CI114_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CI114_MOUSE
• UniProt AC: Q3UHX9
• Protein Name: Putative methyltransferase C9orf114 homolog {ECO:0000305}
• Gene Name: Spout1 {ECO:0000312|MGI:MGI:106544}
• Organism: Mus musculus (Mouse).
• Sequence Length: 385
• Subcellular Localization: Cytoplasm, cytoskeleton, spindle . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associated with the outer kinetochore.
• Protein Description: Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. Also involved in chromosome alignment. May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis. Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level (By similarity)..
• Protein Sequence: MAERPRKRPCGPGEHGQRVEWRKWKQQKKEEKKKWKDLKIMKKLERQRAQEEEAKRQEEEEEAAAQRSNQGRPYTLSVALPGSILDNAQSPELRTYLAGQIARACTIFCVDEIVVFDEEGQDTKSVEGEFRGVGKKGQACVQLARILQYLECPQYLRKAFFPKHQDLQFAGILNPLDSPHHMRQDEESEFREGVVVDRPTKAGHGSLVNCGMKKEVKIDKKLDPGLRVTVRLNQQQLPECKTYKGTVVSSQDPRTKAGLYWGYTVRLASCLSAVFAEAPFQDGYDLTIGTSERGSDVASAQLPSFRHALVVFGGLQGLEAAVDADPNLEVADPSVLFDFYVNTCLSQGSRTIRTEEAILISLAALQPGLTQVGSRPASPLSGPRM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
140	S-nitrosocysteine	VGKKGQACVQLARIL CCCHHHHHHHHHHHH	1.22	-
140	S-nitrosylation	VGKKGQACVQLARIL CCCHHHHHHHHHHHH	1.22	21278135
201	Ubiquitination	VVVDRPTKAGHGSLV CEECCCCCCCCCCCC	55.86	-
214	Ubiquitination	LVNCGMKKEVKIDKK CCCCCCCCEEECCCC	59.87	-
244	Malonylation	LPECKTYKGTVVSSQ CCCCEEEECEEEECC	54.02	26320211
334	Phosphorylation	NLEVADPSVLFDFYV CCCCCCHHHHHHHHH	31.81	24719451
354	Phosphorylation	QGSRTIRTEEAILIS CCCCEECHHHHHHHH	34.03	25367039
361	Phosphorylation	TEEAILISLAALQPG HHHHHHHHHHHCCCC	14.44	25367039
370	Phosphorylation	AALQPGLTQVGSRPA HHCCCCCCCCCCCCC	27.42	26824392
374	Phosphorylation	PGLTQVGSRPASPLS CCCCCCCCCCCCCCC	35.91	27087446
378	Phosphorylation	QVGSRPASPLSGPRM CCCCCCCCCCCCCCC	29.11	27087446
381	Phosphorylation	SRPASPLSGPRM--- CCCCCCCCCCCC---	50.57	27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CI114_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CI114_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CI114_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CI114_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.