dbPTM

TEX10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TEX10_MOUSE
UniProt AC	Q3URQ0
Protein Name	Testis-expressed protein 10
Gene Name	Tex10
Organism	Mus musculus (Mouse).
Sequence Length	928
Subcellular Localization	Nucleus, nucleolus . Nucleus, nucleoplasm . Cytoplasm . Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions.
Protein Description	Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. [PubMed: 22872859 Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity]
Protein Sequence	MTKKRKRQDDFQKVKLKVGKKKPKLENATATNFKTKAIHLPEQLKEDRTLPTNNRKLNIKDLLSQMHHYSGGVKQSALLGLKDLLSQYPFIIDAHLSNILSEVTAVFTDRDANVRLAAVQLLQFLAPKIRTEHISPFFPLVSAHLSSAMTHITEGIQEDSLKVLDILLEHYPALITGRSSILLKNFVELISHQQLSKGLVNRDRSQSWILSVNPNRRVTSQQWRLKVLARLSKFLQALADGSSRLRESEGLQEQKETPHATSNSIFINWKDHANDQQQIQVYENGGSQPNVSSQFRLRCLGTLGTVDEDLSSPENLKGFIEIIIPLLIECWIEALPPQLAASVGSGVEREPLQVMQQVLNVISLLWKLSKQQDETHTLESWLRKNYLTDFKHHFMSHFPYALKEITKQRKKDTNKSIKHCTVLSNNVDHLLLNLTLSDIMVSLANASTLQNDSSWIETIRKFVTETLKGGTRLNSKQLNRLLGVSWRLIQMQPNRDATENLIKAVYTLYQQRGLLLPVRTLLIKFFSKIYQKEELRSYRLRYRSKVLSRWLAGLPLQLSYLGSRNPELSTQLIDIIHTAASQANKDLLKNLQAAALRIYDPQEGAVVVLPAESQQRLVQLLYFLPTLPADLLSQLSRCCIMGRLGSSLAVTLIGILYMRSSFSGWSHSVNDCLMTDVDYLSFLFSTLTGFSKEELTWLQNLRGVPHVVQTSLSPVLLYLTDLDQFLHHWDITEAVCHSLLVIPARSQSFDIMQSAISKHLVGLTVIPDSTAGCIFGVMCKLLDHTCVVNEALLPFLASCCYSLLYFLLTLEKGDAEHLKKRDKLWEVCVSILALLPRVLRLMLQSLRVNRASPEELPVVGQLLRLLLQHVPLRSHMLTNAILVQQIIKNITTLKSGSVQEQWLTDLHYCFSVYISGHPQGPSILNALY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	KPKLENATATNFKTK CCCCCCCCCCCCCHH	45.67	-
76	Phosphorylation	YSGGVKQSALLGLKD HCCCHHHHHHHCHHH	18.37	28059163
128	Ubiquitination	LLQFLAPKIRTEHIS HHHHHCHHHCCCCCC	38.93	-
527	Phosphorylation	TLLIKFFSKIYQKEE HHHHHHHHHHHCHHH	22.67	30482847
589	Ubiquitination	QANKDLLKNLQAAAL HHCHHHHHHHHHHHH	64.01	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TEX10_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TEX10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TEX10_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TEX10_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TEX10_MOUSE

Related Literatures of Post-Translational Modification