| UniProt ID | TMM33_MOUSE | |
|---|---|---|
| UniProt AC | Q9CR67 | |
| Protein Name | Transmembrane protein 33 | |
| Gene Name | Tmem33 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 247 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . Melanosome . Nucleus envelope . Co-localizes with RTN4 at the ER sheets. |
|
| Protein Description | Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling.. | |
| Protein Sequence | MADTTPNGPQGAGAVQFMMTNKLDTAMWLSRLFTVYCSALFVLPLLGLHEAASFYQRALLANALTSALRLHQRLPHFQLSRAFLAQALLEDSCHYLLYSLIFVNSYPVTMSIFPVLLFSLLHAATYTKKVLDAKGSNSLPLLRSFLDKLSTNQQNILKFIACNEIFLMPATVFMLFSGQGSLLQPFIYYRFLTLRYSSRRNPYCRNLFNELRIVVEHIIMKPSCPLFVRRLCLQSIAFISRLAPTVA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MADTTPNGP ------CCCCCCCCC | 23.90 | - | |
| 134 | Ubiquitination | TKKVLDAKGSNSLPL HHHHHCCCCCCCHHH | 63.64 | 22790023 | |
| 148 | Ubiquitination | LLRSFLDKLSTNQQN HHHHHHHHHCCCHHH | 46.62 | 22790023 | |
| 221 | Ubiquitination | VVEHIIMKPSCPLFV HHHHHHCCCCCHHHH | 24.30 | - | |
| 224 | S-palmitoylation | HIIMKPSCPLFVRRL HHHCCCCCHHHHHHH | 4.62 | 28526873 | |
| 232 | S-palmitoylation | PLFVRRLCLQSIAFI HHHHHHHHHHHHHHH | 2.85 | 28526873 | |
| 235 | Phosphorylation | VRRLCLQSIAFISRL HHHHHHHHHHHHHHH | 11.70 | 21454597 | |
| 240 | Phosphorylation | LQSIAFISRLAPTVA HHHHHHHHHHCCCCC | 18.13 | 21454597 | |
| 245 | Phosphorylation | FISRLAPTVA----- HHHHHCCCCC----- | 24.37 | 21454597 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TMM33_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TMM33_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TMM33_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of TMM33_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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