CYH3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CYH3_HUMAN
• UniProt AC: O43739
• Protein Name: Cytohesin-3
• Gene Name: CYTH3 {ECO:0000312|HGNC:HGNC:9504}
• Organism: Homo sapiens (Human).
• Sequence Length: 400
• Subcellular Localization: Cytoplasm, cytosol. Cell membrane ; Peripheral membrane protein . Cell junction, adherens junction . Cell junction, tight junction . Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate.
• Protein Description: Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Play a role in the epithelial polarization (By similarity)..
• Protein Sequence: MDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Ubiquitination	LLDIRRRKKELIDDI HHHHHHHHHHHHHHH	49.11	29967540
32	Ubiquitination	LDIRRRKKELIDDIE HHHHHHHHHHHHHHH	56.81	29967540
43	Phosphorylation	DDIERLKYEIAEVMT HHHHHHHHHHHHHHH	19.70	27642862
62	Ubiquitination	LTSVEESKTTQRNKQ CCCHHHHHHHHHHHH	59.89	32015554
164	Ubiquitination	RLPGEAQKIDRMMEA CCCCHHHHHHHHHHH	54.33	24816145
240	Phosphorylation	EELLRNLYESIKNEP HHHHHHHHHHHHCCC	15.92	27067055
242	Phosphorylation	LLRNLYESIKNEPFK HHHHHHHHHHCCCCC	25.88	27067055
244	Ubiquitination	RNLYESIKNEPFKIP HHHHHHHHCCCCCCC	65.62	29967540
249	Ubiquitination	SIKNEPFKIPEDDGN HHHCCCCCCCCCCCC	68.98	29967540
259	Phosphorylation	EDDGNDLTHTFFNPD CCCCCCCCCCCCCCC	23.02	27067055
261	Phosphorylation	DGNDLTHTFFNPDRE CCCCCCCCCCCCCCC	25.37	27067055
273	Acetylation	DREGWLLKLGGGRVK CCCCEEEEECCCCCC	42.80	25953088
273	Ubiquitination	DREGWLLKLGGGRVK CCCCEEEEECCCCCC	42.80	29967540
280	Phosphorylation	KLGGGRVKTWKRRWF EECCCCCCEEEEEEE	47.51	24719451
281	Phosphorylation	LGGGRVKTWKRRWFI ECCCCCCEEEEEEEE	33.10	24719451
358	Phosphorylation	VVEGNHVVYRISAPS EEECCEEEEEEECCC	1.75	24719451
359	Phosphorylation	VEGNHVVYRISAPSP EECCEEEEEEECCCH	10.92	24719451
361	Phosphorylation	GNHVVYRISAPSPEE CCEEEEEEECCCHHH	1.95	24719451
362	Phosphorylation	NHVVYRISAPSPEEK CEEEEEEECCCHHHH	25.73	24719451
374	Phosphorylation	EEKEEWMKSIKASIS HHHHHHHHHHHHHHH	50.53	27251275
375	Phosphorylation	EKEEWMKSIKASISR HHHHHHHHHHHHHHC	17.14	27251275
385	Phosphorylation	ASISRDPFYDMLATR HHHHCCCHHHHHHHH	10.66	27251275
386	Phosphorylation	SISRDPFYDMLATRK HHHCCCHHHHHHHHH	13.06	21945579
390	Phosphorylation	DPFYDMLATRKRRIA CCHHHHHHHHHHHHH	9.95	27251275
391	Phosphorylation	PFYDMLATRKRRIAN CHHHHHHHHHHHHHC	32.53	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CYH3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CYH3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CYH3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CNKR1_HUMAN	CNKSR1	physical	16189514
CACO1_HUMAN	CALCOCO1	physical	16189514
GNAQ_HUMAN	GNAQ	physical	17846866
CNKR1_HUMAN	CNKSR1	physical	25416956
CC120_HUMAN	CCDC120	physical	25416956
SYCE1_HUMAN	SYCE1	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.