C1TC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: C1TC_MOUSE
• UniProt AC: Q922D8
• Protein Name: C-1-tetrahydrofolate synthase, cytoplasmic
• Gene Name: Mthfd1
• Organism: Mus musculus (Mouse).
• Sequence Length: 935
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MAPAGILNGKLVSAQIRDRLKNQVTRMQEQVPGFTPGLAILQVGDRDDSNLYINVKLKAAEEIGIKATHIKLPRTSTESEVLKYVISLNEDASVHGFIVQLPLDSENSINTEAVINAIAPEKDVDGLTSVSAGKLARGDLNDCFIPCTPKGCLELIKEAGVQIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTANLDKEVNKGDILVVATGQPEMVKGEWIKPGAVVIDCGINYVPDDTKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAQRFLQKFKPGKWTIQYNKLNLKTPVPSDIAISRSCKPKLIGNLAREIGLLTEEVELYGETKAKVLLSALDRLKHQPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLRQNVFACVRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVPSVNGIRKFSDIQIRRLRRLGIEKTDPTTLTDDEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQSPTEKGHTRTAQFDISVASEIMAVLALTSSLEDMRERLGRMVVASSKKGEPISCEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVTEAGFGADIGMEKFFNIKCRYSGLQPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYTEEDLDLVEKGFSNLRKQIENARMFGVPVVVAVNVFKTDTDAELDLVSRLSREHGAFDAVKCTHWAEGGQGALALAQAVQRASQAPSSFQLLYDLKLSIEDKIRIIAQRIYGADDIELLPEAQNKAEIYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFVLPIRDIRASVGAGFLYPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MAPAGILN -------CCCCCCCC	10.20	-
10	Ubiquitination	PAGILNGKLVSAQIR CCCCCCCEEEHHHHH	44.64	-
10	Malonylation	PAGILNGKLVSAQIR CCCCCCCEEEHHHHH	44.64	26320211
56	Acetylation	SNLYINVKLKAAEEI CCEEEEEEEEEHHHH	39.52	23954790
58	Acetylation	LYINVKLKAAEEIGI EEEEEEEEEHHHHCC	39.57	23954790
58	Malonylation	LYINVKLKAAEEIGI EEEEEEEEEHHHHCC	39.57	26320211
79	Phosphorylation	LPRTSTESEVLKYVI CCCCCCHHHHHHHHH	32.85	28464351
128	Phosphorylation	EKDVDGLTSVSAGKL CCCCCCCCCCCCCCC	32.39	21183079
134	Ubiquitination	LTSVSAGKLARGDLN CCCCCCCCCCCCCCC	38.39	-
143	S-palmitoylation	ARGDLNDCFIPCTPK CCCCCCCCCCCCCCH	3.03	28526873
147	S-palmitoylation	LNDCFIPCTPKGCLE CCCCCCCCCCHHHHH	9.70	28526873
157	Ubiquitination	KGCLELIKEAGVQIA HHHHHHHHHHCCEEC	54.88	-
191	Phosphorylation	LLLWNNATVTTCHSK EEEECCCEEEECCCC	22.10	23140645
193	Phosphorylation	LWNNATVTTCHSKTA EECCCEEEECCCCCC	21.25	23140645
194	Phosphorylation	WNNATVTTCHSKTAN ECCCEEEECCCCCCC	12.13	23140645
195	Glutathionylation	NNATVTTCHSKTANL CCCEEEECCCCCCCC	2.20	24333276
195	S-palmitoylation	NNATVTTCHSKTANL CCCEEEECCCCCCCC	2.20	28526873
197	Phosphorylation	ATVTTCHSKTANLDK CEEEECCCCCCCCCC	33.57	25521595
204	Malonylation	SKTANLDKEVNKGDI CCCCCCCCCCCCCCE	67.72	26320211
208	Ubiquitination	NLDKEVNKGDILVVA CCCCCCCCCCEEEEE	64.24	-
246	Acetylation	NYVPDDTKPNGRKVV CCCCCCCCCCCCEEE	43.40	23201123
251	Ubiquitination	DTKPNGRKVVGDVAY CCCCCCCEEECCEEC	42.54	-
258	Phosphorylation	KVVGDVAYDEAKERA EEECCEECHHHHHHH	17.73	-
262	Ubiquitination	DVAYDEAKERASFIT CEECHHHHHHHCEEE	45.76	-
262	Acetylation	DVAYDEAKERASFIT CEECHHHHHHHCEEE	45.76	23236377
262	Malonylation	DVAYDEAKERASFIT CEECHHHHHHHCEEE	45.76	26320211
297	Acetylation	SAQRFLQKFKPGKWT HHHHHHHHHCCCCEE	58.46	23201123
299	Acetylation	QRFLQKFKPGKWTIQ HHHHHHHCCCCEEEE	60.95	23864654
302	Acetylation	LQKFKPGKWTIQYNK HHHHCCCCEEEEEEE	50.09	23864654
309	Acetylation	KWTIQYNKLNLKTPV CEEEEEEECCCCCCC	33.54	23954790
309	Malonylation	KWTIQYNKLNLKTPV CEEEEEEECCCCCCC	33.54	26320211
309	Ubiquitination	KWTIQYNKLNLKTPV CEEEEEEECCCCCCC	33.54	-
313	Ubiquitination	QYNKLNLKTPVPSDI EEEECCCCCCCCCCE	50.11	-
313	Malonylation	QYNKLNLKTPVPSDI EEEECCCCCCCCCCE	50.11	26320211
318	Phosphorylation	NLKTPVPSDIAISRS CCCCCCCCCEEECCC	41.71	-
329	Ubiquitination	ISRSCKPKLIGNLAR ECCCCCHHHHHHHHH	37.93	-
348	Phosphorylation	LTEEVELYGETKAKV CHHEEHHHCHHHHHH	10.22	29899451
351	Phosphorylation	EVELYGETKAKVLLS EEHHHCHHHHHHHHH	31.75	29899451
352	Ubiquitination	VELYGETKAKVLLSA EHHHCHHHHHHHHHH	41.74	-
354	Ubiquitination	LYGETKAKVLLSALD HHCHHHHHHHHHHHH	34.66	-
364	Acetylation	LSALDRLKHQPDGKY HHHHHHHHCCCCCCE	40.88	23201123
370	Acetylation	LKHQPDGKYVVVTGI HHCCCCCCEEEEEEC	42.10	23954790
370	Ubiquitination	LKHQPDGKYVVVTGI HHCCCCCCEEEEEEC	42.10	-
380	Phosphorylation	VVTGITPTPLGEGKS EEEECCCCCCCCCCC	23.61	23984901
387	Phosphorylation	TPLGEGKSTTTIGLV CCCCCCCCHHHHHHH	41.67	23984901
388	Phosphorylation	PLGEGKSTTTIGLVQ CCCCCCCHHHHHHHH	31.29	23984901
389	Phosphorylation	LGEGKSTTTIGLVQA CCCCCCHHHHHHHHH	24.41	23984901
390	Phosphorylation	GEGKSTTTIGLVQAL CCCCCHHHHHHHHHH	17.09	23984901
408	S-palmitoylation	LRQNVFACVRQPSQG HHHCEEEEEECCCCC	1.44	28526873
413	Phosphorylation	FACVRQPSQGPTFGI EEEEECCCCCCCCEE	39.16	29514104
417	Phosphorylation	RQPSQGPTFGIKGGA ECCCCCCCCEECCCC	41.12	22802335
473	Ubiquitination	HELTQTDKALFNRLV HHHHHHCHHHHHHHC	50.83	-
473	Malonylation	HELTQTDKALFNRLV HHHHHHCHHHHHHHC	50.83	26320211
473	Acetylation	HELTQTDKALFNRLV HHHHHHCHHHHHHHC	50.83	23236377
488	Ubiquitination	PSVNGIRKFSDIQIR CCCCCCCCCCHHHHH	47.50	-
488	Malonylation	PSVNGIRKFSDIQIR CCCCCCCCCCHHHHH	47.50	26320211
488	Acetylation	PSVNGIRKFSDIQIR CCCCCCCCCCHHHHH	47.50	22826441
490	Phosphorylation	VNGIRKFSDIQIRRL CCCCCCCCHHHHHHH	36.52	24759943
504	Ubiquitination	LRRLGIEKTDPTTLT HHHCCCCCCCCCCCC	57.20	-
511	Phosphorylation	KTDPTTLTDDEINRF CCCCCCCCHHHHHHH	39.03	26525534
543	Ubiquitination	TNDRFLRKITIGQSP CCCCCCHHEEECCCC	46.47	-
543	Malonylation	TNDRFLRKITIGQSP CCCCCCHHEEECCCC	46.47	26320211
545	Phosphorylation	DRFLRKITIGQSPTE CCCCHHEEECCCCCC	23.30	23984901
549	Phosphorylation	RKITIGQSPTEKGHT HHEEECCCCCCCCCC	28.69	25521595
551	Phosphorylation	ITIGQSPTEKGHTRT EEECCCCCCCCCCCE	56.42	22324799
553	Malonylation	IGQSPTEKGHTRTAQ ECCCCCCCCCCCEEE	59.47	26320211
553	Acetylation	IGQSPTEKGHTRTAQ ECCCCCCCCCCCEEE	59.47	23806337
553	Ubiquitination	IGQSPTEKGHTRTAQ ECCCCCCCCCCCEEE	59.47	-
595	Acetylation	RMVVASSKKGEPISC CHHHCCCCCCCCCCH	63.40	7631103
601	Phosphorylation	SKKGEPISCEDLGVS CCCCCCCCHHHCCCC	23.36	28059163
612	Phosphorylation	LGVSGALTVLMKDAI CCCCHHHHHHHHHCC	15.85	28059163
616	Acetylation	GALTVLMKDAIKPNL HHHHHHHHHCCCCCH	39.59	7631113
620	Ubiquitination	VLMKDAIKPNLMQTL HHHHHCCCCCHHHHH	29.58	-
684	Ubiquitination	MEKFFNIKCRYSGLQ HHHEEEEEECCCCCC	17.48	-
721	Ubiquitination	TAGLPLPKAYTEEDL ECCCCCCCCCCHHHH	62.80	-
733	Ubiquitination	EDLDLVEKGFSNLRK HHHHHHHHHHHHHHH	58.75	-
736	Phosphorylation	DLVEKGFSNLRKQIE HHHHHHHHHHHHHHH	43.56	29472430
784	Ubiquitination	HGAFDAVKCTHWAEG HCCCCEEECCCHHCC	34.83	-
786	Phosphorylation	AFDAVKCTHWAEGGQ CCCEEECCCHHCCCH	18.09	17203969
810	Phosphorylation	QRASQAPSSFQLLYD HHHHCCCCHHHHHHE	46.96	25195567
811	Phosphorylation	RASQAPSSFQLLYDL HHHCCCCHHHHHHEE	18.89	19060867
819	Acetylation	FQLLYDLKLSIEDKI HHHHHEECCCHHHHH	36.97	23954790
848	Ubiquitination	LLPEAQNKAEIYTKQ HCHHHHHHHEEECCC	35.00	-
854	Ubiquitination	NKAEIYTKQGFGNLP HHHEEECCCCCCCCC	31.30	-
863	S-palmitoylation	GFGNLPICMAKTHLS CCCCCCEEEEEEEEC	1.73	28526873

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of C1TC_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of C1TC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of C1TC_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of C1TC_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-786, AND MASSSPECTROMETRY.
PubMed: 17203969