ARL4D_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARL4D_HUMAN
• UniProt AC: P49703
• Protein Name: ADP-ribosylation factor-like protein 4D
• Gene Name: ARL4D
• Organism: Homo sapiens (Human).
• Sequence Length: 201
• Subcellular Localization: Nucleus, nucleolus. Cell membrane . Nucleus . Cytoplasm .
• Protein Description: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form..
• Protein Sequence: MGNHLTEMAPTASSFLPHFQALHVVVIGLDSAGKTSLLYRLKFKEFVQSVPTKGFNTEKIRVPLGGSRGITFQVWDVGGQEKLRPLWRSYTRRTDGLVFVVDAAEAERLEEAKVELHRISRASDNQGVPVLVLANKQDQPGALSAAEVEKRLAVRELAAATLTHVQGCSAVDGLGLQQGLERLYEMILKRKKAARGGKKRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGNHLTEMA ------CCCCHHHCC	30.20	-
42	Ubiquitination	TSLLYRLKFKEFVQS CHHHHHHHHHHHHHH	45.45	22817900
44	Ubiquitination	LLYRLKFKEFVQSVP HHHHHHHHHHHHHCC	48.97	21906983
53	Ubiquitination	FVQSVPTKGFNTEKI HHHHCCCCCCCCCEE	56.27	29967540
59	Ubiquitination	TKGFNTEKIRVPLGG CCCCCCCEEEEECCC	33.50	29967540
113	Ubiquitination	AERLEEAKVELHRIS HHHHHHHHHHHHHHH	39.25	29967540
123	Phosphorylation	LHRISRASDNQGVPV HHHHHCCCCCCCCCE	35.66	-
136	Ubiquitination	PVLVLANKQDQPGAL CEEEEECCCCCCCCC	50.04	29967540
144	Phosphorylation	QDQPGALSAAEVEKR CCCCCCCCHHHHHHH	25.54	25072903
150	Ubiquitination	LSAAEVEKRLAVREL CCHHHHHHHHHHHHH	58.86	21906983
189	Ubiquitination	RLYEMILKRKKAARG HHHHHHHHHHHHHCC	51.77	21906983
191	Ubiquitination	YEMILKRKKAARGGK HHHHHHHHHHHCCCC	45.22	22817900
192	Ubiquitination	EMILKRKKAARGGKK HHHHHHHHHHCCCCC	51.84	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARL4D_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARL4D_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARL4D_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNJA1_HUMAN	DNAJA1	physical	16169070
EMAL4_HUMAN	EML4	physical	16169070
JIP3_HUMAN	MAPK8IP3	physical	16169070
NDRG1_HUMAN	NDRG1	physical	16169070
PGAM1_HUMAN	PGAM1	physical	16169070
GLU2B_HUMAN	PRKCSH	physical	16169070
SYEP_HUMAN	EPRS	physical	16169070
RSMN_HUMAN	SNRPN	physical	16169070
EI2BA_HUMAN	EIF2B1	physical	16169070
TLE1_HUMAN	TLE1	physical	16169070
UBR1_HUMAN	UBR1	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
A4_HUMAN	APP	physical	21832049
C102B_HUMAN	CCDC102B	physical	25416956
TERF2_HUMAN	TERF2	physical	28514442
TBA3C_HUMAN	TUBA3C	physical	28514442
TE2IP_HUMAN	TERF2IP	physical	28514442
GILT_HUMAN	IFI30	physical	28514442
CYH2_HUMAN	CYTH2	physical	17804820
ARF6_HUMAN	ARF6	physical	17804820

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.