IPO4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IPO4_MOUSE
• UniProt AC: Q8VI75
• Protein Name: Importin-4
• Gene Name: Ipo4
• Organism: Mus musculus (Mouse).
• Sequence Length: 1082
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. Acts as chaperone for exposed basic domains..
• Protein Sequence: MEPAGLEQILKELLLPDTERIRRATEQLQTILRDPAALPALFDLLATATDSQIRQFAAVLTRRRLNNRWRRLAPEQRESLKSLVLTALQKETVHSVSVSLAQLSATIFRKEGLQGWPQFMNLLQHSTHSSHSPEKEVGLLLLSVVVSSQPEAFHAHQHELLQLLNETLSDVSFPGVLFYSLRTLTAIARYVRPDDVSLARMLVPKVVTALRTLIPLDEVKACEALEALDEMLETELPIINPHLSEVLTFCLEVAKNVALGEPLRVRVLCCLTFLVKVKSKALLKNRLVPPLLHALFPLMAAEPPMGQLDPEDQDSDDDDLEIGLMGETPKHFAVQVVDMLALHLPPEKLCPHVMPMLEEALRSEDPYQRKAGFLVLAVLSDGAGDHIRQRLLYPLLQIVCKGLDDPSQIVRNAALFALGQFSENLQPHISSYSEEVMPLLLSYLKSVPMGNTHHLAKACYALENFVENLGPKVQPYLPELMECMLQPLKNPSKARTKELAVSAIGAIATAAQDSLLPYFPTIMDLLREFLLTGHEDFHLVQIQSLETLGVLARALGESMKPLAEECCQLGLGLCIHIDDPDVRRCTYSLFAALSGLMGEGLGPYLPQITTLMLLSLRSTEGIVPQYDGISSFLLFDDDSEAEEEEELMDEDMEEEGDDSEISGYSVENAFFDEKEDTCTALGEISMNTCVAFLPFMDATFDEVYKLLECPHMNVRKSAYEALGQFCCALHKASQRSSSDPSSSPVLQTSLARVMPAYMQAVKVERERPVVMAVLESLTGVLRTCGSLALQPPGRLSELCNVLKAVLQKKTACQDAEEDDDEDDDQAEYDAMLLEHAGEAIPVLAATAGGHAFAPFFATFLPLLLCKTKQSCTVAEKSFAVGTLAESIQGLGTASAQFVSRLFPVLLNNAREADPEVRSNAIFGLGVLAEHGGCPAQDHFPKLLGLLLPLLARERHDRVRDNICGALARVLMASPVGKTEPQVLATLLRALPLKEDMEEWLTIGHLFSFLHQNNPEQVVDVASELLRICSLILPDNRIPPDTKAALLLLLTFLAKQHTDSFHTALGSLPNDKAQELQAMMGLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEPAGLEQ -------CCCCCHHH	53.63	-
18	Phosphorylation	KELLLPDTERIRRAT HHHCCCCHHHHHHHH	25.81	21454597
79	Phosphorylation	LAPEQRESLKSLVLT CCHHHHHHHHHHHHH	43.20	-
197	Phosphorylation	YVRPDDVSLARMLVP HCCCCCCHHHHHHHH	24.25	25338131
205	Ubiquitination	LARMLVPKVVTALRT HHHHHHHHHHHHHHH	41.69	22790023
401	Ubiquitination	PLLQIVCKGLDDPSQ HHHHHHHCCCCCHHH	52.17	-
502	Phosphorylation	RTKELAVSAIGAIAT HHHHHHHHHHHHHHH	14.46	-
518	Phosphorylation	AQDSLLPYFPTIMDL HHHCCHHHHHHHHHH	23.35	-
521	Phosphorylation	SLLPYFPTIMDLLRE CCHHHHHHHHHHHHH	21.02	-
659	Phosphorylation	MEEEGDDSEISGYSV HHHHCCCCCCCCCEE	41.38	-
662	Phosphorylation	EGDDSEISGYSVENA HCCCCCCCCCEECCC	27.85	-
664	Phosphorylation	DDSEISGYSVENAFF CCCCCCCCEECCCCC	11.62	-
726	Glutathionylation	YEALGQFCCALHKAS HHHHHHHHHHHHHHH	0.73	24333276
727	Glutathionylation	EALGQFCCALHKASQ HHHHHHHHHHHHHHH	4.82	24333276
741	Phosphorylation	QRSSSDPSSSPVLQT HCCCCCCCCCHHHHH	48.73	25293948
742	Phosphorylation	RSSSDPSSSPVLQTS CCCCCCCCCHHHHHH	44.01	25293948
743	Phosphorylation	SSSDPSSSPVLQTSL CCCCCCCCHHHHHHH	24.30	25293948
757	Phosphorylation	LARVMPAYMQAVKVE HHHHHHHHHHHHHCC	5.49	-
762	Ubiquitination	PAYMQAVKVERERPV HHHHHHHHCCCCCHH	41.20	22790023
977	Ubiquitination	LMASPVGKTEPQVLA HHHCCCCCCCHHHHH	50.37	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IPO4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IPO4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IPO4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IPO4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.