PLOD1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLOD1_MOUSE
• UniProt AC: Q9R0E2
• Protein Name: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
• Gene Name: Plod1
• Organism: Mus musculus (Mouse).
• Sequence Length: 728
• Subcellular Localization: Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
• Protein Description: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. [PubMed: 27119146 Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (By similarity These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links]
• Protein Sequence: MRSLLLLAPLAWLLLVQAKDDAKLEDNLLVLTVATKETEGFRRFKRSAQFFNYKIQSLGLGEDWSVDGGPAAAGGGQKVRLLKKALEKHADKEDLVILFVDSYDVVFASGPRELLKKFQQAKSQVVFSAEEHIYPDRRLEAKYPTVPDGKRFLGSGGFIGYAPSLSKLVAEWEGQDSDSDQLFYTKIFLNPEKREQINISLDHRCRIFQNLDGALDEVVLKFEMGHVRARNLAYDTLPVVVHGNGPTKLQLNYLGNYIPRFWTFETGCTVCDEGLRSLKGIGDEALPTVLVGVFIEQPTPFLSLFFLRLLRLRYPQKQMRLFIHNQERHHKLQVEQFLAEHGSEYQSVKLVGPEVRMANADARNMGADLCRQDQTCTYYFSVDADVALTEPNSLRLLIEQNKNVIAPLMTRHGRLWSNFWGGLSADGYYARSEDYVDIVQGRRVGVWNVPYISNIYLIKGSALRAELQNVDLFHYSKLDSDMSFCANVRQQEVFMFLTNRHTFGHLLSLDNYQTTHLHNDLWEVFSNPEDWKEKYIHENYTKALAGKLVETPCPDVYWFPIFTEAACDELVEEMEHYGQWSLGDNKDNRIQGGYENVPTIDIHMNQITFEREWHKFLVEYIAPMTEKLYPGYYTRAQFDLAFVVRYKPDEQPSLMPHHDASTFTVNIALNRVGEDYEGGGCRFLRYNCSVRAPRKGWALLHPGRLTHYHEGLPTTKGTRYIAVSFVDP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
177	Phosphorylation	AEWEGQDSDSDQLFY HHHCCCCCCHHCEEE	31.00	26525534
179	Phosphorylation	WEGQDSDSDQLFYTK HCCCCCCHHCEEEEE	31.07	26525534
198	N-linked_Glycosylation	PEKREQINISLDHRC HHHHHHCEECHHHHH	19.93	19349973
402	Acetylation	RLLIEQNKNVIAPLM HHHHHCCCCCHHHHH	52.89	22826441
539	N-linked_Glycosylation	KEKYIHENYTKALAG HHHHHCHHHHHHHCC	35.29	-
687	N-linked_Glycosylation	GCRFLRYNCSVRAPR CEEEEEEEEEECCCC	12.73	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLOD1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLOD1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLOD1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PLOD1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-198, AND MASSSPECTROMETRY.
PubMed: 19349973