EDEM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EDEM2_HUMAN
• UniProt AC: Q9BV94
• Protein Name: ER degradation-enhancing alpha-mannosidase-like protein 2
• Gene Name: EDEM2
• Organism: Homo sapiens (Human).
• Sequence Length: 578
• Subcellular Localization: Endoplasmic reticulum lumen .
• Protein Description: Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2. [PubMed: 25092655 Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.]
• Protein Sequence: MPFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHYRERVKAMFYHAYDSYLENAFPFDELRPLTCDGHDTWGSFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQARERKPAKQKVPLLSCPSQPFTSKLALLGQVFLDSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	N-linked_Glycosylation	DTLLILGNVSEFQRV HHHHHCCCHHHHHHH	30.60	UniProtKB CARBOHYD
98	Ubiquitination	VSEFQRVVEVLQDSV HHHHHHHHHHHHHCC	4.60	29967540
112	N-linked_Glycosylation	VDFDIDVNASVFETN CCEECCCCCCHHCCC	23.81	UniProtKB CARBOHYD
135	Ubiquitination	SAHLLSKKAGVEVEA HHHHHHCCCCCEEEC	47.17	29967540
275	Ubiquitination	AILLQDKKLMAMFLE HHHHCCHHHHHHHHH	52.35	-
283	Phosphorylation	LMAMFLEYNKAIRNY HHHHHHHHHHHHHHC	24.90	27134283
289	N-linked_Glycosylation	EYNKAIRNYTRFDDW HHHHHHHHCCCCCCE	36.09	UniProtKB CARBOHYD
291	Phosphorylation	NKAIRNYTRFDDWYL HHHHHHCCCCCCEEE	28.54	22210691
365 (in isoform 2)	Ubiquitination	-	74.31	21906983
365	Ubiquitination	GYTVEKREGYPLRPE CCEEEECCCCCCCHH	74.31	22817900
368	Ubiquitination	VEKREGYPLRPELIE EEECCCCCCCHHHHH	32.52	22817900
377	Ubiquitination	RPELIESAMYLYRAT CHHHHHHHHHHHHHH	4.28	29967540
384	Phosphorylation	AMYLYRATGDPTLLE HHHHHHHHCCCHHHH	32.87	25690035
388	Phosphorylation	YRATGDPTLLELGRD HHHHCCCHHHHHCHH	49.03	25690035
402 (in isoform 1)	Ubiquitination	-	51.08	21906983
402	Ubiquitination	DAVESIEKISKVECG HHHHHHHHHHCCCCC	51.08	21906983
405	Ubiquitination	ESIEKISKVECGFAT HHHHHHHCCCCCEEE	45.59	22817900
412	Phosphorylation	KVECGFATIKDLRDH CCCCCEEEHHHHHHC	26.71	28060719
414	Ubiquitination	ECGFATIKDLRDHKL CCCEEEHHHHHHCCC	46.48	29967540
450	N-linked_Glycosylation	PTNFIHNNGSTFDAV CCCCCCCCCCCCCEE	31.46	UniProtKB CARBOHYD
455	Ubiquitination	HNNGSTFDAVITPYG CCCCCCCCEEEECCC	39.76	22817900
455 (in isoform 2)	Ubiquitination	-	39.76	21906983
480	Ubiquitination	FNTEAHPIDPAALHC ECCCCCCCCHHHHHH	7.71	29967540
492	Ubiquitination	LHCCQRLKEEQWEVE HHHHHHHHHHCCCHH	62.49	22817900
492 (in isoform 1)	Ubiquitination	-	62.49	21906983
507	Phosphorylation	DLMREFYSLKRSRSK HHHHHHHHHHHHHHH	32.51	24719451
517	Ubiquitination	RSRSKFQKNTVSSGP HHHHHHCCCCCCCCC	58.69	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EDEM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EDEM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EDEM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RICI_RICCO	RCOM_2159910	physical	24200403
SE1L1_HUMAN	SEL1L	physical	24910992
CALX_HUMAN	CANX	physical	24910992
UHMK1_HUMAN	UHMK1	physical	28514442
HACD1_HUMAN	PTPLA	physical	28514442
CC033_HUMAN	C3orf33	physical	28514442
TXD11_HUMAN	TXNDC11	physical	28514442
B3GN2_HUMAN	B3GNT2	physical	28514442
S35B2_HUMAN	SLC35B2	physical	28514442
MCU_HUMAN	MCU	physical	28514442
MOT10_HUMAN	SLC16A10	physical	28514442
OS9_HUMAN	OS9	physical	28514442
SURF1_HUMAN	SURF1	physical	28514442
BLK_HUMAN	BLK	physical	28514442
TIM29_HUMAN	C19orf52	physical	28514442
GDC_HUMAN	SLC25A16	physical	28514442
S38AA_HUMAN	SLC38A10	physical	28514442
TMTC4_HUMAN	TMTC4	physical	28514442
TV23C_HUMAN	TVP23C	physical	28514442
MCL1_HUMAN	MCL1	physical	28514442
SFXN3_HUMAN	SFXN3	physical	28514442
OMA1_HUMAN	OMA1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.