CYTIP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CYTIP_HUMAN
• UniProt AC: O60759
• Protein Name: Cytohesin-interacting protein
• Gene Name: CYTIP
• Organism: Homo sapiens (Human).
• Sequence Length: 359
• Subcellular Localization: Cytoplasm. Early endosome. Recruited from the cytosol to endosomes by SNX27.
• Protein Description: By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm..
• Protein Sequence: MSLQRLLQHSSNGNLADFCAGPAYSSYSTLTGSLTMDDNRRIQMLADTVATLPRGRKQLALTRSSSLSDFSWSQRKLVTVEKQDNETFGFEIQSYRPQNQNACSSEMFTLICKIQEDSPAHCAGLQAGDVLANINGVSTEGFTYKQVVDLIRSSGNLLTIETLNGTMILKRTELEAKLQVLKQTLKQKWVEYRSLQLQEHRLLHGDAANCPSLENMDLDELSLFGPLPGPGPALVDRNRLSSESSCKSWLSSMTMDSEDGYQTCVSEDSSRGAFSRQTSTDDECFIPKEGDDFLRRSSSRRNRSISNTSSGSMSPLWEGNLSSMFGTLPRKSRKGSVRKQLLKFIPGLHRAVEEEESRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	LQRLLQHSSNGNLAD HHHHHHHCCCCCHHH	16.73	27080861
11	Phosphorylation	QRLLQHSSNGNLADF HHHHHHCCCCCHHHH	46.78	27080861
48	Phosphorylation	RIQMLADTVATLPRG HHHHHHHHHHHCCCC	13.36	23684312
51	Phosphorylation	MLADTVATLPRGRKQ HHHHHHHHCCCCHHH	32.72	23684312
57	Ubiquitination	ATLPRGRKQLALTRS HHCCCCHHHHEEECC	53.11	-
64	Phosphorylation	KQLALTRSSSLSDFS HHHEEECCCCCHHCC	21.02	20058876
65	Phosphorylation	QLALTRSSSLSDFSW HHEEECCCCCHHCCC	31.82	20058876
66	Phosphorylation	LALTRSSSLSDFSWS HEEECCCCCHHCCCC	32.89	23401153
68	Phosphorylation	LTRSSSLSDFSWSQR EECCCCCHHCCCCEE	38.26	23684312
71	Phosphorylation	SSSLSDFSWSQRKLV CCCCHHCCCCEEEEE	30.70	26434776
73	Phosphorylation	SLSDFSWSQRKLVTV CCHHCCCCEEEEEEE	20.93	18077418
76	Ubiquitination	DFSWSQRKLVTVEKQ HCCCCEEEEEEEEEC	39.41	-
154	Phosphorylation	VVDLIRSSGNLLTIE HHHHHHCCCCEEEEE	23.11	-
170	Ubiquitination	LNGTMILKRTELEAK ECCCEEEEHHHHHHH	46.48	-
172	Phosphorylation	GTMILKRTELEAKLQ CCEEEEHHHHHHHHH	43.25	23403867
177	Ubiquitination	KRTELEAKLQVLKQT EHHHHHHHHHHHHHH	30.03	-
182	Ubiquitination	EAKLQVLKQTLKQKW HHHHHHHHHHHHHHH	42.24	-
222	Phosphorylation	NMDLDELSLFGPLPG CCCHHHHHHCCCCCC	21.43	27067055
241	Phosphorylation	LVDRNRLSSESSCKS CCCCCCCCCCHHHHH	28.90	28348404
242	Phosphorylation	VDRNRLSSESSCKSW CCCCCCCCCHHHHHH	46.20	28348404
254	Phosphorylation	KSWLSSMTMDSEDGY HHHHHHCCCCCCCCC	21.55	-
270	Phosphorylation	TCVSEDSSRGAFSRQ EECCCCCCCCCCCCC	47.24	-
278	Phosphorylation	RGAFSRQTSTDDECF CCCCCCCCCCCCCCC	32.27	28450419
279	Phosphorylation	GAFSRQTSTDDECFI CCCCCCCCCCCCCCC	22.85	29978859
280	Phosphorylation	AFSRQTSTDDECFIP CCCCCCCCCCCCCCC	51.35	28450419
304	Phosphorylation	SSSRRNRSISNTSSG CCCCCCCCCCCCCCC	33.64	27251275
306	Phosphorylation	SRRNRSISNTSSGSM CCCCCCCCCCCCCCC	34.99	27080861
308	Phosphorylation	RNRSISNTSSGSMSP CCCCCCCCCCCCCCC	19.92	27080861
309	Phosphorylation	NRSISNTSSGSMSPL CCCCCCCCCCCCCCC	36.63	27080861
310	Phosphorylation	RSISNTSSGSMSPLW CCCCCCCCCCCCCCC	32.61	27080861
312	Phosphorylation	ISNTSSGSMSPLWEG CCCCCCCCCCCCCCC	20.31	22115753
314	Phosphorylation	NTSSGSMSPLWEGNL CCCCCCCCCCCCCCH	20.66	22115753
322	Phosphorylation	PLWEGNLSSMFGTLP CCCCCCHHHHHCCCC	24.61	-
323	Phosphorylation	LWEGNLSSMFGTLPR CCCCCHHHHHCCCCC	22.69	-
357	Phosphorylation	RAVEEEESRF----- HHHHHHHHCC-----	42.12	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CYTIP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CYTIP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CYTIP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SOCS1_HUMAN	SOCS1	physical	23469018
CYH1_HUMAN	CYTH1	physical	23469018
CYH3_HUMAN	CYTH3	physical	26186194
CYH1_HUMAN	CYTH1	physical	26186194
CYH2_HUMAN	CYTH2	physical	26186194
BLK_HUMAN	BLK	physical	26186194
ABRX2_HUMAN	FAM175B	physical	26186194
EDEM2_HUMAN	EDEM2	physical	26186194
HBB_HUMAN	HBB	physical	26186194
CYH1_HUMAN	CYTH1	physical	28514442
CYH3_HUMAN	CYTH3	physical	28514442
CYH2_HUMAN	CYTH2	physical	28514442
ABRX2_HUMAN	FAM175B	physical	28514442
EDEM2_HUMAN	EDEM2	physical	28514442
HBB_HUMAN	HBB	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.