UHMK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UHMK1_HUMAN
• UniProt AC: Q8TAS1
• Protein Name: Serine/threonine-protein kinase Kist
• Gene Name: UHMK1
• Organism: Homo sapiens (Human).
• Sequence Length: 419
• Subcellular Localization: Nucleus .
• Protein Description: Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity)..
• Protein Sequence: MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVVEDVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Ubiquitination	GSPPGALKQFLPPGT CCCCCHHHHHCCCCC	38.17	-
116	Ubiquitination	LLLELLDVSVSELLL HHHHHHCCCHHHHHH	6.50	21963094
181	Phosphorylation	KLIDFGLSFKEGNQD HHHEECCCCCCCCCC	34.35	24719451
183	Ubiquitination	IDFGLSFKEGNQDVK HEECCCCCCCCCCEE	62.43	-
190 (in isoform 1)	Ubiquitination	-	44.95	21906983
190	Ubiquitination	KEGNQDVKYIQTDGY CCCCCCEEEEECCCC	44.95	21906983
190 (in isoform 2)	Ubiquitination	-	44.95	21906983
191	Ubiquitination	EGNQDVKYIQTDGYR CCCCCEEEEECCCCC	9.71	21963094
197	Phosphorylation	KYIQTDGYRAPEAEL EEEECCCCCCCHHHH	13.35	-
208	Ubiquitination	EAELQNCLAQAGLQS HHHHHHHHHHHCCCC	5.33	22817900
251	Ubiquitination	TVRSQEWKANSSAII HHHCCCHHCCHHHHH	36.62	-
265	Ubiquitination	IDHIFASKAVVNAAI HHHHHHCHHHHHHHC	41.59	21963094
282 (in isoform 1)	Ubiquitination	-	36.79	21906983
282	Ubiquitination	YHLRDLIKSMLHDDP HHHHHHHHHHCCCCH	36.79	22817900
282 (in isoform 2)	Ubiquitination	-	36.79	21906983
283	Phosphorylation	HLRDLIKSMLHDDPS HHHHHHHHHCCCCHH	21.41	27251275
290	Ubiquitination	SMLHDDPSRRIPAEM HHCCCCHHHCCCHHH	40.98	29967540
290	Phosphorylation	SMLHDDPSRRIPAEM HHCCCCHHHCCCHHH	40.98	-
309	Ubiquitination	PFFSIPFAPHIEDLV CCCCCCCCCCHHHHH	6.87	22817900
313	Ubiquitination	IPFAPHIEDLVMLPT CCCCCCHHHHHCCCH	42.11	22817900
340	Phosphorylation	YLENEEEYEDVVEDV HCCCHHHHHHHHHHH	22.25	27642862
364	Ubiquitination	VVSLLVPKENPGRGQ EEEEEEECCCCCCCE	63.74	29967540
383 (in isoform 1)	Ubiquitination	-	53.10	21906983
383	Ubiquitination	YANAGDSKAAQKLLT ECCCCCCHHHHHHHH	53.10	27667366
387	Ubiquitination	GDSKAAQKLLTGRMF CCCHHHHHHHHCCCC	40.51	22817900
397	Ubiquitination	TGRMFDGKFVVATFY HCCCCCCEEEEEEEC	36.51	-
410	Ubiquitination	FYPLSAYKRGYLYQT ECCHHHHHCCCHHHH	38.78	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UHMK1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UHMK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UHMK1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of UHMK1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.