PDLI1_MOUSE - dbPTM
PDLI1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PDLI1_MOUSE
UniProt AC O70400
Protein Name PDZ and LIM domain protein 1
Gene Name Pdlim1
Organism Mus musculus (Mouse).
Sequence Length 327
Subcellular Localization Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, Z line . Associates with the actin stress fibers (PubMed:11596114).
Protein Description Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (By similarity). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity)..
Protein Sequence MTTQQIVLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAAIANLCIGDLITAIDGEDTSSMTHLEAQNKIKGCADNMTLTVSRSEQKIWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAHNRSAMPFTASPAPSTRVITNQYNSPTGLYSSENISNFNNAVESKTSASGEEANSRPVVQPHPSGSLIIDKDSEVYKMLQEKQELNEPPKQSTSFLVLQEILESDGKGDPNKPSGFRSVKAPVTKVAASVGNAQKLPICDKCGTGIVGVFVKLRDHHRHPECYVCTDCGINLKQKGHFFVEDQIYCEKHARERVTPPEGYDVVTVFRE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MTTQQIVLQ
------CCCEEEEEC		33.06-
2Phosphorylation------MTTQQIVLQ
------CCCEEEEEC		33.0626643407
3Phosphorylation-----MTTQQIVLQG
-----CCCEEEEECC		19.7126643407
22AcetylationGFRLVGGKDFEQPLA
CEEEECCCCCCCCEE		54.0023806337
34PhosphorylationPLAISRVTPGSKAAI
CEEEEEECCCCHHHH		22.33-
71MalonylationLEAQNKIKGCADNMT
HHHHHHHCCCCCCCE		49.9326320211
71AcetylationLEAQNKIKGCADNMT
HHHHHHHCCCCCCCE		49.9322826441
90PhosphorylationRSEQKIWSPLVTEEG
HHHCEECCCEECCCC		16.3026824392
102PhosphorylationEEGKRHPYKMNLASE
CCCCCCCCCCCCCCC		19.4229514104
108PhosphorylationPYKMNLASEPQEVLH
CCCCCCCCCCCEEEE		53.6428285833
118PhosphorylationQEVLHIGSAHNRSAM
CEEEECCCCCCCCCC		26.2526824392
123PhosphorylationIGSAHNRSAMPFTAS
CCCCCCCCCCCCCCC		33.9523527152
128PhosphorylationNRSAMPFTASPAPST
CCCCCCCCCCCCCCC		21.9825263469
128O-linked_GlycosylationNRSAMPFTASPAPST
CCCCCCCCCCCCCCC		21.9830059200
130PhosphorylationSAMPFTASPAPSTRV
CCCCCCCCCCCCCEE		20.6627087446
134PhosphorylationFTASPAPSTRVITNQ
CCCCCCCCCEEEECC		30.8323737553
135PhosphorylationTASPAPSTRVITNQY
CCCCCCCCEEEECCC		28.0923737553
135O-linked_GlycosylationTASPAPSTRVITNQY
CCCCCCCCEEEECCC		28.0930059200
139PhosphorylationAPSTRVITNQYNSPT
CCCCEEEECCCCCCC		17.2624068923
142PhosphorylationTRVITNQYNSPTGLY
CEEEECCCCCCCCCC		21.4826745281
144PhosphorylationVITNQYNSPTGLYSS
EEECCCCCCCCCCCC		20.9227087446
146PhosphorylationTNQYNSPTGLYSSEN
ECCCCCCCCCCCCCC		39.3725521595
149PhosphorylationYNSPTGLYSSENISN
CCCCCCCCCCCCCCC		16.1125168779
150PhosphorylationNSPTGLYSSENISNF
CCCCCCCCCCCCCCC		35.9026745281
151PhosphorylationSPTGLYSSENISNFN
CCCCCCCCCCCCCCC		22.5523737553
155PhosphorylationLYSSENISNFNNAVE
CCCCCCCCCCCHHHH		47.1225777480
165PhosphorylationNNAVESKTSASGEEA
CHHHHCCCCCCCCCH		38.5123984901
166PhosphorylationNAVESKTSASGEEAN
HHHHCCCCCCCCCHH		24.9523984901
168PhosphorylationVESKTSASGEEANSR
HHCCCCCCCCCHHCC		46.6423984901
174PhosphorylationASGEEANSRPVVQPH
CCCCCHHCCCCCCCC		45.0423984901
183PhosphorylationPVVQPHPSGSLIIDK
CCCCCCCCCCEEECC		37.6730352176
185PhosphorylationVQPHPSGSLIIDKDS
CCCCCCCCEEECCCH		22.2627600695
190AcetylationSGSLIIDKDSEVYKM
CCCEEECCCHHHHHH		53.3923236377
195PhosphorylationIDKDSEVYKMLQEKQ
ECCCHHHHHHHHHHH		6.1429514104
211PhosphorylationLNEPPKQSTSFLVLQ
HCCCCCCCHHHHHHH		31.9529472430
212PhosphorylationNEPPKQSTSFLVLQE
CCCCCCCHHHHHHHH		22.4727600695
213PhosphorylationEPPKQSTSFLVLQEI
CCCCCCHHHHHHHHH		23.1027600695
226UbiquitinationEILESDGKGDPNKPS
HHHHHCCCCCCCCCC		66.19-
237PhosphorylationNKPSGFRSVKAPVTK
CCCCCCCCCCCCCEE		26.2123684622
244UbiquitinationSVKAPVTKVAASVGN
CCCCCCEEEECCCCC		30.0627667366
244MalonylationSVKAPVTKVAASVGN
CCCCCCEEEECCCCC		30.0626320211
254UbiquitinationASVGNAQKLPICDKC
CCCCCCCCCCCCCCC		54.54-
292UbiquitinationTDCGINLKQKGHFFV
CCCCCCCEECCCEEE		45.54-
307AcetylationEDQIYCEKHARERVT
CCCEEEHHHHHHCCC		38.7222826441
314PhosphorylationKHARERVTPPEGYDV
HHHHHCCCCCCCCCE		39.0728833060
319PhosphorylationRVTPPEGYDVVTVFR
CCCCCCCCCEEEEEE		12.1429514104
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PDLI1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PDLI1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PDLI1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PDLI1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PDLI1_MOUSE

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Related Literatures of Post-Translational Modification

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