SGPL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SGPL1_MOUSE
• UniProt AC: Q8R0X7
• Protein Name: Sphingosine-1-phosphate lyase 1 {ECO:0000305}
• Gene Name: Sgpl1 {ECO:0000312|MGI:MGI:1261415}
• Organism: Mus musculus (Mouse).
• Sequence Length: 568
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type III membrane protein .
• Protein Description: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis..
• Protein Sequence: MPGTDLLKLKDFEPYLEILESYSTKAKNYVNGYCTKYEPWQLIAWSVLCTLLIVWVYELIFQPESLWSRFKKKLFKLIRKMPFIGRKIEQQVSKAKKDLVKNMPFLKVDKDYVKTLPAQGMGTAEVLERLKEYSSMDGSWQEGKASGAVYNGEPKLTELLVQAYGEFTWSNPLHPDIFPGLRKLEAEIVRMTCSLFNGGPDSCGCVTSGGTESILMACKAYRDLALEKGIKTPEIVAPESAHAAFDKAAHYFGMKIVRVALKKNMEVDVQAMKRAISRNTAMLVCSTPQFPHGVMDPVPEVAKLAVRYKIPLHVDACLGGFLIVFMEKAGYPLEKPFDFRVKGVTSISADTHKYGYAPKGSSVVMYSNEKYRTYQFFVGADWQGGVYASPSIAGSRPGGIIAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKNIFIFGDPQLSVIALGSNDFDIYRLSNMMSAKGWNFNYLQFPRSIHFCITLVHTRKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQATIDRKLVAEISSVFLDCLYTTDPVTQGNQMNGSPKPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
101	Malonylation	KAKKDLVKNMPFLKV HHHHHHHHCCCEEEE	55.62	26320211
107	Acetylation	VKNMPFLKVDKDYVK HHCCCEEEECHHHHH	49.09	22902405
107	Ubiquitination	VKNMPFLKVDKDYVK HHCCCEEEECHHHHH	49.09	-
131	Ubiquitination	AEVLERLKEYSSMDG HHHHHHHHHHHCCCC	61.91	27667366
232	Phosphorylation	ALEKGIKTPEIVAPE HHHCCCCCCCCCCCH	25.00	22942356
353	Acetylation	SISADTHKYGYAPKG EEECCCCCCEECCCC	42.32	22826441
353	N6-(pyridoxal phosphate)lysine	SISADTHKYGYAPKG EEECCCCCCEECCCC	42.32	-
353	Ubiquitination	SISADTHKYGYAPKG EEECCCCCCEECCCC	42.32	-
353	Other	SISADTHKYGYAPKG EEECCCCCCEECCCC	42.32	-
356	Nitrated tyrosine	ADTHKYGYAPKGSSV CCCCCCEECCCCCEE	19.35	-
356	Nitration	ADTHKYGYAPKGSSV CCCCCCEECCCCCEE	19.35	-
366	Nitrated tyrosine	KGSSVVMYSNEKYRT CCCEEEEECCCCEEE	9.20	-
366	Nitration	KGSSVVMYSNEKYRT CCCEEEEECCCCEEE	9.20	-
370	Acetylation	VVMYSNEKYRTYQFF EEEECCCCEEEEEEE	44.26	23954790
438	Ubiquitination	KSELENIKNIFIFGD HHHHHHCCEEEEECC	56.42	-
502	Acetylation	RVAIQFLKDIRESVT HHHHHHHHHHHHHHH	53.01	23236377
513	Malonylation	ESVTQIMKNPKAKTT HHHHHHHHCCCCCCC	72.26	32601280
532	Phosphorylation	IYGMAQATIDRKLVA HHHHHHHHCCHHHHH	16.01	20531401
542	Phosphorylation	RKLVAEISSVFLDCL HHHHHHHHHHHHHHH	16.38	25367039
543	Phosphorylation	KLVAEISSVFLDCLY HHHHHHHHHHHHHHC	23.66	25367039
550	Phosphorylation	SVFLDCLYTTDPVTQ HHHHHHHCCCCCCCC	17.58	23984901
551	Phosphorylation	VFLDCLYTTDPVTQG HHHHHHCCCCCCCCC	16.27	23984901
552	Phosphorylation	FLDCLYTTDPVTQGN HHHHHCCCCCCCCCC	25.42	23984901
556	Phosphorylation	LYTTDPVTQGNQMNG HCCCCCCCCCCCCCC	35.83	26745281
564	Phosphorylation	QGNQMNGSPKPR--- CCCCCCCCCCCC---	25.42	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SGPL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SGPL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SGPL1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SGPL1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.