NU214_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NU214_MOUSE
• UniProt AC: Q80U93
• Protein Name: Nuclear pore complex protein Nup214
• Gene Name: Nup214
• Organism: Mus musculus (Mouse).
• Sequence Length: 2085
• Subcellular Localization: Nucleus, nuclear pore complex . Cytoplasmic side of the nuclear pore complex.
• Protein Description: May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex..
• Protein Sequence: MGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSVLTISNKYGMLFAGGTNGLNVFPTKSLLIQNKPGDDPNKIVDTIQGLNVPMKFPVHHLALSCDSLTLSACMMSSEYGSIIAFFDVRTFSNQAKPLKRPFTYHKVSNDASGMVNDMKWNPTVPSMVAVCLADGSISVLQVTDVVKVCATLPPSTGVTCVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFTIVYAGADGTLETCPDVVMALLPKKEEKHPEIFVNFMEPCYSSCTERQHHYYLSYIEEWDLVLAASAASTEVSILARQNDQTNWESWLLEDSSRAELPVTDKSDDSLPMGVAIDYTNEVEVTINEEKTLPPAPVLLLLSTDGVLCPFYMINQNPGVRSLIKTLELISTEGERQPKSSGSFPGTPSSPQAPQNLDAPATASSPLPPVSAAPTSTFPMPSAAGSPSVFSFGPSSFKSSASVTGEPPLYPTGSDSSRAAPGSGTSTFSFAPPSKGSLASTPAVAPVATSAAPFTFGFKPTLESTPMSSTPNTGMKPSFPPSASSVKVNLNEKFTAVASSAPVHSSTSTPSVLPFSSSPKPTASGPLSHPTPLPASSSSMPLKSSVSPSPAAGRSTQTAPSSAPSTGQKSPRVNPPVPKSGSSQAKALQPPVTEKQRPQWKDSDPVLAGIGEEIAHFQKELEELKARTAKACLQVGTSEEMKMLRTESDDLHTFLFEIRETTESLHGDISTLKTTLLEGFAGVEEAREQHGRNHDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDRHLEQKKRQRRLIVPERETLFNTLANNREIINQQRKRLNQLVDSLQQLRLYNHTAPWSLPSALSTQSNSHSFDSDLECLLKTTIESHTKPSPRVPGKLSPAKQAQLRNFLAKRKTPPVRSTAPASLSRSAFLSQRYYEDLDEGSSASSVAQPLEGEDARPTCTSVAQPLEGEDAQPICKEEEAVVPVPRHAPVVRTPSIQPSLLPQSMPFAKPHLIHSSSPAVMSSAVSTSATKVIPQGADSTMLATKTVKHGAPGPSHTVAAPQAAAAAALRRQMASQAPAMSTLTESTLKTVPQVVNVQELRSNPSPPSAAMGSAVQHSAAKTPHAVLTPVANSQAKQGSLINSFKPSGPTAASCQLSSGDKAVGQGTAKTESAATSTPSAAGQLNKPFSFASPGTFTFGTITPTPSSSFTATPGAGPPTKEPTQLEAFSFGGGGKPFSEAIPGNSPATGATSAPSTSVTAASLEDSAPSSSKPAAPPETTVSSASSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQAEDSTKPVSKASSTNLAGAQPAKPSGVSFPNTSVLGKPVEPAVTSSVSPAPAAPASALNVSTSSSSATVFGSVPLTSAGPPGLISFGGAALASSKASFSFGNQQTSSSTASSATPTSTSVAPSLPASFPTLSFGGLLSSPSASSLPVSSGKSTEEAAPPAVPDKSDSSEVSATTPSLPVQPQSTQASLQTSDPVKKEPVLVQTTDSSPSRPASSASFVASTESMPVTLGAPDSKIEAVSPASTFAGPGQAAVATAVLPGAGSAATEASGTPTTSTVSSSSPTSATETAVFGTATSGSSVFTQPPAASSSSAFSQLSSNTATAPSATPVFGQVAASITSTAAATPQASSSGFGSPAFGASAPGVFGQTAFGQTPAFGQATSSPASGFSFSQPGFSSVPAFGQSVSSTPASTSANVFGATSSTSSPGSFSFGQASTNTGGTLFGQNNPPAFGQSPGFGQGSSVFGGTSATTSTAAPSGFSFCQASGFGSSNTGSVFGQAANTGGSVFGQSSTSSGGVFGSGNATRGGGFFSGLGGKPSQDAANKNPFSSAGGGFGSTAAPNTSNLFGNSGAKTFGGFGSSSFGEQKPAGTFSSGGGSVASQGFGFSTPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSGNTASFGTLASQNAPTFGSLSQQTSGFGTPSSGFAGFGSGTGAFTFGSSNSSVQGFGGWRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGDEMDAMI ------CCHHHHHCC	51.38	-
30	Phosphorylation	KKVRIFDSPEELPKE EEEEECCCHHHCCCH	24.38	28066266
48	Phosphorylation	VLTISNKYGMLFAGG CEEEECCCEEEECCC	16.42	-
193	Ubiquitination	CATLPPSTGVTCVCW HCCCCCCCCEEEEEE	41.25	27667366
205	Malonylation	VCWSPKGKQLAVGKQ EEECCCCCEEEEECC	48.54	26320211
416	Phosphorylation	GVRSLIKTLELISTE CHHHHHHHHHHHCCC	20.62	-
421	Phosphorylation	IKTLELISTEGERQP HHHHHHHCCCCCCCC	32.79	-
430	Phosphorylation	EGERQPKSSGSFPGT CCCCCCCCCCCCCCC	46.76	-
433	Phosphorylation	RQPKSSGSFPGTPSS CCCCCCCCCCCCCCC	30.16	-
437	Phosphorylation	SSGSFPGTPSSPQAP CCCCCCCCCCCCCCC	21.89	-
489	Phosphorylation	FGPSSFKSSASVTGE CCCHHCCCCCCCCCC	29.17	28833060
490	Phosphorylation	GPSSFKSSASVTGEP CCHHCCCCCCCCCCC	25.75	28833060
492	Phosphorylation	SSFKSSASVTGEPPL HHCCCCCCCCCCCCC	23.35	25521595
494	Phosphorylation	FKSSASVTGEPPLYP CCCCCCCCCCCCCCC	33.08	28833060
504	O-linked_Glycosylation	PPLYPTGSDSSRAAP CCCCCCCCCCCCCCC	36.48	30059200
507	O-linked_Glycosylation	YPTGSDSSRAAPGSG CCCCCCCCCCCCCCC	30.81	30059200
513	Phosphorylation	SSRAAPGSGTSTFSF CCCCCCCCCCCCEEE	37.53	26745281
513	O-linked_Glycosylation	SSRAAPGSGTSTFSF CCCCCCCCCCCCEEE	37.53	30059200
515	Phosphorylation	RAAPGSGTSTFSFAP CCCCCCCCCCEEECC	26.70	26745281
516	Phosphorylation	AAPGSGTSTFSFAPP CCCCCCCCCEEECCC	30.86	26745281
517	Phosphorylation	APGSGTSTFSFAPPS CCCCCCCCEEECCCC	24.12	28066266
518	Ubiquitination	PGSGTSTFSFAPPSK CCCCCCCEEECCCCC	5.91	27667366
519	Phosphorylation	GSGTSTFSFAPPSKG CCCCCCEEECCCCCC	22.16	25777480
524	Phosphorylation	TFSFAPPSKGSLAST CEEECCCCCCCCCCC	48.90	25777480
539	Phosphorylation	PAVAPVATSAAPFTF CCCCCCCCCCCCEEC	21.09	26643407
540	Phosphorylation	AVAPVATSAAPFTFG CCCCCCCCCCCEECC	16.82	26643407
545	Phosphorylation	ATSAAPFTFGFKPTL CCCCCCEECCCCCCC	23.07	26643407
551	Phosphorylation	FTFGFKPTLESTPMS EECCCCCCCCCCCCC	43.69	26643407
554	Phosphorylation	GFKPTLESTPMSSTP CCCCCCCCCCCCCCC	40.71	26643407
555	Phosphorylation	FKPTLESTPMSSTPN CCCCCCCCCCCCCCC	17.40	26643407
558	Phosphorylation	TLESTPMSSTPNTGM CCCCCCCCCCCCCCC	32.06	26643407
559	Phosphorylation	LESTPMSSTPNTGMK CCCCCCCCCCCCCCC	41.45	26643407
560	Phosphorylation	ESTPMSSTPNTGMKP CCCCCCCCCCCCCCC	17.16	26643407
563	Phosphorylation	PMSSTPNTGMKPSFP CCCCCCCCCCCCCCC	39.60	26643407
597	Phosphorylation	SAPVHSSTSTPSVLP CCCCCCCCCCCCCCC	39.37	26643407
598	Phosphorylation	APVHSSTSTPSVLPF CCCCCCCCCCCCCCC	40.02	26643407
599	Phosphorylation	PVHSSTSTPSVLPFS CCCCCCCCCCCCCCC	21.48	26643407
601	Phosphorylation	HSSTSTPSVLPFSSS CCCCCCCCCCCCCCC	36.05	26643407
606	Phosphorylation	TPSVLPFSSSPKPTA CCCCCCCCCCCCCCC	28.15	26643407
607	Phosphorylation	PSVLPFSSSPKPTAS CCCCCCCCCCCCCCC	51.55	26643407
608	Phosphorylation	SVLPFSSSPKPTASG CCCCCCCCCCCCCCC	35.43	26643407
634	Phosphorylation	SSSMPLKSSVSPSPA CCCCCCCCCCCCCCC	43.59	25159016
635	Phosphorylation	SSMPLKSSVSPSPAA CCCCCCCCCCCCCCC	25.65	25159016
637	Phosphorylation	MPLKSSVSPSPAAGR CCCCCCCCCCCCCCC	22.93	26824392
639	Phosphorylation	LKSSVSPSPAAGRST CCCCCCCCCCCCCCC	21.47	25159016
645	Phosphorylation	PSPAAGRSTQTAPSS CCCCCCCCCCCCCCC	24.77	25619855
646	Phosphorylation	SPAAGRSTQTAPSSA CCCCCCCCCCCCCCC	28.69	25619855
648	Phosphorylation	AAGRSTQTAPSSAPS CCCCCCCCCCCCCCC	40.39	25619855
651	Phosphorylation	RSTQTAPSSAPSTGQ CCCCCCCCCCCCCCC	36.35	25619855
652	Phosphorylation	STQTAPSSAPSTGQK CCCCCCCCCCCCCCC	43.04	25619855
655	Phosphorylation	TAPSSAPSTGQKSPR CCCCCCCCCCCCCCC	44.90	25619855
656	Phosphorylation	APSSAPSTGQKSPRV CCCCCCCCCCCCCCC	42.44	23684622
659	Ubiquitination	SAPSTGQKSPRVNPP CCCCCCCCCCCCCCC	64.87	-
660	Phosphorylation	APSTGQKSPRVNPPV CCCCCCCCCCCCCCC	15.28	25521595
672	Phosphorylation	PPVPKSGSSQAKALQ CCCCCCCCHHHHHCC	26.77	-
732	Ubiquitination	VGTSEEMKMLRTESD CCCHHHHHHHHCCCC	37.75	22790023
754	Phosphorylation	EIRETTESLHGDIST HHHHHHHHHCCCHHH	24.47	-
788	Phosphorylation	GRNHDSGYLHLLYKR CCCCCCCEEEEEECC	8.56	22817900
889	Phosphorylation	YNHTAPWSLPSALST CCCCCCCCCCCHHHC	29.37	23984901
892	Phosphorylation	TAPWSLPSALSTQSN CCCCCCCCHHHCCCC	47.32	23984901
895	Phosphorylation	WSLPSALSTQSNSHS CCCCCHHHCCCCCCC	24.90	23984901
896	Phosphorylation	SLPSALSTQSNSHSF CCCCHHHCCCCCCCC	36.55	23984901
898	Phosphorylation	PSALSTQSNSHSFDS CCHHHCCCCCCCCCC	40.15	23984901
900	Phosphorylation	ALSTQSNSHSFDSDL HHHCCCCCCCCCCHH	26.25	23984901
902	Phosphorylation	STQSNSHSFDSDLEC HCCCCCCCCCCHHHH	30.48	23984901
905	Phosphorylation	SNSHSFDSDLECLLK CCCCCCCCHHHHHHH	41.93	23984901
919	Phosphorylation	KTTIESHTKPSPRVP HHHHHHCCCCCCCCC	54.66	29514104
920	Ubiquitination	TTIESHTKPSPRVPG HHHHHCCCCCCCCCC	37.77	22790023
922	Phosphorylation	IESHTKPSPRVPGKL HHHCCCCCCCCCCCC	27.22	28507225
930	Phosphorylation	PRVPGKLSPAKQAQL CCCCCCCCHHHHHHH	26.71	26824392
960	Phosphorylation	APASLSRSAFLSQRY CCHHHCHHHHHHHHH	21.72	22006019
964	Phosphorylation	LSRSAFLSQRYYEDL HCHHHHHHHHHHHCC	13.22	22006019
979	Phosphorylation	DEGSSASSVAQPLEG CCCCCCCCCCCCCCC	22.61	-
1027	Phosphorylation	RHAPVVRTPSIQPSL CCCCCCCCCCCCHHH	15.13	25266776
1029	Phosphorylation	APVVRTPSIQPSLLP CCCCCCCCCCHHHCC	32.99	30352176
1033	Phosphorylation	RTPSIQPSLLPQSMP CCCCCCHHHCCCCCC	26.60	26643407
1049	O-linked_Glycosylation	AKPHLIHSSSPAVMS CCCCEECCCCHHHHC	26.05	30059200
1049	Phosphorylation	AKPHLIHSSSPAVMS CCCCEECCCCHHHHC	26.05	26643407
1050	Phosphorylation	KPHLIHSSSPAVMSS CCCEECCCCHHHHCC	26.61	26643407
1051	Phosphorylation	PHLIHSSSPAVMSSA CCEECCCCHHHHCCC	21.64	26643407
1062	Phosphorylation	MSSAVSTSATKVIPQ HCCCCCCCCCEEECC	26.83	-
1091	O-linked_Glycosylation	GAPGPSHTVAAPQAA CCCCCCCCCHHHHHH	19.04	30059200
1124	O-linked_Glycosylation	LTESTLKTVPQVVNV CCHHHHCCCCEEECH	40.30	55413025
1136	Phosphorylation	VNVQELRSNPSPPSA ECHHHHHCCCCCCHH	66.76	27087446
1139	Phosphorylation	QELRSNPSPPSAAMG HHHHCCCCCCHHHHH	54.41	25521595
1142	Phosphorylation	RSNPSPPSAAMGSAV HCCCCCCHHHHHHHH	31.85	25521595
1147	Phosphorylation	PPSAAMGSAVQHSAA CCHHHHHHHHHHCCC	16.51	25619855
1152	Phosphorylation	MGSAVQHSAAKTPHA HHHHHHHCCCCCCCE	16.90	25619855
1156	Phosphorylation	VQHSAAKTPHAVLTP HHHCCCCCCCEEEEC	18.64	28066266
1162	Phosphorylation	KTPHAVLTPVANSQA CCCCEEEECCCCCHH	14.76	24453211
1167	O-linked_Glycosylation	VLTPVANSQAKQGSL EEECCCCCHHHCCCC	23.06	55413019
1187	Phosphorylation	PSGPTAASCQLSSGD CCCCCCCEEECCCCC	10.42	-
1313	Phosphorylation	KPAAPPETTVSSASS CCCCCCCCCCCCCCC	37.97	26643407
1314	Phosphorylation	PAAPPETTVSSASSK CCCCCCCCCCCCCCC	19.41	26643407
1316	Phosphorylation	APPETTVSSASSKLE CCCCCCCCCCCCCCC	20.35	26643407
1317	Phosphorylation	PPETTVSSASSKLET CCCCCCCCCCCCCCC	28.03	26643407
1319	Phosphorylation	ETTVSSASSKLETPP CCCCCCCCCCCCCCC	29.92	26643407
1320	Phosphorylation	TTVSSASSKLETPPS CCCCCCCCCCCCCCH	40.76	26643407
1324	Phosphorylation	SASSKLETPPSKLGE CCCCCCCCCCHHHHH	51.43	28833060
1327	Phosphorylation	SKLETPPSKLGELLF CCCCCCCHHHHHHHC	41.54	28833060
1328	Ubiquitination	KLETPPSKLGELLFP CCCCCCHHHHHHHCC	67.30	-
1337	O-linked_Glycosylation	GELLFPSSLAGETLG HHHHCCHHHCCCCCC	23.60	30059200
1362	O-linked_Glycosylation	EDSTKPVSKASSTNL CCCCCCCCCCCCCCC	30.91	30059200
1365	Phosphorylation	TKPVSKASSTNLAGA CCCCCCCCCCCCCCC	41.24	29472430
1366	Phosphorylation	KPVSKASSTNLAGAQ CCCCCCCCCCCCCCC	26.61	29472430
1367	Phosphorylation	PVSKASSTNLAGAQP CCCCCCCCCCCCCCC	31.58	29472430
1527	Phosphorylation	SSEVSATTPSLPVQP CCCCCCCCCCCCCCC	15.59	25338131
1556	Phosphorylation	KEPVLVQTTDSSPSR CCCEEEEECCCCCCC	25.70	23649490
1557	O-linked_Glycosylation	EPVLVQTTDSSPSRP CCEEEEECCCCCCCC	19.45	30059200
1557	Phosphorylation	EPVLVQTTDSSPSRP CCEEEEECCCCCCCC	19.45	28066266
1559	Phosphorylation	VLVQTTDSSPSRPAS EEEEECCCCCCCCCC	41.90	26643407
1560	Phosphorylation	LVQTTDSSPSRPASS EEEECCCCCCCCCCC	29.70	26643407
1562	Phosphorylation	QTTDSSPSRPASSAS EECCCCCCCCCCCCC	53.49	28066266
1566	Phosphorylation	SSPSRPASSASFVAS CCCCCCCCCCCEEEE	29.17	25777480
1567	Phosphorylation	SPSRPASSASFVAST CCCCCCCCCCEEEEC	30.00	25777480
1569	Phosphorylation	SRPASSASFVASTES CCCCCCCCEEEECCC	23.38	23649490
1573	Phosphorylation	SSASFVASTESMPVT CCCCEEEECCCCCEE	27.66	23649490
1574	Phosphorylation	SASFVASTESMPVTL CCCEEEECCCCCEEE	23.49	25777480
1576	Phosphorylation	SFVASTESMPVTLGA CEEEECCCCCEEECC	28.60	25777480
1580	Phosphorylation	STESMPVTLGAPDSK ECCCCCEEECCCCHH	17.38	25777480
1586	Phosphorylation	VTLGAPDSKIEAVSP EEECCCCHHEEEECC	34.18	25777480
1899	O-linked_Glycosylation	AANKNPFSSAGGGFG HHHCCCCCCCCCCCC	22.12	30059200
1943	Phosphorylation	QKPAGTFSSGGGSVA CCCCCCCCCCCCCCC	28.10	26745281
1944	Phosphorylation	KPAGTFSSGGGSVAS CCCCCCCCCCCCCCC	36.95	26745281
1948	Phosphorylation	TFSSGGGSVASQGFG CCCCCCCCCCCCCCC	20.13	26745281
1951	Phosphorylation	SGGGSVASQGFGFST CCCCCCCCCCCCCCC	28.78	26745281
1957	Phosphorylation	ASQGFGFSTPNKTGG CCCCCCCCCCCCCCC	43.25	26643407
1958	Phosphorylation	SQGFGFSTPNKTGGF CCCCCCCCCCCCCCC	28.72	26643407
1962	Phosphorylation	GFSTPNKTGGFGAAP CCCCCCCCCCCCCCC	49.53	25293948
1973	Phosphorylation	GAAPVFGSPPTFGGS CCCCCCCCCCCCCCC	19.08	26643407
1976	Phosphorylation	PVFGSPPTFGGSPGF CCCCCCCCCCCCCCC	37.99	26643407
1980	Phosphorylation	SPPTFGGSPGFGGVP CCCCCCCCCCCCCCC	23.41	26643407
1991	Phosphorylation	GGVPAFGSAPAFTSP CCCCCCCCCCCCCCC	25.32	25293948
1996	Phosphorylation	FGSAPAFTSPLGSTG CCCCCCCCCCCCCCC	31.38	25293948
1997	Phosphorylation	GSAPAFTSPLGSTGG CCCCCCCCCCCCCCC	16.21	26745281
2001	Phosphorylation	AFTSPLGSTGGKVFG CCCCCCCCCCCCEEC	31.40	26745281
2002	Phosphorylation	FTSPLGSTGGKVFGE CCCCCCCCCCCEECC	48.43	25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NU214_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NU214_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NU214_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUP62_HUMAN	NUP62	physical	20360068
NUP93_HUMAN	NUP93	physical	20360068
NUP88_HUMAN	NUP88	physical	20360068
NU188_HUMAN	NUP188	physical	20360068
NUP98_HUMAN	NUP98	physical	20360068
OGT1_HUMAN	OGT	physical	20360068
RAE1L_HUMAN	RAE1	physical	20360068
NU214_HUMAN	NUP214	physical	20360068
CO7A1_HUMAN	COL7A1	physical	26496610
HEXB_HUMAN	HEXB	physical	26496610
NUP88_HUMAN	NUP88	physical	26496610
NUP98_HUMAN	NUP98	physical	26496610
RBP2_HUMAN	RANBP2	physical	26496610
RAGP1_HUMAN	RANGAP1	physical	26496610
STAT2_HUMAN	STAT2	physical	26496610
STX3_HUMAN	STX3	physical	26496610
RAE1L_HUMAN	RAE1	physical	26496610
K2C75_HUMAN	KRT75	physical	26496610
CYH1_HUMAN	CYTH1	physical	26496610
NU155_HUMAN	NUP155	physical	26496610
SAFB2_HUMAN	SAFB2	physical	26496610
NUP93_HUMAN	NUP93	physical	26496610
NU153_HUMAN	NUP153	physical	26496610
NU205_HUMAN	NUP205	physical	26496610
PO210_HUMAN	NUP210	physical	26496610
NU160_HUMAN	NUP160	physical	26496610
NU188_HUMAN	NUP188	physical	26496610
NUP62_HUMAN	NUP62	physical	26496610
MED4_HUMAN	MED4	physical	26496610
NU133_HUMAN	NUP133	physical	26496610
NU107_HUMAN	NUP107	physical	26496610
NUP85_HUMAN	NUP85	physical	26496610
SEH1_HUMAN	SEH1L	physical	26496610
NUP53_HUMAN	NUP35	physical	26496610
NUP43_HUMAN	NUP43	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-930, AND MASSSPECTROMETRY.
PubMed: 19144319