FBXL6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBXL6_HUMAN
• UniProt AC: Q8N531
• Protein Name: F-box/LRR-repeat protein 6
• Gene Name: FBXL6
• Organism: Homo sapiens (Human).
• Sequence Length: 539
• Protein Description: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex..
• Protein Sequence: MAAPASRQVRRRARAAPRPRSAEDWWWDRLAPRGSGYHLLQSDSMLLVLSEPGPARPRAQRRASRRTPRQPPRGPSAAAKPKAGLRSEAAAAPAPAPAPTPTPEEGPDAGWGDRIPLEILVQIFGLLVAADGPMPFLGRAARVCRRWQEAASQPALWHTVTLSSPLVGRPAKGGVKAEKKLLASLEWLMPNRFSQLQRLTLIHWKSQVHPVLKLVGECCPRLTFLKLSGCHGVTADALVMLAKACCQLHSLDLQHSMVESTAVVSFLEEAGSRMRKLWLTYSSQTTAILGALLGSCCPQLQVLEVSTGINRNSIPLQLPVEALQKGCPQLQVLRLLNLMWLPKPPGRGVAPGPGFPSLEELCLASSTCNFVSNEVLGRLLHGSPNLRLLDLRGCARITPAGLQDLPCRELEQLHLGLYGTSDRLTLAKEGSPFLTQKWCHTLRELDLSGQGFSEKDLEQALAAFLSTPGGSHPALCSLNLRGTRVTPSTVSSVISSCPGLLYLNLESCRCLPRGLKRAYRGLEEVQWCLEQLLTSPSPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	RAAPRPRSAEDWWWD HHCCCCCCHHHCHHH	38.40	22617229
35	Phosphorylation	DRLAPRGSGYHLLQS HHHCCCCCCEEEECC	37.14	22210691
37	Phosphorylation	LAPRGSGYHLLQSDS HCCCCCCEEEECCCC	7.32	22210691
42	Phosphorylation	SGYHLLQSDSMLLVL CCEEEECCCCEEEEE	31.46	22210691
44	Phosphorylation	YHLLQSDSMLLVLSE EEEECCCCEEEEECC	19.31	22210691
76	Phosphorylation	RQPPRGPSAAAKPKA CCCCCCCCCCCCCCC	33.11	20860994
205	Ubiquitination	RLTLIHWKSQVHPVL HHHHHHHHHCCCHHH	19.49	-
325	Ubiquitination	LPVEALQKGCPQLQV CHHHHHHCCCCHHHH	64.43	-
422 (in isoform 2)	Ubiquitination	-	49.82	21890473
422	Ubiquitination	LGLYGTSDRLTLAKE CCCCCCCCCHHHCCC	49.82	21890473
428	Ubiquitination	SDRLTLAKEGSPFLT CCCHHHCCCCCCCHH	66.76	23000965
428 (in isoform 1)	Ubiquitination	-	66.76	21890473
431	Ubiquitination	LTLAKEGSPFLTQKW HHHCCCCCCCHHHHH	17.36	29967540
431	Phosphorylation	LTLAKEGSPFLTQKW HHHCCCCCCCHHHHH	17.36	25159151
437	Ubiquitination	GSPFLTQKWCHTLRE CCCCHHHHHHHHHHH	46.70	29967540
466	Phosphorylation	QALAAFLSTPGGSHP HHHHHHHCCCCCCCC	26.55	28450419
467	Phosphorylation	ALAAFLSTPGGSHPA HHHHHHCCCCCCCCE	28.27	28450419
471	Phosphorylation	FLSTPGGSHPALCSL HHCCCCCCCCEEEEE	32.01	28450419
534	Phosphorylation	WCLEQLLTSPSPS-- HHHHHHHCCCCCC--	47.38	20873877
535	Phosphorylation	CLEQLLTSPSPS--- HHHHHHCCCCCC---	24.29	20873877
537	Phosphorylation	EQLLTSPSPS----- HHHHCCCCCC-----	37.23	25159151
539	Phosphorylation	LLTSPSPS------- HHCCCCCC-------	58.13	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBXL6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBXL6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBXL6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ETV6_HUMAN	ETV6	physical	18426905

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.