dbPTM

RBM5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RBM5_MOUSE
UniProt AC	Q91YE7
Protein Name	RNA-binding protein 5
Gene Name	Rbm5
Organism	Mus musculus (Mouse).
Sequence Length	815
Subcellular Localization	Nucleus.
Protein Description	Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Caspase-2 that induces apoptosis (By similarity)..
Protein Sequence	MGSDKRVSRTERSGRYGSIIDRDDRDERESRSRRRDSDYKRSSDDRRGDRYDDYRDYDSPERERERRNSDRSEDGYHSDGDYGEHDYRHDISDERESKTIMLRGLPITITESDIREMMESFEGPQPADVRLMKRKTGVSRGFAFVEFYHLQDATSWMEANQKKLVIQGKHIAMHYSNPRPKFEDWLCNKCCLNNFRKRLKCFRCGADKFDSEQEVPPGTTESAQSVDYYCDTIILRNIAPHTVVDSIMTALSPYASLAVNNIRLIKDKQTQQNRGFAFVQLSSAMDASQLLQILQSLHPPLKIDGKTIGVDFAKSARKDLVLPDGNRVSAFSVASTAIAAAQWSSTQSQSGEGGSVDYSYMQPGQDGYTQYTQYSQDYQQFYQQQAGGLESDTSATSGTTVTTTSAAVVSQSPQLYNQTSNPPGSPTEEAQPSTSTSTQAPAASPTGVVPGTKYAVPDTSTYQYDESSGYYYDPTTGLYYDPNSQYYYNSLTQQYLYWDGEKETYVPAAEASSNQQTGLPSTKEGKEKKEKPKSKTAQQIAKDMERWAKSLNKQKENFKNSFQPVNSLREEERRESAAADAGFALFEKKGALAERQQLLPELVRNGDEENPLKRGLVAAYSGDSDNEEELVERLESEEEKLADWKKMACLLCRRQFPNRDALVRHQQLSDLHKQNMDIYRRSRLSEQELEALELREREMKYRDRAAERREKYGIPEPPEPKRKKQFDAGTVNYEQPTKDGIDHSNIGNKMLQAMGWREGSGLGRKCQGITAPIEAQVRLKGAGLGAKGSAYGLSGADSYKDAVRKAMFARFTEME

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	ERSGRYGSIIDRDDR CCCCCCCCCCCCCCC	13.87	27600695
37	Phosphorylation	SRSRRRDSDYKRSSD HHHHHCCHHCCCCCC	40.82	29899451
51	Phosphorylation	DDRRGDRYDDYRDYD CCCCCCCCCCCCCCC	20.22	25777480
54	Phosphorylation	RGDRYDDYRDYDSPE CCCCCCCCCCCCCHH	11.50	25159016
57	Phosphorylation	RYDDYRDYDSPERER CCCCCCCCCCHHHHH	14.88	25159016
59	Phosphorylation	DDYRDYDSPERERER CCCCCCCCHHHHHHH	23.56	25521595
69	Phosphorylation	RERERRNSDRSEDGY HHHHHHCCCCCCCCC	32.37	27087446
72	Phosphorylation	ERRNSDRSEDGYHSD HHHCCCCCCCCCCCC	45.06	27087446
76	Phosphorylation	SDRSEDGYHSDGDYG CCCCCCCCCCCCCCC	15.52	25619855
78	Phosphorylation	RSEDGYHSDGDYGEH CCCCCCCCCCCCCCC	34.50	25521595
82	Phosphorylation	GYHSDGDYGEHDYRH CCCCCCCCCCCCCCC	29.91	25619855
87	Phosphorylation	GDYGEHDYRHDISDE CCCCCCCCCCCCCCH	16.26	21149613
92	Phosphorylation	HDYRHDISDERESKT CCCCCCCCCHHHCCE	39.20	23684622
249	Phosphorylation	TVVDSIMTALSPYAS HHHHHHHHHHHHHHH	23.83	22802335
252	Phosphorylation	DSIMTALSPYASLAV HHHHHHHHHHHHHHH	17.25	22802335
444	Phosphorylation	STQAPAASPTGVVPG CCCCCCCCCCCCCCC	25.71	-
528	Acetylation	STKEGKEKKEKPKSK CCCCCHHCCCCCCCH	70.49	7613431
531	Acetylation	EGKEKKEKPKSKTAQ CCHHCCCCCCCHHHH	67.63	7613441
542	Acetylation	KTAQQIAKDMERWAK HHHHHHHHHHHHHHH	60.27	23806337
576	Phosphorylation	REEERRESAAADAGF CHHHHHHHHHHHHHH	22.77	28833060
620	Phosphorylation	KRGLVAAYSGDSDNE CCCCEEEECCCCCCH	11.93	26239621
621	Phosphorylation	RGLVAAYSGDSDNEE CCCEEEECCCCCCHH	31.25	25521595
623 (in isoform 2)	Phosphorylation	-	47.05	19144319
624	Phosphorylation	VAAYSGDSDNEEELV EEEECCCCCCHHHHH	45.95	27087446
636	Phosphorylation	ELVERLESEEEKLAD HHHHHHHHHHHHHHH	55.70	25159016
682	Phosphorylation	NMDIYRRSRLSEQEL CHHHHHHHCCCHHHH	28.68	28833060
685	Phosphorylation	IYRRSRLSEQELEAL HHHHHCCCHHHHHHH	35.80	28833060
787	Acetylation	KGAGLGAKGSAYGLS CCCCCCCCCCCCCCC	52.15	22826441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RBM5_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RBM5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RBM5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RBM5_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RBM5_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-624, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69 AND SER-621, AND MASSSPECTROMETRY.	17242355 [Abstract]
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-624, AND MASSSPECTROMETRY.	17203969 [Abstract]