RL18_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RL18_MOUSE
• UniProt AC: P35980
• Protein Name: 60S ribosomal protein L18
• Gene Name: Rpl18
• Organism: Mus musculus (Mouse).
• Sequence Length: 188
• Subcellular Localization: Cytoplasm, cytosol . Cytoplasm . Rough endoplasmic reticulum . Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
• Protein Description: Component of the large ribosomal subunit..
• Protein Sequence: MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGRENKTAVVVGTVTDDVRILEVPKLKVCALRVSSRARSRILKAGGKILTFDQLALESPKGRGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	VRRKEPKSQDIYLRL CCCCCCCCHHHHHHH	43.74	28066266
30	Ubiquitination	IYLRLLVKLYRFLAR HHHHHHHHHHHHHHH	39.51	-
30	Acetylation	IYLRLLVKLYRFLAR HHHHHHHHHHHHHHH	39.51	23201123
49	Ubiquitination	TFNQVVLKRLFMSRT CHHHHHHHHHHHCCC	35.13	-
49	Succinylation	TFNQVVLKRLFMSRT CHHHHHHHHHHHCCC	35.13	23806337
49	Acetylation	TFNQVVLKRLFMSRT CHHHHHHHHHHHCCC	35.13	23806337
56	Phosphorylation	KRLFMSRTNRPPLSL HHHHHCCCCCCCCCH	28.42	24899341
62	Phosphorylation	RTNRPPLSLSRMIRK CCCCCCCCHHHHHHH	30.03	29176673
64	Phosphorylation	NRPPLSLSRMIRKMK CCCCCCHHHHHHHCC	19.20	29176673
78	Ubiquitination	KLPGRENKTAVVVGT CCCCCCCCEEEEEEE	32.86	22790023
97	Acetylation	VRILEVPKLKVCALR EEEEECCCCEEEEEE	67.14	23201123
101	S-palmitoylation	EVPKLKVCALRVSSR ECCCCEEEEEECCHH	2.56	28526873
101	Glutathionylation	EVPKLKVCALRVSSR ECCCCEEEEEECCHH	2.56	24333276
106	Phosphorylation	KVCALRVSSRARSRI EEEEEECCHHHHHHH	13.99	27600695
107	Phosphorylation	VCALRVSSRARSRIL EEEEECCHHHHHHHH	27.40	-
119	Ubiquitination	RILKAGGKILTFDQL HHHHHCCEEEEEEEE	33.36	22790023
119	Acetylation	RILKAGGKILTFDQL HHHHHCCEEEEEEEE	33.36	23236377
122	Phosphorylation	KAGGKILTFDQLALE HHCCEEEEEEEEECC	28.74	25777480
130	Phosphorylation	FDQLALESPKGRGTV EEEEECCCCCCCCEE	32.53	27087446
132	Ubiquitination	QLALESPKGRGTVLL EEECCCCCCCCEEEE	71.20	-
132	Acetylation	QLALESPKGRGTVLL EEECCCCCCCCEEEE	71.20	23806337
132	Succinylation	QLALESPKGRGTVLL EEECCCCCCCCEEEE	71.20	23806337
136	Phosphorylation	ESPKGRGTVLLSGPR CCCCCCCEEEECCCC	13.45	22817900
140	Phosphorylation	GRGTVLLSGPRKGRE CCCEEEECCCCCCHH	42.46	22817900
149	Phosphorylation	PRKGREVYRHFGKAP CCCCHHHHHHCCCCC	8.13	29514104
158	Phosphorylation	HFGKAPGTPHSHTKP HCCCCCCCCCCCCCH	19.44	26824392
161	Phosphorylation	KAPGTPHSHTKPYVR CCCCCCCCCCCHHCC	33.77	25159016
163	Phosphorylation	PGTPHSHTKPYVRSK CCCCCCCCCHHCCCC	36.41	28066266
166	Phosphorylation	PHSHTKPYVRSKGRK CCCCCCHHCCCCCHH	15.28	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RL18_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RL18_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RL18_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RL18_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.