| UniProt ID | PICAL_MOUSE | |
|---|---|---|
| UniProt AC | Q7M6Y3 | |
| Protein Name | Phosphatidylinositol-binding clathrin assembly protein | |
| Gene Name | Picalm | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 660 | |
| Subcellular Localization | Membrane, clathrin-coated pit . Golgi apparatus . Cytoplasmic vesicle, clathrin-coated vesicle . Nucleus . Colocalized with clathrin in the Golgi area. Interaction with PIMREG may target PICALM to the nucleus in some cells. | |
| Protein Description | Assembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Plays a crucial role in fetal and adult hematopoiesis, and normal prenatal and postnatal growth and viability.. | |
| Protein Sequence | MSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHAMSAAPQGASTWGDPFSATLDAVEDAIPSLNPFLTKSSGDVHLPIASDVSTFTTRTPTHEMFVGFSPSPVAQPHSSAGLNVDFESVFGNKSTNVAVDSGGFDELGGLLKPTVASQNQSLPVAKLPPNKLVSDDLDSSLANLVGNLGIGNGTTKNDVSWSQPGEKKLTGGSNWQPKVAPTTAWSAATMNGMHFPQYAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQIQFM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSGQSLTDR ------CCCCCHHHH | - | ||
| 2 | Phosphorylation | ------MSGQSLTDR ------CCCCCHHHH | 27841257 | ||
| 5 | Phosphorylation | ---MSGQSLTDRITA ---CCCCCHHHHHHH | 21183079 | ||
| 7 | Phosphorylation | -MSGQSLTDRITAAQ -CCCCCHHHHHHHHH | 23984901 | ||
| 11 | Phosphorylation | QSLTDRITAAQHSVT CCHHHHHHHHHHCCC | 23984901 | ||
| 16 | Phosphorylation | RITAAQHSVTGSAVS HHHHHHHCCCCCHHC | 30352176 | ||
| 18 | Phosphorylation | TAAQHSVTGSAVSKT HHHHHCCCCCHHCHH | 29176673 | ||
| 20 | Phosphorylation | AQHSVTGSAVSKTVC HHHCCCCCHHCHHHH | 29472430 | ||
| 23 | Phosphorylation | SVTGSAVSKTVCKAT CCCCCHHCHHHHHHH | 29472430 | ||
| 24 | Ubiquitination | VTGSAVSKTVCKATT CCCCHHCHHHHHHHH | - | ||
| 28 | Malonylation | AVSKTVCKATTHEIM HHCHHHHHHHHCHHH | 26320211 | ||
| 96 | Phosphorylation | GNERFIQYLASRNTL CCHHHHHHHHHCCCH | - | ||
| 99 | Phosphorylation | RFIQYLASRNTLFNL HHHHHHHHCCCHHHH | - | ||
| 102 | Phosphorylation | QYLASRNTLFNLSNF HHHHHCCCHHHHHHH | 22817900 | ||
| 107 | Phosphorylation | RNTLFNLSNFLDKSG CCCHHHHHHHHCCCC | 22324799 | ||
| 134 | Ubiquitination | YSRYLNEKAVSYRQV HHHHHCHHCCCHHEE | - | ||
| 158 | Phosphorylation | GADGVMRTMNTEKLL CCCCCHHCCCHHHHH | 20531401 | ||
| 163 | Ubiquitination | MRTMNTEKLLKTVPI HHCCCHHHHHHHCHH | - | ||
| 252 | Ubiquitination | TRISEFLKVAEQVGI HHHHHHHHHHHHHCC | - | ||
| 293 | Phosphorylation | EGKKIKDSTAASRAT CCCCCCCCHHHHHHH | 22871156 | ||
| 300 | Phosphorylation | STAASRATTLSNAVS CHHHHHHHHHHHHHH | 25266776 | ||
| 301 | Phosphorylation | TAASRATTLSNAVSS HHHHHHHHHHHHHHH | 25266776 | ||
| 303 | Phosphorylation | ASRATTLSNAVSSLA HHHHHHHHHHHHHHH | 30352176 | ||
| 307 | Phosphorylation | TTLSNAVSSLASTGL HHHHHHHHHHHHCCC | 30352176 | ||
| 308 | Phosphorylation | TLSNAVSSLASTGLS HHHHHHHHHHHCCCC | 25266776 | ||
| 311 | Phosphorylation | NAVSSLASTGLSLTK HHHHHHHHCCCCCCC | 30352176 | ||
| 312 | Phosphorylation | AVSSLASTGLSLTKV HHHHHHHCCCCCCCC | 25266776 | ||
| 315 | Phosphorylation | SLASTGLSLTKVDER HHHHCCCCCCCCCHH | 30352176 | ||
| 317 | Phosphorylation | ASTGLSLTKVDEREK HHCCCCCCCCCHHHH | 29472430 | ||
| 318 | Ubiquitination | STGLSLTKVDEREKQ HCCCCCCCCCHHHHH | - | ||
| 324 | Ubiquitination | TKVDEREKQAALEEE CCCCHHHHHHHHHHH | - | ||
| 352 | Phosphorylation | ELAKKPHTSLTTAAS HHHCCCCCCCCCCCC | 26643407 | ||
| 353 | Phosphorylation | LAKKPHTSLTTAASP HHCCCCCCCCCCCCC | 26643407 | ||
| 355 | O-linked_Glycosylation | KKPHTSLTTAASPVS CCCCCCCCCCCCCCC | 30059200 | ||
| 355 | Phosphorylation | KKPHTSLTTAASPVS CCCCCCCCCCCCCCC | 26643407 | ||
| 356 | Phosphorylation | KPHTSLTTAASPVST CCCCCCCCCCCCCCC | 26643407 | ||
| 356 | O-linked_Glycosylation | KPHTSLTTAASPVST CCCCCCCCCCCCCCC | 30059200 | ||
| 359 | Phosphorylation | TSLTTAASPVSTSAG CCCCCCCCCCCCCCC | 26643407 | ||
| 362 | Phosphorylation | TTAASPVSTSAGGIM CCCCCCCCCCCCCCC | 26643407 | ||
| 363 | Phosphorylation | TAASPVSTSAGGIMT CCCCCCCCCCCCCCC | 26643407 | ||
| 364 | Phosphorylation | AASPVSTSAGGIMTA CCCCCCCCCCCCCCC | 26643407 | ||
| 370 | Phosphorylation | TSAGGIMTAPAIDIF CCCCCCCCCCEEEEE | 26643407 | ||
| 443 | Phosphorylation | LNPFLTKSSGDVHLP CCCCCCCCCCCEECC | 26824392 | ||
| 444 | Phosphorylation | NPFLTKSSGDVHLPI CCCCCCCCCCEECCC | 25266776 | ||
| 453 | Phosphorylation | DVHLPIASDVSTFTT CEECCCCCCCCCEEC | 23984901 | ||
| 453 | O-linked_Glycosylation | DVHLPIASDVSTFTT CEECCCCCCCCCEEC | 30059200 | ||
| 456 | Phosphorylation | LPIASDVSTFTTRTP CCCCCCCCCEECCCC | 29514104 | ||
| 460 (in isoform 2) | Ubiquitination | - | - | ||
| 460 (in isoform 2) | Acetylation | - | - | ||
| 469 (in isoform 3) | Phosphorylation | - | 25521595 | ||
| 469 (in isoform 2) | Phosphorylation | - | 25521595 | ||
| 472 | Phosphorylation | HEMFVGFSPSPVAQP CCCCCCCCCCCCCCC | 26824392 | ||
| 474 | Phosphorylation | MFVGFSPSPVAQPHS CCCCCCCCCCCCCCC | 23984901 | ||
| 481 | Phosphorylation | SPVAQPHSSAGLNVD CCCCCCCCCCCCCCC | 23984901 | ||
| 482 | Phosphorylation | PVAQPHSSAGLNVDF CCCCCCCCCCCCCCH | 23984901 | ||
| 491 | Phosphorylation | GLNVDFESVFGNKST CCCCCHHHHHCCCCC | 23984901 | ||
| 519 (in isoform 5) | Phosphorylation | - | 25521595 | ||
| 520 | Phosphorylation | LLKPTVASQNQSLPV CCCCCCCCCCCCCCC | 29472430 | ||
| 524 | Phosphorylation | TVASQNQSLPVAKLP CCCCCCCCCCCCCCC | 30352176 | ||
| 534 | Ubiquitination | VAKLPPNKLVSDDLD CCCCCCCCCCCCCCC | - | ||
| 570 | Ubiquitination | SWSQPGEKKLTGGSN CCCCCCCEECCCCCC | - | ||
| 573 | Phosphorylation | QPGEKKLTGGSNWQP CCCCEECCCCCCCCC | 29550500 | ||
| 576 | Phosphorylation | EKKLTGGSNWQPKVA CEECCCCCCCCCCCC | 29472430 | ||
| 601 | Phosphorylation | NGMHFPQYAPPVMAY CCCCCCCCCCCEEEC | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PICAL_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PICAL_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PICAL_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PICAL_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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