dbPTM

U3IP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	U3IP2_MOUSE
UniProt AC	Q91WM3
Protein Name	U3 small nucleolar RNA-interacting protein 2
Gene Name	Rrp9
Organism	Mus musculus (Mouse).
Sequence Length	475
Subcellular Localization	Nucleus, nucleolus.
Protein Description	Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA..
Protein Sequence	MSTAVATRKRAKPAPGPGAAPVAGKRRRKVDSAADRGKSKGGGKMNEEISSDSESESLAPRKTEEEEEEELEETAQEKKLRLAKLYLEQLRQQEEEKAEARAFEEDQVAGRLKEDVLEQRGRLQKSVAKEIQAPAPTDIRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHVIPRAKKGAQGQPAGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRKGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLHGEPGLEQPFWVSSVAALLNTDLVATGSHNARVRLWQCGEGFRQLDPLCDIPLVGFINSLKFSSAGDFLVAGVGQEHRLGRWWRIKEARNSVCIIPLRRLPVSPVAGS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Methylation	TAVATRKRAKPAPGP CHHHCCCCCCCCCCC	44.55	-
12	Acetylation	VATRKRAKPAPGPGA HHCCCCCCCCCCCCC	45.83	-
25	Acetylation	GAAPVAGKRRRKVDS CCCCCCCCCCCCCCC	32.75	88787
26	Dimethylation	AAPVAGKRRRKVDSA CCCCCCCCCCCCCCH	42.59	-
26	Methylation	AAPVAGKRRRKVDSA CCCCCCCCCCCCCCH	42.59	18963549
27	Dimethylation	APVAGKRRRKVDSAA CCCCCCCCCCCCCHH	46.38	-
27	Methylation	APVAGKRRRKVDSAA CCCCCCCCCCCCCHH	46.38	18963559
50	Phosphorylation	GKMNEEISSDSESES CCCCCCCCCCCCCCC	31.22	27087446
51	Phosphorylation	KMNEEISSDSESESL CCCCCCCCCCCCCCC	51.31	27087446
53	Phosphorylation	NEEISSDSESESLAP CCCCCCCCCCCCCCC	44.99	27087446
55	Phosphorylation	EISSDSESESLAPRK CCCCCCCCCCCCCCC	36.12	25168779
57	Phosphorylation	SSDSESESLAPRKTE CCCCCCCCCCCCCCH	38.83	25168779
63	Phosphorylation	ESLAPRKTEEEEEEE CCCCCCCCHHHHHHH	50.32	26370283
84	Acetylation	EKKLRLAKLYLEQLR HHHHHHHHHHHHHHH	42.11	23806337
169	Phosphorylation	FSAAKDCTIIKWSVE HHHCCCCEEEEEECC	35.55	18779572
266	Acetylation	TSHDRSVKVWNAAEN CCCCCCEEEEEHHHC	42.66	7712905
470	Phosphorylation	PLRRLPVSPVAGS-- ECCCCCCCCCCCC--	16.24	27087446
475	Phosphorylation	PVSPVAGS------- CCCCCCCC-------	27.58	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of U3IP2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
12	K	Acetylation	-
Acetylation at Lys-12 and Lys-25 by KAT2B/PCAF under stress impairs pre-rRNA processing.
25	K	Acetylation	-
Acetylation at Lys-12 and Lys-25 by KAT2B/PCAF under stress impairs pre-rRNA processing.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of U3IP2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of U3IP2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of U3IP2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-470, AND MASSSPECTROMETRY.	19131326 [Abstract]
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50; SER-51 AND SER-470,AND MASS SPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50 AND SER-51, AND MASSSPECTROMETRY.	19367708 [Abstract]