RBP2_MOUSE - dbPTM
RBP2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RBP2_MOUSE
UniProt AC Q9ERU9
Protein Name E3 SUMO-protein ligase RanBP2
Gene Name Ranbp2
Organism Mus musculus (Mouse).
Sequence Length 3053
Subcellular Localization Nucleus . Nucleus membrane . Nucleus, nuclear pore complex . Nucleus envelope . Detected in diffuse and discrete intranuclear foci. Cytoplasmic filaments.
Protein Description E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1 (By similarity). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity..
Protein Sequence MRRSKADVERYIASVQGSAPSPREKSMKGFYFAKLYYEAKEYDLAKKYISTYINVQERDPKAHRFLGLLYEVEENIDKAVECYKRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWVERAAKLFPGSPAIYKLKEQLLDCKGEDGWNKLFDLIQSELYARPDDIHVNIRLVELYRSNKRLKDAVAHCHEADRNTALRSSLEWNLCVVQTLKEYLESLQCLDSDKSTWRATNKDLLLAYANLMLLTLSTRDVQEGRELLESFDSALQSVKSSVGGNDELSATFLETKGHFYMHVGSLLLKMGQQSDIQWRALSELAALCYLVAFQVPRPKVKLIKGEAGQNLLETMAHDRLSQSGHMLLNLSRGKQDFLKEVVESFANKSGQSALCDALFSSQSSKERSFLGNDDIGNLDGQVPDPDDLARYDTGAVRAHNGSLQHLTWLGLQWNSLSTLPAIRKWLKQLFHHLPQETSRLETNAPESICILDLEVFLLGVIYTSHLQLKEKCNSHHTSYQPLCLPLPVCRQLCTERQKTWWDAVCTLIHRKALPGTSAKLRLLVQREINSLRGQEKHGLQPALLVHWAQSLQKTGSSLNSFYDQREYIGRSVHYWRKVLPLLKMIRKKNSIPEPIDPLFKHFHSVDIQASEIGEYEEDAHITFAILDAVNGNIEDAMTAFESIKNVVSYWNLALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIRILDDSDSNTSVVQKLPVPLESVKEMLNSVMQELEDYSEGGTLYKNGCWRSADSELKHSTPSPTKYSLSPSKSYKYSPKTPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSNNSASPHRWPAEPYGQDPAPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGPVYGMNRLPPQQHIYAYSQQMHTPPVQSSSACMFSQEMYGPPLRFESPATGILSPRGDDYFNYNVQQTSTNPPLPEPGYFTKPPLVAHASRSAESKVIEFGKSNFVQPMQGEVIRPPLTTPAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVAQPPSTAYSNSESLLGLLTSDKPLQGDGYSGLKPISGQASGSRNTFSFGSKNTLTENMGPNQQKNFGFHRSDDMFAFHGPGKSVFTTAASELANKSHETDGGSAHGDEEDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAKLFRFDGESKEWKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGSDRSFVWHALDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQNILKALGTNTSTAPNHTLRIVKESATQDNKDICKADGGNLNFEFQIVKKEGPYWNCNSCSFKNAATAKKCVSCQNTNPTSNKELLGPPLVENGFAPKTGLENAQDRFATMTANKEGHWDCSVCLVRNEPTVSRCIACQNTKSASSFVQTSFKFGQGDLPKSVDSDFRSVFSKKEGQWECSVCLVRNERSAKKCVACENPGKQFKEWHCSLCSVKNEAHAIKCVACNNPVTPSLSTAPPSFKFGTSEMSKPFRIGFEGMFAKKEGQWDCSLCFVRNEASATHCIACQYPNKQNQPTSCVSAPASSETSRSPKSGFEGLFPKKEGEWECAVCSVQNESSSLKCVACEASKPTHKPHEAPSAFTVGSKSQSNESAGSQVGTEFKSNFPEKNFKVGISEQKFKFGHVDQEKTPSFAFQGGSNTEFKSIKDGFSFCIPVSADGFKFGIQEKGNQEKKSEKHLENDPSFQAHDTSGQKNGSGVVFGQTSSTFTFADLAKSTSREGFQFGKKDPNFKGFSGAGEKLFSSQSGKVAEKANTSSDLEKDDDAYKTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRVKLFRFDAEISQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSGSDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTNDQVKVTDEENASSGADAPSASDTTAKQNPDNTGPALEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFRFGESTTGFNFSFKSALSPSKSPAKLNQSGASVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLYRYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQTMKGTERVWVWTACDFADGERKIEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSHLSTPRESPCGKIAIAVLEETTRERTDLTQGDEVIDTTSEAGETSSTSETTPKAVVSPPKFVFGSESVKSIFSSEKSKPFAFGNSSATGSLFGFSFNAPLKNSNSEMTSRVQSGSEGKVKPDKCELPQNSDIKQSSDGKVKNLSAFSKENSSTSYTFKTPEKAQEKSKPEDLPSDNDILIVYELTPTPEQKALAEKLLLPSTFFCYKNRPGYVSEEEEDDEDYEMAVKKLNGKLYLDDSEKPLEENLADNDKECVIVWEKKPTVEERAKADTLKLPPTFFCGVCSDTDEDNGNGEDFQSELRKVCEAQKSQNEKVTDRVGIEHIGETEVTNPVGCKSEEPDSDTKHSSSSPVSGTMDKPVDLSTRKETDMEFPSKGENKPVLFGFGSGTGLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQTTSKGGEDEDGSDEDVVHNEDIHFEPIVSLPEVEVKSGEEDEEVLFKERAKLYRWDRDVSQWKERGIGDIKILWHTMKKYYRILMRRDQVFKVCANHVITKAMELKPLNVSNNALVWTASDYADGEAKVEQLAVRFKTKEMTESFKKKFEECQQNIIKLQNGHTSLAAELSKDTNPVVFFDVCADGEPLGRIIMELFSNIVPQTAENFRALCTGEKGFGFKNSIFHRVVPDFICQGGDITKYNGTGGQSIYGDKFDDENFDLKHTGPGLLSMANYGQNTNSSQFFITLKKAEHLDFKHVVFGFVKDGMDTVRKIESFGSPKGSVSRRICITECGQL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationSKADVERYIASVQGS
CHHHHHHHHHHHCCC
6.3225619855
14PhosphorylationDVERYIASVQGSAPS
HHHHHHHHHCCCCCC
12.8625619855
18PhosphorylationYIASVQGSAPSPREK
HHHHHCCCCCCHHHH
21.6625619855
21PhosphorylationSVQGSAPSPREKSMK
HHCCCCCCHHHHHCC
35.9826824392
50PhosphorylationDLAKKYISTYINVQE
HHHHHHHHHHCCHHH
16.4529472430
51PhosphorylationLAKKYISTYINVQER
HHHHHHHHHCCHHHC
20.8929472430
52PhosphorylationAKKYISTYINVQERD
HHHHHHHHCCHHHCC
5.4529472430
128PhosphorylationAAKLFPGSPAIYKLK
HHHHCCCCHHHHHHH
16.0526745281
132PhosphorylationFPGSPAIYKLKEQLL
CCCCHHHHHHHHHHH
16.6326643407
175PhosphorylationNIRLVELYRSNKRLK
EHHHHHHHHCCCCHH
9.8629472430
177PhosphorylationRLVELYRSNKRLKDA
HHHHHHHCCCCHHHH
32.9029472430
225UbiquitinationLQCLDSDKSTWRATN
CCCCCCCHHHHHHCC
54.4522790023
335UbiquitinationRPKVKLIKGEAGQNL
CCCCEEEECCHHHHH
62.2222790023
352PhosphorylationTMAHDRLSQSGHMLL
HHHHHHHHHHCCHHH
24.1629472430
354PhosphorylationAHDRLSQSGHMLLNL
HHHHHHHHCCHHHHC
27.5629472430
362PhosphorylationGHMLLNLSRGKQDFL
CCHHHHCCCCCHHHH
37.6029472430
379UbiquitinationVVESFANKSGQSALC
HHHHHCCCCCHHHHH
53.1622790023
396UbiquitinationLFSSQSSKERSFLGN
HHCCCCHHHHHCCCC
63.4922790023
550UbiquitinationALPGTSAKLRLLVQR
CCCCCHHHHHHHHHH
33.6327667366
756PhosphorylationVMQELEDYSEGGTLY
HHHHHHHHCCCCCEE
10.1525159016
757PhosphorylationMQELEDYSEGGTLYK
HHHHHHHCCCCCEEE
41.9325159016
770PhosphorylationYKNGCWRSADSELKH
EECCCCCCCCCCCCC
16.3625777480
773PhosphorylationGCWRSADSELKHSTP
CCCCCCCCCCCCCCC
44.5421183079
778PhosphorylationADSELKHSTPSPTKY
CCCCCCCCCCCCCCC
40.1927149854
779PhosphorylationDSELKHSTPSPTKYS
CCCCCCCCCCCCCCC
27.7523684622
781PhosphorylationELKHSTPSPTKYSLS
CCCCCCCCCCCCCCC
45.3426824392
783PhosphorylationKHSTPSPTKYSLSPS
CCCCCCCCCCCCCCC
47.1323335269
785PhosphorylationSTPSPTKYSLSPSKS
CCCCCCCCCCCCCCC
19.8125159016
786PhosphorylationTPSPTKYSLSPSKSY
CCCCCCCCCCCCCCC
24.7525168779
788PhosphorylationSPTKYSLSPSKSYKY
CCCCCCCCCCCCCCC
22.6125521595
790PhosphorylationTKYSLSPSKSYKYSP
CCCCCCCCCCCCCCC
30.7521082442
792PhosphorylationYSLSPSKSYKYSPKT
CCCCCCCCCCCCCCC
31.0625159016
793PhosphorylationSLSPSKSYKYSPKTP
CCCCCCCCCCCCCCC
20.0625777480
795PhosphorylationSPSKSYKYSPKTPPR
CCCCCCCCCCCCCCC
23.2125159016
796PhosphorylationPSKSYKYSPKTPPRW
CCCCCCCCCCCCCCH
18.7723684622
798UbiquitinationKSYKYSPKTPPRWAE
CCCCCCCCCCCCHHH
68.6627667366
799PhosphorylationSYKYSPKTPPRWAED
CCCCCCCCCCCHHHC
41.7425521595
809PhosphorylationRWAEDQNSLLKMICQ
CHHHCHHHHHHHHHH
29.4625266776
832PhosphorylationMQELKLNSNNSASPH
HHHHHCCCCCCCCCC
48.0725159016
835PhosphorylationLKLNSNNSASPHRWP
HHCCCCCCCCCCCCC
34.0825159016
837PhosphorylationLNSNNSASPHRWPAE
CCCCCCCCCCCCCCC
22.5126824392
896PhosphorylationLRPAANVTPTKGPVY
EEECCCCCCCCCCCC
25.6629472430
898PhosphorylationPAANVTPTKGPVYGM
ECCCCCCCCCCCCCC
38.9929472430
903PhosphorylationTPTKGPVYGMNRLPP
CCCCCCCCCCCCCCC
17.5025159016
915PhosphorylationLPPQQHIYAYSQQMH
CCCHHHHHEEECCCC
9.4322802335
944Asymmetric dimethylarginineEMYGPPLRFESPATG
HHHCCCCCCCCCCCC
38.77-
944MethylationEMYGPPLRFESPATG
HHHCCCCCCCCCCCC
38.77-
947PhosphorylationGPPLRFESPATGILS
CCCCCCCCCCCCCCC
19.6821082442
950PhosphorylationLRFESPATGILSPRG
CCCCCCCCCCCCCCC
28.3025619855
954PhosphorylationSPATGILSPRGDDYF
CCCCCCCCCCCCCCC
15.6125521595
960PhosphorylationLSPRGDDYFNYNVQQ
CCCCCCCCCCCCCCC
9.8525159016
990PhosphorylationPPLVAHASRSAESKV
CCCEEECCCCCCCHH
19.5322324799
996AcetylationASRSAESKVIEFGKS
CCCCCCCHHHCCCCC
38.4423806337
1015Asymmetric dimethylargininePMQGEVIRPPLTTPA
CCCCCEECCCCCCCC
31.77-
1015MethylationPMQGEVIRPPLTTPA
CCCCCEECCCCCCCC
31.7724129315
1038PhosphorylationKFNSNFKSNDGDFTF
CCCCCCCCCCCCCEE
35.7026643407
1044PhosphorylationKSNDGDFTFSSPQVV
CCCCCCCEECCCEEE
27.6126643407
1046PhosphorylationNDGDFTFSSPQVVAQ
CCCCCEECCCEEEEC
37.7426643407
1047PhosphorylationDGDFTFSSPQVVAQP
CCCCEECCCEEEECC
18.3726643407
1096PhosphorylationQASGSRNTFSFGSKN
CCCCCCCCCCCCCCC
21.3928066266
1098PhosphorylationSGSRNTFSFGSKNTL
CCCCCCCCCCCCCCC
27.0223684622
1101PhosphorylationRNTFSFGSKNTLTEN
CCCCCCCCCCCCCCC
22.2625521595
1104PhosphorylationFSFGSKNTLTENMGP
CCCCCCCCCCCCCCC
38.5019060867
1106PhosphorylationFGSKNTLTENMGPNQ
CCCCCCCCCCCCCCC
24.2325367039
1122PhosphorylationKNFGFHRSDDMFAFH
CCCCCCCCCCEEEEC
29.4123684622
1134PhosphorylationAFHGPGKSVFTTAAS
EECCCCCHHHHHHHH
28.5125367039
1137O-linked_GlycosylationGPGKSVFTTAASELA
CCCCHHHHHHHHHHH
17.2330059200
1137PhosphorylationGPGKSVFTTAASELA
CCCCHHHHHHHHHHH
17.2325367039
1138O-linked_GlycosylationPGKSVFTTAASELAN
CCCHHHHHHHHHHHC
14.5730059200
1138PhosphorylationPGKSVFTTAASELAN
CCCHHHHHHHHHHHC
14.5721183079
1141PhosphorylationSVFTTAASELANKSH
HHHHHHHHHHHCCCC
30.5825521595
1147PhosphorylationASELANKSHETDGGS
HHHHHCCCCCCCCCC
26.7725521595
1150PhosphorylationLANKSHETDGGSAHG
HHCCCCCCCCCCCCC
34.2225521595
1154PhosphorylationSHETDGGSAHGDEED
CCCCCCCCCCCCCCC
23.7127087446
1214MalonylationERGIGNVKILRHKTS
HCCCCCEEEEEECCC
39.7726320211
1214UbiquitinationERGIGNVKILRHKTS
HCCCCCEEEEEECCC
39.7727667366
1243PhosphorylationICANHYISPDMKLTP
HHHHCCCCCCCCCCC
14.0023608596
1306O-linked_GlycosylationLKALGTNTSTAPNHT
HHHHCCCCCCCCCHH
27.5630059200
1307O-linked_GlycosylationKALGTNTSTAPNHTL
HHHCCCCCCCCCHHE
25.3330059200
1349PhosphorylationIVKKEGPYWNCNSCS
EEECCCCCCCCCCCC
21.8020116462
1376PhosphorylationCQNTNPTSNKELLGP
CCCCCCCCCHHHCCC
47.3521183079
1407PhosphorylationQDRFATMTANKEGHW
HHHHHHCCCCCCCCE
23.79-
1438PhosphorylationIACQNTKSASSFVQT
EEECCCCCCHHHCHH
31.2028725479
1440PhosphorylationCQNTKSASSFVQTSF
ECCCCCCHHHCHHHE
31.2526745281
1441PhosphorylationQNTKSASSFVQTSFK
CCCCCCHHHCHHHEE
29.2022817900
1445PhosphorylationSASSFVQTSFKFGQG
CCHHHCHHHEECCCC
30.7229176673
1446PhosphorylationASSFVQTSFKFGQGD
CHHHCHHHEECCCCC
14.8924719451
1457PhosphorylationGQGDLPKSVDSDFRS
CCCCCCCCCCCCHHH
29.2629514104
1476PhosphorylationKEGQWECSVCLVRNE
CCCEEEEEEEEEECH
12.3528066266
1526PhosphorylationVACNNPVTPSLSTAP
EECCCCCCCCCCCCC
14.3930352176
1528PhosphorylationCNNPVTPSLSTAPPS
CCCCCCCCCCCCCCC
26.1126745281
1530PhosphorylationNPVTPSLSTAPPSFK
CCCCCCCCCCCCCCC
27.1928066266
1531PhosphorylationPVTPSLSTAPPSFKF
CCCCCCCCCCCCCCC
48.7728066266
1535PhosphorylationSLSTAPPSFKFGTSE
CCCCCCCCCCCCCCC
39.7523984901
1545AcetylationFGTSEMSKPFRIGFE
CCCCCCCCCEEEEEC
47.0323954790
1591PhosphorylationPNKQNQPTSCVSAPA
CCCCCCCCCCEECCC
25.6225619855
1592PhosphorylationNKQNQPTSCVSAPAS
CCCCCCCCCEECCCC
21.1425619855
1595PhosphorylationNQPTSCVSAPASSET
CCCCCCEECCCCCCC
32.6325619855
1599PhosphorylationSCVSAPASSETSRSP
CCEECCCCCCCCCCC
27.8723684622
1600PhosphorylationCVSAPASSETSRSPK
CEECCCCCCCCCCCC
47.1823684622
1602PhosphorylationSAPASSETSRSPKSG
ECCCCCCCCCCCCCC
31.2423684622
1603PhosphorylationAPASSETSRSPKSGF
CCCCCCCCCCCCCCC
27.0625521595
1605PhosphorylationASSETSRSPKSGFEG
CCCCCCCCCCCCCCC
36.1325521595
1608PhosphorylationETSRSPKSGFEGLFP
CCCCCCCCCCCCCCC
52.6923984901
1662PhosphorylationAFTVGSKSQSNESAG
CEECCCCCCCCCCCC
40.3030352176
1664PhosphorylationTVGSKSQSNESAGSQ
ECCCCCCCCCCCCCC
50.0527841257
1670PhosphorylationQSNESAGSQVGTEFK
CCCCCCCCCCCCHHH
22.78-
1695SumoylationGISEQKFKFGHVDQE
EECCCEEECCCCCCC
58.4328289178
1706PhosphorylationVDQEKTPSFAFQGGS
CCCCCCCCCCCCCCC
34.14-
1731O-linked_GlycosylationFSFCIPVSADGFKFG
EEEEEEECCCCCEEC
18.4529407155
1758PhosphorylationKHLENDPSFQAHDTS
HHHCCCCCCCCCCCC
32.6229550500
1764PhosphorylationPSFQAHDTSGQKNGS
CCCCCCCCCCCCCCC
25.5329550500
1765PhosphorylationSFQAHDTSGQKNGSG
CCCCCCCCCCCCCCC
45.3329550500
1790PhosphorylationTFADLAKSTSREGFQ
EHHHHHHHCCCCCCC
26.4723684622
1791PhosphorylationFADLAKSTSREGFQF
HHHHHHHCCCCCCCC
30.9728066266
1792PhosphorylationADLAKSTSREGFQFG
HHHHHHCCCCCCCCC
35.1130352176
1814AcetylationGFSGAGEKLFSSQSG
CCCCCCHHHHCCCCC
54.6523806337
1820PhosphorylationEKLFSSQSGKVAEKA
HHHHCCCCCHHHHHC
42.3929514104
1829PhosphorylationKVAEKANTSSDLEKD
HHHHHCCCCCCCCCC
34.1723429704
1830PhosphorylationVAEKANTSSDLEKDD
HHHHCCCCCCCCCCC
22.9721082442
1831PhosphorylationAEKANTSSDLEKDDD
HHHCCCCCCCCCCCC
44.1425521595
1840PhosphorylationLEKDDDAYKTEDSDD
CCCCCCCCCCCCCCC
25.9921149613
1842PhosphorylationKDDDAYKTEDSDDIH
CCCCCCCCCCCCCCC
32.1423684622
1845PhosphorylationDAYKTEDSDDIHFEP
CCCCCCCCCCCCCEE
30.8323684622
1898UbiquitinationERGLGNLKILKNEVN
HCCCCCCEEHHHHHH
50.4122790023
1962UbiquitinationKLEQLAAKFKTPELA
HHHHHHHHHCCHHHH
41.6122790023
1990PhosphorylationLLDIPLQTPHKLVDT
HHCCCCCCCCHHCHH
34.7326824392
1997PhosphorylationTPHKLVDTGRAAKLI
CCCHHCHHHHHHHHH
22.53-
2012PhosphorylationQRAEEMKSGLKDFKT
HHHHHHHHCCCHHHH
48.3126824392
2018SumoylationKSGLKDFKTFLTNDQ
HHCCCHHHHHHHCCC
48.8028289178
2029PhosphorylationTNDQVKVTDEENASS
HCCCEEECCCCHHCC
31.7930635358
2035PhosphorylationVTDEENASSGADAPS
ECCCCHHCCCCCCCC
40.6730352176
2036PhosphorylationTDEENASSGADAPSA
CCCCHHCCCCCCCCC
35.2725521595
2042PhosphorylationSSGADAPSASDTTAK
CCCCCCCCCCCCCCC
41.9730635358
2044PhosphorylationGADAPSASDTTAKQN
CCCCCCCCCCCCCCC
39.5730635358
2046PhosphorylationDAPSASDTTAKQNPD
CCCCCCCCCCCCCCC
26.5930635358
2055PhosphorylationAKQNPDNTGPALEWD
CCCCCCCCCCCCCCC
52.5028066266
2074PhosphorylationREDALDDSVSSSSVH
CHHHCCCCCCCCCCC
24.4627742792
2076PhosphorylationDALDDSVSSSSVHAS
HHCCCCCCCCCCCCC
28.5827742792
2077PhosphorylationALDDSVSSSSVHASP
HCCCCCCCCCCCCCC
25.2027742792
2078PhosphorylationLDDSVSSSSVHASPL
CCCCCCCCCCCCCCC
28.9527742792
2079PhosphorylationDDSVSSSSVHASPLA
CCCCCCCCCCCCCCC
21.6227087446
2083PhosphorylationSSSSVHASPLASSPV
CCCCCCCCCCCCCCC
12.9327087446
2087PhosphorylationVHASPLASSPVRKNL
CCCCCCCCCCCCCCC
42.7427087446
2088PhosphorylationHASPLASSPVRKNLF
CCCCCCCCCCCCCCH
23.0827087446
2100PhosphorylationNLFRFGESTTGFNFS
CCHHCCCCCCCCCCC
31.4830352176
2101PhosphorylationLFRFGESTTGFNFSF
CHHCCCCCCCCCCCC
27.0021659604
2107PhosphorylationSTTGFNFSFKSALSP
CCCCCCCCCCCCCCC
32.6326824392
2110PhosphorylationGFNFSFKSALSPSKS
CCCCCCCCCCCCCCC
32.2225159016
2113PhosphorylationFSFKSALSPSKSPAK
CCCCCCCCCCCCCCC
27.1826824392
2115PhosphorylationFKSALSPSKSPAKLN
CCCCCCCCCCCCCCC
42.2527566939
2117PhosphorylationSALSPSKSPAKLNQS
CCCCCCCCCCCCCCC
34.1326824392
2124PhosphorylationSPAKLNQSGASVGTD
CCCCCCCCCCCCCCC
34.9425619855
2127PhosphorylationKLNQSGASVGTDEES
CCCCCCCCCCCCCCC
25.3021082442
2130PhosphorylationQSGASVGTDEESDVT
CCCCCCCCCCCCCCC
37.7725521595
2134PhosphorylationSVGTDEESDVTQEEE
CCCCCCCCCCCCHHH
35.0225521595
2137PhosphorylationTDEESDVTQEEERDG
CCCCCCCCCHHHCCC
34.9425619855
2278PhosphorylationKIFDEAKTAQEKDSL
HHHHHHHHHHHHHCC
40.3925777480
2284PhosphorylationKTAQEKDSLITPHVS
HHHHHHHCCCCCCCH
32.5125619855
2287PhosphorylationQEKDSLITPHVSHLS
HHHHCCCCCCCHHCC
16.7925619855
2291PhosphorylationSLITPHVSHLSTPRE
CCCCCCCHHCCCCCC
18.7125168779
2294PhosphorylationTPHVSHLSTPRESPC
CCCCHHCCCCCCCCC
30.8327087446
2295PhosphorylationPHVSHLSTPRESPCG
CCCHHCCCCCCCCCC
32.5027087446
2299PhosphorylationHLSTPRESPCGKIAI
HCCCCCCCCCCHHHH
27.1127087446
2317PhosphorylationEETTRERTDLTQGDE
HHHCCCCCCCCCCCE
30.5225619855
2320PhosphorylationTRERTDLTQGDEVID
CCCCCCCCCCCEEEE
33.0625619855
2328PhosphorylationQGDEVIDTTSEAGET
CCCEEEECCCCCCCC
22.5425619855
2329PhosphorylationGDEVIDTTSEAGETS
CCEEEECCCCCCCCC
22.3325619855
2330PhosphorylationDEVIDTTSEAGETSS
CEEEECCCCCCCCCC
27.7825521595
2335PhosphorylationTTSEAGETSSTSETT
CCCCCCCCCCCCCCC
27.3625619855
2336PhosphorylationTSEAGETSSTSETTP
CCCCCCCCCCCCCCC
27.5825619855
2337PhosphorylationSEAGETSSTSETTPK
CCCCCCCCCCCCCCC
43.2925619855
2338PhosphorylationEAGETSSTSETTPKA
CCCCCCCCCCCCCCE
30.2825619855
2339PhosphorylationAGETSSTSETTPKAV
CCCCCCCCCCCCCEE
34.5925619855
2341PhosphorylationETSSTSETTPKAVVS
CCCCCCCCCCCEEEC
48.4427087446
2342PhosphorylationTSSTSETTPKAVVSP
CCCCCCCCCCEEECC
20.8125521595
2348PhosphorylationTTPKAVVSPPKFVFG
CCCCEEECCCCEECC
28.9626824392
2356PhosphorylationPPKFVFGSESVKSIF
CCCEECCCHHHHHHH
18.4225619855
2358PhosphorylationKFVFGSESVKSIFSS
CEECCCHHHHHHHCC
36.2225619855
2364PhosphorylationESVKSIFSSEKSKPF
HHHHHHHCCCCCCCC
35.6021454597
2365PhosphorylationSVKSIFSSEKSKPFA
HHHHHHCCCCCCCCE
37.9928066266
2368PhosphorylationSIFSSEKSKPFAFGN
HHHCCCCCCCCEECC
41.3223984901
2376PhosphorylationKPFAFGNSSATGSLF
CCCEECCCCCCCCCC
23.0223984901
2377PhosphorylationPFAFGNSSATGSLFG
CCEECCCCCCCCCCE
33.5723984901
2379PhosphorylationAFGNSSATGSLFGFS
EECCCCCCCCCCEEE
29.2923984901
2381PhosphorylationGNSSATGSLFGFSFN
CCCCCCCCCCEEEEC
19.0323984901
2386PhosphorylationTGSLFGFSFNAPLKN
CCCCCEEEECCCCCC
20.2623984901
2411SumoylationSGSEGKVKPDKCELP
CCCCCCCCCCCCCCC
51.4928289178
2424SumoylationLPQNSDIKQSSDGKV
CCCCCCCCCCCCCCE
49.4728289178
2435PhosphorylationDGKVKNLSAFSKENS
CCCEEEHHHCCCCCC
36.3425338131
2438PhosphorylationVKNLSAFSKENSSTS
EEEHHHCCCCCCCCC
38.4828725479
2442PhosphorylationSAFSKENSSTSYTFK
HHCCCCCCCCCEEEC
35.7625619855
2443PhosphorylationAFSKENSSTSYTFKT
HCCCCCCCCCEEECC
32.7125619855
2444PhosphorylationFSKENSSTSYTFKTP
CCCCCCCCCEEECCH
26.1025619855
2445PhosphorylationSKENSSTSYTFKTPE
CCCCCCCCEEECCHH
24.9125619855
2446PhosphorylationKENSSTSYTFKTPEK
CCCCCCCEEECCHHH
19.1125619855
2447PhosphorylationENSSTSYTFKTPEKA
CCCCCCEEECCHHHH
20.5825619855
2450PhosphorylationSTSYTFKTPEKAQEK
CCCEEECCHHHHHHH
32.2722942356
2496S-palmitoylationLLPSTFFCYKNRPGY
HCCCEEEECCCCCCC
4.0628526873
2503PhosphorylationCYKNRPGYVSEEEED
ECCCCCCCCCCCCCC
11.9527742792
2505PhosphorylationKNRPGYVSEEEEDDE
CCCCCCCCCCCCCCC
30.7027087446
2514PhosphorylationEEEDDEDYEMAVKKL
CCCCCCCHHHHHHHH
12.9325619855
2563PhosphorylationEERAKADTLKLPPTF
HHHHHCCCCCCCCCE
30.5625619855
2569PhosphorylationDTLKLPPTFFCGVCS
CCCCCCCCEEECCCC
27.6625619855
2576PhosphorylationTFFCGVCSDTDEDNG
CEEECCCCCCCCCCC
40.9327087446
2578PhosphorylationFCGVCSDTDEDNGNG
EECCCCCCCCCCCCC
25.6227087446
2590PhosphorylationGNGEDFQSELRKVCE
CCCHHHHHHHHHHHH
38.2926643407
2627SumoylationVTNPVGCKSEEPDSD
ECCCCCCCCCCCCCC
55.7828289178
2628PhosphorylationTNPVGCKSEEPDSDT
CCCCCCCCCCCCCCC
51.7925777480
2633PhosphorylationCKSEEPDSDTKHSSS
CCCCCCCCCCCCCCC
58.8725777480
2635PhosphorylationSEEPDSDTKHSSSSP
CCCCCCCCCCCCCCC
34.3125777480
2636SumoylationEEPDSDTKHSSSSPV
CCCCCCCCCCCCCCC
46.6228289178
2638PhosphorylationPDSDTKHSSSSPVSG
CCCCCCCCCCCCCCC
33.2127742792
2639PhosphorylationDSDTKHSSSSPVSGT
CCCCCCCCCCCCCCC
34.2627742792
2640PhosphorylationSDTKHSSSSPVSGTM
CCCCCCCCCCCCCCC
41.5027742792
2641PhosphorylationDTKHSSSSPVSGTMD
CCCCCCCCCCCCCCC
31.1326824392
2644PhosphorylationHSSSSPVSGTMDKPV
CCCCCCCCCCCCCCC
31.7527742792
2646PhosphorylationSSSPVSGTMDKPVDL
CCCCCCCCCCCCCCC
18.0727742792
2654PhosphorylationMDKPVDLSTRKETDM
CCCCCCCCCCCCCCC
23.0025619855
2655PhosphorylationDKPVDLSTRKETDME
CCCCCCCCCCCCCCC
53.7225619855
2678PhosphorylationPVLFGFGSGTGLSFA
CEEEEECCCCCCCHH
30.8123984901
2680PhosphorylationLFGFGSGTGLSFADL
EEEECCCCCCCHHHH
36.3226643407
2683PhosphorylationFGSGTGLSFADLASS
ECCCCCCCHHHHHCC
21.5223984901
2729PhosphorylationGGEDEDGSDEDVVHN
CCCCCCCCCCCCCCC
50.5827087446
2746PhosphorylationIHFEPIVSLPEVEVK
CCEECCCCCCEEEEC
38.64-
2754PhosphorylationLPEVEVKSGEEDEEV
CCEEEECCCCCCHHH
57.5226525534
2788UbiquitinationERGIGDIKILWHTMK
HCCCHHHHHHHHHHH
36.1622790023
2811GlutathionylationRDQVFKVCANHVITK
CHHHHHHHHHHHHHH
3.0224333276
2835PhosphorylationSNNALVWTASDYADG
CCCEEEEEEEHHCCC
14.5921454597
2837PhosphorylationNALVWTASDYADGEA
CEEEEEEEHHCCCCH
24.6321454597
3033PhosphorylationDTVRKIESFGSPKGS
HHHHHHHHCCCCCCC
38.0828066266
3036PhosphorylationRKIESFGSPKGSVSR
HHHHHCCCCCCCCCC
22.7927600695

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
2505SPhosphorylationKinaseMAPK14P47811
GPS
-KUbiquitinationE3 ubiquitin ligasePrknQ9WVS6
PMID:22199232

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RBP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RBP2_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SUMO1_HUMANSUMO1physical
20360068
BICD2_HUMANBICD2physical
20360068
IMA1_HUMANKPNA2physical
20360068
UBC9_HUMANUBE2Iphysical
20360068
NXF1_HUMANNXF1physical
20360068
RGPD1_HUMANRGPD1physical
20360068
RGPD2_HUMANRGPD2physical
20360068
IMA3_HUMANKPNA4physical
20360068
NUSAP_HUMANNUSAP1physical
20360068
NUMA1_HUMANNUMA1physical
20360068
RAGP1_HUMANRANGAP1physical
20360068
IMB1_HUMANKPNB1physical
20360068
RANG_HUMANRANBP1physical
20360068
RBP2_HUMANRANBP2physical
20360068
IMA4_HUMANKPNA3physical
20360068
RGPD5_HUMANRGPD5physical
20360068
RAN_HUMANRANphysical
20360068
XIAP_HUMANXIAPphysical
26496610
RCC1_HUMANRCC1physical
26496610
GLE1_HUMANGLE1physical
26496610
HSP7C_HUMANHSPA8physical
26496610
IMB1_HUMANKPNB1physical
26496610
IMA4_HUMANKPNA3physical
26496610
IMA3_HUMANKPNA4physical
26496610
LAMB3_HUMANLAMB3physical
26496610
NUP88_HUMANNUP88physical
26496610
NUP98_HUMANNUP98physical
26496610
CHM1A_HUMANCHMP1Aphysical
26496610
PP1G_HUMANPPP1CCphysical
26496610
RAN_HUMANRANphysical
26496610
RAGP1_HUMANRANGAP1physical
26496610
TRI27_HUMANTRIM27physical
26496610
SEC13_HUMANSEC13physical
26496610
HLTF_HUMANHLTFphysical
26496610
SUMO2_HUMANSUMO2physical
26496610
UBC9_HUMANUBE2Iphysical
26496610
SUMO1_HUMANSUMO1physical
26496610
NU214_HUMANNUP214physical
26496610
AAAS_HUMANAAASphysical
26496610
RAE1L_HUMANRAE1physical
26496610
NU155_HUMANNUP155physical
26496610
NUP93_HUMANNUP93physical
26496610
TELO2_HUMANTELO2physical
26496610
NU153_HUMANNUP153physical
26496610
PDC6I_HUMANPDCD6IPphysical
26496610
ANM3_HUMANPRMT3physical
26496610
NXF1_HUMANNXF1physical
26496610
IPO7_HUMANIPO7physical
26496610
NUP50_HUMANNUP50physical
26496610
NUPL2_HUMANNUPL2physical
26496610
ERLN2_HUMANERLIN2physical
26496610
NU205_HUMANNUP205physical
26496610
NU160_HUMANNUP160physical
26496610
NEMP1_HUMANTMEM194Aphysical
26496610
UBR4_HUMANUBR4physical
26496610
NU188_HUMANNUP188physical
26496610
NUP62_HUMANNUP62physical
26496610
NARF_HUMANNARFphysical
26496610
CHM2A_HUMANCHMP2Aphysical
26496610
MOG1_HUMANRANGRFphysical
26496610
NXT1_HUMANNXT1physical
26496610
SENP1_HUMANSENP1physical
26496610
TM214_HUMANTMEM214physical
26496610
HEAT3_HUMANHEATR3physical
26496610
NDC1_HUMANNDC1physical
26496610
NU133_HUMANNUP133physical
26496610
NXT2_HUMANNXT2physical
26496610
CCD47_HUMANCCDC47physical
26496610
NU107_HUMANNUP107physical
26496610
Z512B_HUMANZNF512Bphysical
26496610
SENP2_HUMANSENP2physical
26496610
NUP37_HUMANNUP37physical
26496610
NUP85_HUMANNUP85physical
26496610
ACTL8_HUMANACTL8physical
26496610
SEH1_HUMANSEH1Lphysical
26496610
RGPD5_HUMANRGPD5physical
26496610
TM209_HUMANTMEM209physical
26496610
SFXN1_HUMANSFXN1physical
26496610
CHM4B_HUMANCHMP4Bphysical
26496610
NUP53_HUMANNUP35physical
26496610
CDCA2_HUMANCDCA2physical
26496610
S35B2_HUMANSLC35B2physical
26496610
NUP43_HUMANNUP43physical
26496610
RGPD8_HUMANRGPD8physical
26496610

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RBP2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-781; SER-788 ANDSER-2505, AND MASS SPECTROMETRY.
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-954 AND SER-2729, ANDMASS SPECTROMETRY.
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2505 AND SER-2729, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1098; SER-2083;SER-2088; SER-2113; SER-2117; THR-2130; SER-2134; SER-2576 ANDTHR-2578, AND MASS SPECTROMETRY.
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2505, AND MASSSPECTROMETRY.

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