CYH2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CYH2_HUMAN
• UniProt AC: Q99418
• Protein Name: Cytohesin-2
• Gene Name: CYTH2 {ECO:0000312|HGNC:HGNC:9502}
• Organism: Homo sapiens (Human).
• Sequence Length: 400
• Subcellular Localization: Cell membrane ; Peripheral membrane protein . Cytoplasm . Cell projection . Cell projection, growth cone . Cell junction, tight junction . Cell junction, adherens junction . Both isoform 1 and isoform 2 are recruited to the cell membrane through its
• Protein Description: Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. [PubMed: 17398095 Involved in neurite growth (By similarity]
• Protein Sequence: MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Ubiquitination	LENIRRRKQELLVEI HHHHHHHHHHHHHHH	46.44	-
45	Phosphorylation	EELSEAMSEVEGLEA HHHHHHHHHHHCHHC	45.60	28060719
56	Phosphorylation	GLEANEGSKTLQRNR CHHCCCHHHHHHHHH	19.11	28060719
57	Ubiquitination	LEANEGSKTLQRNRK HHCCCHHHHHHHHHH	65.20	-
58	Phosphorylation	EANEGSKTLQRNRKM HCCCHHHHHHHHHHH	29.80	27422710
70	Ubiquitination	RKMAMGRKKFNMDPK HHHHHCCHHCCCCHH	56.86	-
71	Ubiquitination	KMAMGRKKFNMDPKK HHHHCCHHCCCCHHH	40.38	-
78	Ubiquitination	KFNMDPKKGIQFLVE HCCCCHHHCHHHHHH	67.64	29967540
92	Phosphorylation	ENELLQNTPEEIARF HCHHHCCCHHHHHHH	21.08	27050516
101	Phosphorylation	EEIARFLYKGEGLNK HHHHHHHHCCCCCCH	17.78	27050516
102	Ubiquitination	EIARFLYKGEGLNKT HHHHHHHCCCCCCHH	53.27	23000965
108	Ubiquitination	YKGEGLNKTAIGDYL HCCCCCCHHHCHHHH	44.36	23000965
124	Ubiquitination	EREELNLAVLHAFVD CHHHHHHHHHHHHCC	10.76	23000965
130	Ubiquitination	LAVLHAFVDLHEFTD HHHHHHHCCHHHCCC	8.75	23000965
159	Ubiquitination	RLPGEAQKIDRMMEA CCCCHHHHHHHHHHH	54.33	24816145
181	Ubiquitination	CNPGVFQSTDTCYVL CCCCCCCCCCHHHHH	19.45	24816145
235	Phosphorylation	EELLRNLYDSIRNEP HHHHHHHHHHHHCCC	15.93	-
244	Ubiquitination	SIRNEPFKIPEDDGN HHHCCCCCCCCCCCC	68.98	29967540
268	Ubiquitination	DREGWLLKLGGGRVK CCCCEEEEECCCCCC	42.80	29967540
276	Phosphorylation	LGGGRVKTWKRRWFI ECCCCCCEEEEEEEE	33.10	24719451
319	Ubiquitination	REVDDPRKPNCFELY EECCCCCCCCEEEEE	46.07	-
340	Phosphorylation	QLIKACKTEADGRVV CEEHHEEECCCCCEE	35.97	26074081
354	Phosphorylation	VEGNHMVYRISAPTQ EECCEEEEEEECCCH	8.48	26074081
360	Phosphorylation	VYRISAPTQEEKDEW EEEEECCCHHHHHHH	48.61	-
363	Ubiquitination	ISAPTQEEKDEWIKS EECCCHHHHHHHHHH	56.86	29967540
364	Ubiquitination	SAPTQEEKDEWIKSI ECCCHHHHHHHHHHH	61.26	29967540
369	Ubiquitination	EEKDEWIKSIQAAVS HHHHHHHHHHHHHHC	42.45	-
381	Phosphorylation	AVSVDPFYEMLAARK HHCCCHHHHHHHHHH	13.05	21945579
392	Phosphorylation	AARKKRISVKKKQEQ HHHHHCCCCCCCCCC	31.73	10531036

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
276	T	Phosphorylation	Kinase	AKT1	P31749	PSP
392	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
392	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
392	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CYH2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CYH2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CC120_HUMAN	CCDC120	physical	16189514
ICEF1_HUMAN	IPCEF1	physical	12920129
ARF3_YEAST	ARF3	physical	17786213
ARRB1_HUMAN	ARRB1	physical	11533043
ARRB2_HUMAN	ARRB2	physical	11533043
ARF6_HUMAN	ARF6	physical	9417041
ARF1_HUMAN	ARF1	physical	9417041
ARF6_HUMAN	ARF6	physical	18094045
PLPL2_HUMAN	PNPLA2	physical	21789191
GNAQ_HUMAN	GNAQ	physical	16650966
ARF6_HUMAN	ARF6	physical	17846866
CC120_HUMAN	CCDC120	physical	25416956
AA2AR_HUMAN	ADORA2A	physical	16027149
ICEF1_RAT	Ipcef1	physical	15923660
ARL4D_HUMAN	ARL4D	physical	17804820
ARL4A_HUMAN	ARL4A	physical	17804820

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.