| UniProt ID | MOT10_HUMAN | |
|---|---|---|
| UniProt AC | Q8TF71 | |
| Protein Name | Monocarboxylate transporter 10 | |
| Gene Name | SLC16A10 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 515 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Basolateral cell membrane. |
|
| Protein Description | Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).. | |
| Protein Sequence | MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVELAGPATAEPHEPPEPPEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFIPWIHSKKQREISKTTGKEKMEKMLENQNSLLSSSSGMFKKESDSII | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MVLSQEEPDSA ----CCCCCCCCCCC | 24.92 | 30108239 | |
| 15 | Phosphorylation | PDSARGTSEAQPLGP CCCCCCCCCCCCCCC | 33.49 | - | |
| 36 | Phosphorylation | PPPGPGPSDSPEAAV CCCCCCCCCCHHHHH | 57.55 | 28348404 | |
| 38 | Phosphorylation | PGPGPSDSPEAAVEK CCCCCCCCHHHHHEE | 29.04 | 28985074 | |
| 97 | Phosphorylation | ACGVLFVSMLETFGS HHHHHHHHHHHHCCC | 15.43 | 25332170 | |
| 233 | Phosphorylation | DSVGLFYTLRVLCIF HHHHHHHHHHHHHHH | 10.76 | 24719451 | |
| 257 | Phosphorylation | TYRPLATSTKDKESG CCCCCCCCCCCCCCC | 28.05 | 30576142 | |
| 258 | Phosphorylation | YRPLATSTKDKESGG CCCCCCCCCCCCCCC | 38.62 | 30576142 | |
| 263 | Phosphorylation | TSTKDKESGGSGSSL CCCCCCCCCCCCCCH | 54.95 | 30108239 | |
| 266 | Phosphorylation | KDKESGGSGSSLFSR CCCCCCCCCCCHHCC | 38.74 | 23911959 | |
| 268 | Ubiquitination | KESGGSGSSLFSRKK CCCCCCCCCHHCCCC | 26.09 | 21890473 | |
| 268 | Phosphorylation | KESGGSGSSLFSRKK CCCCCCCCCHHCCCC | 26.09 | 30108239 | |
| 269 | Ubiquitination | ESGGSGSSLFSRKKF CCCCCCCCHHCCCCC | 36.64 | 22817900 | |
| 269 | Phosphorylation | ESGGSGSSLFSRKKF CCCCCCCCHHCCCCC | 36.64 | 23911959 | |
| 272 | Phosphorylation | GSGSSLFSRKKFSPP CCCCCHHCCCCCCCC | 48.78 | 30108239 | |
| 338 | Phosphorylation | VLMCIGVTSGVGRLL EEEHHCCCCHHHHHH | 17.98 | - | |
| 339 | Phosphorylation | LMCIGVTSGVGRLLF EEHHCCCCHHHHHHH | 29.13 | - | |
| 498 | Phosphorylation | KMLENQNSLLSSSSG HHHHHHHHHHHCCCC | 22.41 | 19413330 | |
| 501 | Phosphorylation | ENQNSLLSSSSGMFK HHHHHHHHCCCCCCC | 33.20 | 28348404 | |
| 502 | Phosphorylation | NQNSLLSSSSGMFKK HHHHHHHCCCCCCCC | 28.61 | 30108239 | |
| 503 | Phosphorylation | QNSLLSSSSGMFKKE HHHHHHCCCCCCCCC | 27.77 | 23401153 | |
| 504 | Phosphorylation | NSLLSSSSGMFKKES HHHHHCCCCCCCCCC | 35.90 | 21082442 | |
| 508 | Ubiquitination | SSSSGMFKKESDSII HCCCCCCCCCCCCCC | 46.90 | 22817900 | |
| 509 | Ubiquitination | SSSGMFKKESDSII- CCCCCCCCCCCCCC- | 51.70 | 22817900 | |
| 511 | Phosphorylation | SGMFKKESDSII--- CCCCCCCCCCCC--- | 45.60 | 29449344 | |
| 513 | Phosphorylation | MFKKESDSII----- CCCCCCCCCC----- | 31.31 | 29449344 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MOT10_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MOT10_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MOT10_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MOT10_HUMAN !! | ||||
| Kegg Disease | |
|---|---|
| There are no disease associations of PTM sites. | |
| OMIM Disease | |
| There are no disease associations of PTM sites. | |
| Kegg Drug | |
| There are no disease associations of PTM sites. | |
| DrugBank | |
| DB06262 | Droxidopa |
| DB00145 | Glycine |
| DB00160 | L-Alanine |
| DB00125 | L-Arginine |
| DB00174 | L-Asparagine |
| DB00128 | L-Aspartic Acid |
| DB00151 | L-Cysteine |
| DB00138 | L-Cystine |
| DB01235 | L-DOPA |
| DB00130 | L-Glutamine |
| DB00117 | L-Histidine |
| DB00167 | L-Isoleucine |
| DB00149 | L-Leucine |
| DB00123 | L-Lysine |
| DB00134 | L-Methionine |
| DB00120 | L-Phenylalanine |
| DB00172 | L-Proline |
| DB00133 | L-Serine |
| DB00156 | L-Threonine |
| DB00150 | L-Tryptophan |
| DB00135 | L-Tyrosine |
| DB00161 | L-Valine |
| DB00279 | Liothyronine |
| DB01583 | Liotrix |
| DB00119 | Pyruvic acid |
loading...
| Phosphorylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266 AND SER-269, ANDMASS SPECTROMETRY. | |
