IMA7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IMA7_MOUSE
• UniProt AC: O35345
• Protein Name: Importin subunit alpha-7
• Gene Name: Kpna6
• Organism: Mus musculus (Mouse).
• Sequence Length: 536
• Subcellular Localization: Cytoplasm.
• Protein Description: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus..
• Protein Sequence: METMASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEAAMFDSLLMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVINTPGVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSLCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSSKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLAPQVDETQQQFIFQQPEAPMEGFQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------METMASPG -------CCCCCCCC	9.74	-
1	Oxidation	-------METMASPG -------CCCCCCCC	9.74	17242355
3	Phosphorylation	-----METMASPGKD -----CCCCCCCCCC	19.42	25619855
4	Oxidation	----METMASPGKDN ----CCCCCCCCCCC	1.90	17242355
6	Phosphorylation	--METMASPGKDNYR --CCCCCCCCCCCCC	24.30	23527152
12	Phosphorylation	ASPGKDNYRMKSYKN CCCCCCCCCCHHHCC	23.40	25619855
113	Phosphorylation	KLLSKEPSPPIDEVI HHHCCCCCCCHHHHH	44.38	27180971
134	Ubiquitination	DRFVEFLKRNENCTL HHHHHHHHHCCCCEE	59.50	-
359	Phosphorylation	IRKEACWTISNITAG HHHHHCEEECCCCCC	17.89	25159016
361	Phosphorylation	KEACWTISNITAGNR HHHCEEECCCCCCCH	18.14	25159016
364	Phosphorylation	CWTISNITAGNRAQI CEEECCCCCCCHHHH	32.53	25159016
431	Phosphorylation	KPLCDLLTVMDSKIV HHHHHHHHHCCHHHH	22.53	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IMA7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IMA7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IMA7_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IMA7_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, AND MASSSPECTROMETRY.
PubMed: 17242355