STK26_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STK26_MOUSE
• UniProt AC: Q99JT2
• Protein Name: Serine/threonine-protein kinase 26 {ECO:0000305}
• Gene Name: Stk26 {ECO:0000312|MGI:MGI:1917665}
• Organism: Mus musculus (Mouse).
• Sequence Length: 416
• Subcellular Localization: Cytoplasm . Golgi apparatus . Colocalized with RIPOR1 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with RIPOR1 upon serum stimulation in a Rho- and PDCD10-dependent manner.
• Protein Description: Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation..
• Protein Sequence: MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLIGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDEESDSEGSDSESSSRESNPHPEWSFTTVRKKPDPKKLQNGEEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAETACPGITDKMVKKLIEKFQKCSADESP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAHSPVAVQ ------CCCCCEEEE		-
4	Phosphorylation	----MAHSPVAVQVP ----CCCCCEEEECC		24723360
34	Phosphorylation	LERIGKGSFGEVFKG HHHHCCCCHHHHCCC		-
101	Phosphorylation	KLWIIMEYLGGGSAL EEEEEEEHHCCCCHH		26239621
106	Phosphorylation	MEYLGGGSALDLLRA EEHHCCCCHHHHHHH		26643407
130	Acetylation	TMLKEILKGLDYLHS HHHHHHHHHHHHHHC		23954790
170	Phosphorylation	FGVAGQLTDTQIKRN EECCCCCCCCCHHHC		22322096
172	Phosphorylation	VAGQLTDTQIKRNTF CCCCCCCCCHHHCCC		25521595
178	Phosphorylation	DTQIKRNTFVGTPFW CCCHHHCCCCCCCCC		22322096
182	Phosphorylation	KRNTFVGTPFWMAPE HHCCCCCCCCCCCHH		25266776
264	Phosphorylation	KDPSFRPTAKELLKH CCCCCCCCHHHHHHC		26239621
280	Ubiquitination	FIVKNSKKTSYLTEL EEECCCCCCCHHHHH		-
281	Phosphorylation	IVKNSKKTSYLTELI EECCCCCCCHHHHHH		25293948
282	Phosphorylation	VKNSKKTSYLTELID ECCCCCCCHHHHHHH		22817900
283	Phosphorylation	KNSKKTSYLTELIDR CCCCCCCHHHHHHHH		25293948
285	Phosphorylation	SKKTSYLTELIDRFK CCCCCHHHHHHHHHH		25293948
300	Phosphorylation	RWKAEGHSDEESDSE HHHHCCCCCCCCCCC		21149613
304	Phosphorylation	EGHSDEESDSEGSDS CCCCCCCCCCCCCCC		21659605
306	Phosphorylation	HSDEESDSEGSDSES CCCCCCCCCCCCCCC		21659605
309	Phosphorylation	EESDSEGSDSESSSR CCCCCCCCCCCCCCC		21659605
325	Phosphorylation	SNPHPEWSFTTVRKK CCCCCCCCCEECCCC		27600695
327	Phosphorylation	PHPEWSFTTVRKKPD CCCCCCCEECCCCCC		25266776
328	Phosphorylation	HPEWSFTTVRKKPDP CCCCCCEECCCCCCH		25266776
415	Phosphorylation	QKCSADESP------ HHCCCCCCC------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STK26_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STK26_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STK26_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of STK26_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.