CYH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CYH1_HUMAN
• UniProt AC: Q15438
• Protein Name: Cytohesin-1
• Gene Name: CYTH1 {ECO:0000312|HGNC:HGNC:9501}
• Organism: Homo sapiens (Human).
• Sequence Length: 398
• Subcellular Localization: Cell membrane ; Peripheral membrane protein . Cytoplasm, cytosol . Cell junction, tight junction . Cell junction, adherens junction . Colocalized with TJP1 during epithelial polarization.
• Protein Description: Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity..
• Protein Sequence: MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEEDDSYV -------CCCCCCCC	13.20	22814378
7	Phosphorylation	-MEEDDSYVPSDLTA -CCCCCCCCCCCCCH	24.31	27642862
12	Ubiquitination	DSYVPSDLTAEERQE CCCCCCCCCHHHHHH	6.00	-
27	Ubiquitination	LENIRRRKQELLADI HHHHHHHHHHHHHHH	46.44	-
38	Ubiquitination	LADIQRLKDEIAEVA HHHHHHHHHHHHHHH	56.34	-
53	Phosphorylation	NEIENLGSTEERKNM HHHHHCCCHHHHHHH	35.49	30576142
54	Phosphorylation	EIENLGSTEERKNMQ HHHHCCCHHHHHHHH	39.81	27732954
101	Ubiquitination	CEDIAQFLYKGEGLN HHHHHHHHHCCCCCC	2.61	-
103	Ubiquitination	DIAQFLYKGEGLNKT HHHHHHHCCCCCCCC	53.27	-
160	Ubiquitination	RLPGEAQKIDRMMEA CCCCHHHHHHHHHHH	54.33	-
236	Phosphorylation	EELLRNLYESIKNEP HHHHHHHHHHHHCCC	15.92	27067055
238	Phosphorylation	LLRNLYESIKNEPFK HHHHHHHHHHCCCCC	25.88	27067055
240	Ubiquitination	RNLYESIKNEPFKIP HHHHHHHHCCCCCCC	65.62	-
245	Ubiquitination	SIKNEPFKIPEDDGN HHHCCCCCCCCCCCC	68.98	-
255	Phosphorylation	EDDGNDLTHTFFNPD CCCCCCCCCCCCCCC	23.02	27067055
257	Phosphorylation	DGNDLTHTFFNPDRE CCCCCCCCCCCCCCC	25.37	27067055
269	Ubiquitination	DREGWLLKLGGGRVK CCCCEEEEECCCCCC	42.80	-
277	Phosphorylation	LGGGRVKTWKRRWFI ECCCCCCEEEEEEEE	33.10	24719451
358	Phosphorylation	NHTVYRISAPTPEEK CEEEEEEECCCHHHH	21.14	28387310
361	Phosphorylation	VYRISAPTPEEKEEW EEEEECCCHHHHHHH	42.94	28387310
365	Ubiquitination	SAPTPEEKEEWIKCI ECCCHHHHHHHHHHH	60.31	-
370	Ubiquitination	EEKEEWIKCIKAAIS HHHHHHHHHHHHHHH	30.86	-
382	Phosphorylation	AISRDPFYEMLAARK HHHCCHHHHHHHHHH	13.05	21945579
393	Phosphorylation	AARKKKVSSTKRH-- HHHHHHCCCCCCC--	40.96	11438522
394	Phosphorylation	ARKKKVSSTKRH--- HHHHHCCCCCCC---	40.72	11438522
395	Phosphorylation	RKKKVSSTKRH---- HHHHCCCCCCC----	25.29	11438522

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
394	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
394	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
395	T	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
395	T	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CYH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CYH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARFRP_HUMAN	ARFRP1	physical	10092663
ITB2_HUMAN	ITGB2	physical	10835351
CYTIP_HUMAN	CYTIP	physical	11867758
TRI23_HUMAN	TRIM23	physical	10748148
GNAQ_HUMAN	GNAQ	physical	17846866
ARRB2_HUMAN	ARRB2	physical	17846866
ARF6_HUMAN	ARF6	physical	17846866
ARRB1_HUMAN	ARRB1	physical	17846866

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.