HXK2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXK2_MOUSE
• UniProt AC: O08528
• Protein Name: Hexokinase-2
• Gene Name: Hk2
• Organism: Mus musculus (Mouse).
• Sequence Length: 917
• Protein Sequence: MIASHMIACLFTELNQNQVQKVDQYLYHMRLSDETLLEISRRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQRVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVDLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDQNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDGTLNDIRTEFDREIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKAELLFQGKLSPELLTTGSFETKDVSDIEDDKDGIQKAYQILVRLGLSPLQEDCVATHRICQIVSTRSASLCAATLAAVLWRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKAVRRLVPDCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLESLKLSHEQLLEVKRRMKVEMEQGLSKETHEAAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKRRGVEMHNKIYSIPQEVMHGTGEELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDQSILLKWTKGFKASGCEGEDVVTLLKEAIRRREEFDLDVVAVVNDTVGTMMTCGYEDPHCEVGLIVGTGSNACYMEEMRNVELVDGEEGRMCVNMEWGAFGDNGCLDDLRTVFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILRHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDKIRENRGLDNLKVTVGVDGTLYKLHPHFAKVMHETVRDLAPKCDVSFLESEDGSGKGAALITAVACRIREAGQR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MIASHMIA -------CHHHHHHH	5.36	-
27	Phosphorylation	QKVDQYLYHMRLSDE HHHHHHHHHCCCCHH	6.66	22345495
35	Phosphorylation	HMRLSDETLLEISRR HCCCCHHHHHHHHHH	41.45	30482847
40	Phosphorylation	DETLLEISRRFRKEM HHHHHHHHHHHHHHH	14.18	30482847
122	Phosphorylation	PEDIMRGSGTQLFDH CHHHHCCCCCHHHHH	28.44	-
155	Phosphorylation	LPLGFTFSFPCHQTK CCCCEEEEEECCCCC	25.81	26060331
340	Phosphorylation	SFETKDVSDIEDDKD CCCCCCHHHCCCCCC	42.90	26525534
368	S-nitrosocysteine	LSPLQEDCVATHRIC CCCCCCHHHHHHHHH	1.90	-
368	S-nitrosylation	LSPLQEDCVATHRIC CCCCCCHHHHHHHHH	1.90	21278135
375	S-nitrosylation	CVATHRICQIVSTRS HHHHHHHHHHHCCCC	1.97	21278135
375	Glutathionylation	CVATHRICQIVSTRS HHHHHHHHHHHCCCC	1.97	24333276
375	S-nitrosocysteine	CVATHRICQIVSTRS HHHHHHHHHHHCCCC	1.97	-
386	S-nitrosylation	STRSASLCAATLAAV CCCCHHHHHHHHHHH	1.93	21278135
386	S-nitrosocysteine	STRSASLCAATLAAV CCCCHHHHHHHHHHH	1.93	-
415	Phosphorylation	STIGVDGSVYKKHPH HHCCCCCCHHHHCHH	20.15	23684622
438	Glutathionylation	VRRLVPDCDVRFLRS HHHHCCCCCEEEEEC	4.22	24333276
438	S-nitrosylation	VRRLVPDCDVRFLRS HHHHCCCCCEEEEEC	4.22	21278135
438	S-nitrosocysteine	VRRLVPDCDVRFLRS HHHHCCCCCEEEEEC	4.22	-
451	Ubiquitination	RSEDGSGKGAAMVTA ECCCCCCHHHHHHHH	47.26	22790023
457	Phosphorylation	GKGAAMVTAVAYRLA CHHHHHHHHHHHHHH	11.43	-
461	Phosphorylation	AMVTAVAYRLADQHR HHHHHHHHHHHHHHH	10.28	22817900
473	Phosphorylation	QHRARQKTLESLKLS HHHHHHHHHHHCCCC	27.67	-
488	Ubiquitination	HEQLLEVKRRMKVEM HHHHHHHHHHHHHHH	25.55	22790023
517	S-nitrosylation	KMLPTYVCATPDGTE CEECEEEEECCCCCC	2.16	21278135
517	S-nitrosocysteine	KMLPTYVCATPDGTE CEECEEEEECCCCCC	2.16	-
519	Phosphorylation	LPTYVCATPDGTEKG ECEEEEECCCCCCCC	19.45	28066266
523	Phosphorylation	VCATPDGTEKGDFLA EEECCCCCCCCCEEE	41.73	28066266
606	S-nitrosocysteine	GFTFSFPCQQNSLDQ EEEEEEECCCCCCCH	6.48	-
606	S-nitrosylation	GFTFSFPCQQNSLDQ EEEEEEECCCCCCCH	6.48	21278135
628	S-nitrosocysteine	KGFKASGCEGEDVVT CCCHHCCCCCCHHHH	5.86	-
628	S-nitrosylation	KGFKASGCEGEDVVT CCCHHCCCCCCHHHH	5.86	21278135
738	Ubiquitination	ELSLNPGKQRFEKMI HHCCCCCHHHHHHHH	39.29	22790023
763	Ubiquitination	NILIDFTKRGLLFRG HHHHHHHHCCEECCC	44.45	22790023
794	S-nitrosocysteine	LSQIESDCLALLQVR HHHHHHHHHHHHHHH	3.14	-
794	S-nitrosylation	LSQIESDCLALLQVR HHHHHHHHHHHHHHH	3.14	21278135
813	S-nitrosocysteine	HLGLESTCDDSIIVK HCCCCCCCCCCCHHH	8.34	-
813	S-nitrosylation	HLGLESTCDDSIIVK HCCCCCCCCCCCHHH	8.34	21278135
834	S-nitrosocysteine	ARRAAQLCGAGMAAV HHHHHHHHCCCHHHH	2.03	-
834	S-nitrosylation	ARRAAQLCGAGMAAV HHHHHHHHCCCHHHH	2.03	21278135
885	Ubiquitination	TVRDLAPKCDVSFLE HHHHHCCCCCEEEEE	37.14	-
899	Ubiquitination	ESEDGSGKGAALITA ECCCCCCHHHHHHHH	47.26	-
909	S-nitrosylation	ALITAVACRIREAGQ HHHHHHHHHHHHHCC	2.74	21278135
909	S-nitrosocysteine	ALITAVACRIREAGQ HHHHHHHHHHHHHCC	2.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
473	T	Phosphorylation	Kinase	AKT1	P31749	PSP
473	T	Phosphorylation	Kinase	AKT2	P31751	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXK2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXK2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HXK2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-461, AND MASSSPECTROMETRY.
PubMed: 18034455