRAKPAPGPGAAPVAGKRRRKVDSAADRGKSKGGGKMNEEISSDSESESLAPRKTEEEEEEELEETAQEKKLRLAKLYLEQLRQQEEEKAEARAFEEDQVAGRLKEDVLEQRGRLQKSVAKEIQAPAPTDIRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHVIPRAKKGAQGQPAGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRKGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLHGEPGLEQPFWVSSVAALLNTDLVATGSHNARVRLWQCGEGFRQLDPLCDIPLVGFINSLKFSSAGDFLVAGVGQEHRLGRWWRIKEARNSVCIIPLRRLPVSPVAGS | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
10 | Methylation | TAVATRKRAKPAPGP CHHHCCCCCCCCCCC | 44.55 | - | |
12 | Acetylation | VATRKRAKPAPGPGA HHCCCCCCCCCCCCC | 45.83 | - | |
25 | Acetylation | GAAPVAGKRRRKVDS CCCCCCCCCCCCCCC | 32.75 | 88787 | |
26 | Dimethylation | AAPVAGKRRRKVDSA CCCCCCCCCCCCCCH | 42.59 | - | |
26 | Methylation | AAPVAGKRRRKVDSA CCCCCCCCCCCCCCH | 42.59 | 18963549 | |
27 | Dimethylation | APVAGKRRRKVDSAA CCCCCCCCCCCCCHH | 46.38 | - | |
27 | Methylation | APVAGKRRRKVDSAA CCCCCCCCCCCCCHH | 46.38 | 18963559 | |
50 | Phosphorylation | GKMNEEISSDSESES CCCCCCCCCCCCCCC | 31.22 | 27087446 | |
51 | Phosphorylation | KMNEEISSDSESESL CCCCCCCCCCCCCCC | 51.31 | 27087446 | |
53 | Phosphorylation | NEEISSDSESESLAP CCCCCCCCCCCCCCC | 44.99 | 27087446 | |
55 | Phosphorylation | EISSDSESESLAPRK CCCCCCCCCCCCCCC | 36.12 | 25168779 | |
57 | Phosphorylation | SSDSESESLAPRKTE CCCCCCCCCCCCCCH | 38.83 | 25168779 | |
63 | Phosphorylation | ESLAPRKTEEEEEEE CCCCCCCCHHHHHHH | 50.32 | 26370283 | |
84 | Acetylation | EKKLRLAKLYLEQLR HHHHHHHHHHHHHHH | 42.11 | 23806337 | |
169 | Phosphorylation | FSAAKDCTIIKWSVE HHHCCCCEEEEEECC | 35.55 | 18779572 | |
266 | Acetylation | TSHDRSVKVWNAAEN CCCCCCEEEEEHHHC | 42.66 | 7712905 | |
470 | Phosphorylation | PLRRLPVSPVAGS-- ECCCCCCCCCCCC-- | 16.24 | 27087446 | |
475 | Phosphorylation | PVSPVAGS------- CCCCCCCC------- | 27.58 | 25619855 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of U3IP2_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference |
---|---|---|---|---|
12 | K | Acetylation |
| - |
25 | K | Acetylation |
| - |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of U3IP2_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of U3IP2_MOUSE !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-470, AND MASSSPECTROMETRY. | |
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50; SER-51 AND SER-470,AND MASS SPECTROMETRY. | |
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50 AND SER-51, AND MASSSPECTROMETRY. |