dbPTM

DKC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DKC1_MOUSE
UniProt AC	Q9ESX5
Protein Name	H/ACA ribonucleoprotein complex subunit DKC1
Gene Name	Dkc1
Organism	Mus musculus (Mouse).
Sequence Length	509
Subcellular Localization	Nucleus, nucleolus . Nucleus, Cajal body . Also localized to Cajal bodies (coiled bodies).
Protein Description	Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. [PubMed: 12522253]
Protein Sequence	MADAEVITFPKKHKKKKDRKPLQEDDVAEIQHAEEFLIKPESKVAQLDTSQWPLLLKNFDKLNVRTAHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKMMIKQGLLDKHGKPTDNTPATWKQDYIDYSDSGKNTLVTEAVQAPQLAAEAVNVIKRKRDSESESDETPTVPQLKEKKKKKDKKPKTVLESGGETGDGDNDTTKKKKKKKVKVVEEMSE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADAEVITF ------CCCCEEECC	25.40	-
42	Phosphorylation	EFLIKPESKVAQLDT HHHCCCHHHCCCCCC	40.74	26745281
80	Malonylation	PCGSNPLKREIGDYI CCCCCCCHHHHHHHH	49.60	26320211
89	Phosphorylation	EIGDYIRTGFINLDK HHHHHHHHCCCCCCC	27.21	22817900
98	Phosphorylation	FINLDKPSNPSSHEV CCCCCCCCCCCHHHH	68.09	22817900
102	Phosphorylation	DKPSNPSSHEVVAWI CCCCCCCHHHHHHHH	25.56	22817900
118	Phosphorylation	RILRVEKTGHSGTLD HHHCHHCCCCCCCCC	26.99	-
121	Phosphorylation	RVEKTGHSGTLDPKV CHHCCCCCCCCCCCC	34.51	-
123	Phosphorylation	EKTGHSGTLDPKVTG HCCCCCCCCCCCCCE	30.88	-
376	Phosphorylation	VIMERDTYPRKWGLG HHHCCCCCCCCCCCC	12.82	-
387	Phosphorylation	WGLGPKASQKKMMIK CCCCCCHHHHHHHHH	48.97	-
389	Acetylation	LGPKASQKKMMIKQG CCCCHHHHHHHHHCC	39.89	15620307
394	Malonylation	SQKKMMIKQGLLDKH HHHHHHHHCCCHHCC	22.03	26320211
416	Phosphorylation	PATWKQDYIDYSDSG CCCCCCCEEECCCCC	8.00	21183079
419	Phosphorylation	WKQDYIDYSDSGKNT CCCCEEECCCCCCCE	12.57	25619855
420	Phosphorylation	KQDYIDYSDSGKNTL CCCEEECCCCCCCEE	22.88	25521595
422	Phosphorylation	DYIDYSDSGKNTLVT CEEECCCCCCCEEEE	45.81	25619855
451	Phosphorylation	VIKRKRDSESESDET HHHHHCCCCCCCCCC	47.24	27087446
453	Phosphorylation	KRKRDSESESDETPT HHHCCCCCCCCCCCC	46.48	27087446
455	Phosphorylation	KRDSESESDETPTVP HCCCCCCCCCCCCHH	50.45	27087446
458	Phosphorylation	SESESDETPTVPQLK CCCCCCCCCCHHHHH	29.29	21082442
460	Phosphorylation	SESDETPTVPQLKEK CCCCCCCCHHHHHHH	52.84	22802335
477	Phosphorylation	KKDKKPKTVLESGGE CCCCCCCEEHHCCCC	38.56	25521595
481	Phosphorylation	KPKTVLESGGETGDG CCCEEHHCCCCCCCC	48.19	27087446
485	Phosphorylation	VLESGGETGDGDNDT EHHCCCCCCCCCCCC	43.79	25521595
492	Phosphorylation	TGDGDNDTTKKKKKK CCCCCCCCCHHHHHH	46.93	25619855
493	Phosphorylation	GDGDNDTTKKKKKKK CCCCCCCCHHHHHHC	43.67	25619855
508	Phosphorylation	VKVVEEMSE------ CEEECCCCC------	43.35	27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DKC1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DKC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DKC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DKC1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DKC1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-451; SER-453; SER-455AND SER-508, AND MASS SPECTROMETRY.	19131326 [Abstract]
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-508, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-451; SER-453 ANDTHR-458, AND MASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-451; SER-453 ANDSER-481, AND MASS SPECTROMETRY.	17242355 [Abstract]
"A differential phosphoproteomic analysis of retinoic acid-treated P19cells."; Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.; J. Proteome Res. 6:3174-3186(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-451; SER-453 ANDSER-455, AND MASS SPECTROMETRY.	17622165 [Abstract]
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481, AND MASSSPECTROMETRY.	17203969 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-508, AND MASSSPECTROMETRY.	16452087 [Abstract]