SNUT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNUT1_MOUSE
• UniProt AC: Q9Z315
• Protein Name: U4/U6.U5 tri-snRNP-associated protein 1
• Gene Name: Sart1
• Organism: Mus musculus (Mouse).
• Sequence Length: 806
• Subcellular Localization: Nucleus.
• Protein Description: Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. Appears to play a role in hypoxia-induced regulation of EPO gene expression..
• Protein Sequence: MGSSKKHRGEKEAAGTTAAAGTGGTTEQPPRHREHKKHKHRSSGGGSSGGERRKRSRERGSERGSGRRGAEAEARSGAHGRERSQAEPSERRVKREKRDDGYEAAASSKASSGDASSLSIEETNKLRAKLGLKPLEVNAVKKEAGTKEEPVAADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFEQRRQDLYSARDLQGLTVEHAIDSFREGETVVLTLKDKGVLQDGEDVLVNVNMVDKERADKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILAKYDEELEGERPHSFRLEQGGMADGLRERELEEIRTKLRLQAQSLSSVGPRLASEYLSPEEMVTFKKTKRRVKKIRKKEKEVIMRADDLLPLGDQTQDGDFGSRLRGRGRRRVPEVEEEALEDEEKDPVAQPPPSDDTRVENMDISDEEDGGALPPGSPEGLEEDEAELELQKQLEKGRRLRQLQQLQQLRDSGEKVLEIVKKLESRQRGWEEEEDPERKGTIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGEENIGWSTVNLDEEKQHQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARVKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVALLQEKQKAQKTPYIVLSGSGKSMNANTITK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGSSKKHRGE -----CCCCCCCCCC	37.37	24719451
4	Phosphorylation	----MGSSKKHRGEK ----CCCCCCCCCCC	39.74	24719451
26	Phosphorylation	AAGTGGTTEQPPRHR CCCCCCCCCCCCCCH	35.58	24719451
61	Phosphorylation	KRSRERGSERGSGRR HHHHHHCCCCCCCHH	30.27	18779572
84	Phosphorylation	GAHGRERSQAEPSER CCCCCHHCCCCCCHH	29.05	26824392
102	Phosphorylation	REKRDDGYEAAASSK HHHCCCCHHHHHHCC	14.91	-
111	Phosphorylation	AAASSKASSGDASSL HHHHCCCCCCCCCCC	38.29	28833060
112	Phosphorylation	AASSKASSGDASSLS HHHCCCCCCCCCCCC	45.62	28833060
129	Ubiquitination	ETNKLRAKLGLKPLE HHHHHHHHHCCCCCC	36.33	22790023
189	Phosphorylation	QKLGKIKTLGEDDPW HHHCCCCCCCCCCCC	43.39	22817900
321	Phosphorylation	LPYAEDESVDDLAQQ CCCCCCCCHHHHHHH	43.07	29899451
336	Acetylation	KPRSILAKYDEELEG CCHHHHHHCCHHHCC	50.19	22826441
348	Phosphorylation	LEGERPHSFRLEQGG HCCCCCCCEECCCCC	18.10	27841257
378	Phosphorylation	KLRLQAQSLSSVGPR HHHHHHHHHHCCCHH	32.98	29514104
380	Phosphorylation	RLQAQSLSSVGPRLA HHHHHHHHCCCHHHH	28.37	27600695
388	Phosphorylation	SVGPRLASEYLSPEE CCCHHHHHHHCCHHH	31.22	23984901
390	Phosphorylation	GPRLASEYLSPEEMV CHHHHHHHCCHHHHH	15.24	23984901
392	Phosphorylation	RLASEYLSPEEMVTF HHHHHHCCHHHHHCC	29.39	26824392
398	Phosphorylation	LSPEEMVTFKKTKRR CCHHHHHCCHHHHHH	28.55	23984901
430	Phosphorylation	LLPLGDQTQDGDFGS CCCCCCCCCCCCHHH	33.11	25619855
437	Phosphorylation	TQDGDFGSRLRGRGR CCCCCHHHHCCCCCC	28.30	28066266
469	Phosphorylation	PVAQPPPSDDTRVEN CCCCCCCCCCCCCCC	54.62	27841257
480	Phosphorylation	RVENMDISDEEDGGA CCCCCCCCCCCCCCC	34.40	27818261
492	Phosphorylation	GGALPPGSPEGLEED CCCCCCCCCCCCCCC	26.08	21082442
527	Phosphorylation	QLQQLRDSGEKVLEI HHHHHHHHHHHHHHH	42.28	28066266
597	Phosphorylation	FERDEERSANGGSES HHHHHHHHCCCCCCC	29.39	27087446
602	Phosphorylation	ERSANGGSESDGEEN HHHCCCCCCCCCCCC	35.01	27087446
604	Phosphorylation	SANGGSESDGEENIG HCCCCCCCCCCCCCC	53.25	27087446
613	Phosphorylation	GEENIGWSTVNLDEE CCCCCCCEEECCCHH	19.77	22705319
614	Phosphorylation	EENIGWSTVNLDEEK CCCCCCEEECCCHHH	13.60	30635358
627	Phosphorylation	EKQHQDFSASSTTIL HHHHCCCCCCCCCCC	35.21	-
701	Phosphorylation	REEYRGFTQDFKEKD HHHHCCCCHHHHHHC	30.01	-
727	Phosphorylation	DETGRKLTPKEAFRQ CCCCCCCCHHHHHHH	35.04	26643407
744	Phosphorylation	HRFHGKGSGKMKTER HHHCCCCCCCHHHHH	38.43	29514104
766	Phosphorylation	EALLKKMSSSDTPLG HHHHHHHCCCCCCCH	35.25	26643407
767	Phosphorylation	ALLKKMSSSDTPLGT HHHHHHCCCCCCCHH	28.83	28066266
768	Phosphorylation	LLKKMSSSDTPLGTV HHHHHCCCCCCCHHH	37.89	28066266
770	Phosphorylation	KKMSSSDTPLGTVAL HHHCCCCCCCHHHHH	23.51	28066266
774	Phosphorylation	SSDTPLGTVALLQEK CCCCCCHHHHHHHHH	15.41	22871156
793	Phosphorylation	KTPYIVLSGSGKSMN CCCEEEECCCCCCCC	21.73	29176673
795	Phosphorylation	PYIVLSGSGKSMNAN CEEEECCCCCCCCCC	39.41	29176673
797	Acetylation	IVLSGSGKSMNANTI EEECCCCCCCCCCCC	48.51	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SNUT1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNUT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNUT1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MA2C1_HUMAN	MAN2C1	physical	26496610
IKBL1_HUMAN	NFKBIL1	physical	26496610
MRCKA_HUMAN	CDC42BPA	physical	26496610
PRP4_HUMAN	PRPF4	physical	26496610
PRPF3_HUMAN	PRPF3	physical	26496610
SNR40_HUMAN	SNRNP40	physical	26496610
DDX23_HUMAN	DDX23	physical	26496610
CD2B2_HUMAN	CD2BP2	physical	26496610
PRP8_HUMAN	PRPF8	physical	26496610
SNUT2_HUMAN	USP39	physical	26496610
U520_HUMAN	SNRNP200	physical	26496610
PRP6_HUMAN	PRPF6	physical	26496610
PRP31_HUMAN	PRPF31	physical	26496610
FBXL6_HUMAN	FBXL6	physical	26496610
ASF1B_HUMAN	ASF1B	physical	26496610
KNL1_HUMAN	CASC5	physical	26496610
IFIH1_HUMAN	IFIH1	physical	26496610
DEFM_HUMAN	PDF	physical	26496610
ZGPAT_HUMAN	ZGPAT	physical	26496610
CA198_HUMAN	C1orf198	physical	26496610
CCD84_HUMAN	CCDC84	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.