dbPTM

ICEF1_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ICEF1_RAT
UniProt AC	Q80VL0
Protein Name	Interactor protein for cytohesin exchange factors 1
Gene Name	Ipcef1
Organism	Rattus norvegicus (Rat).
Sequence Length	406
Subcellular Localization	Cytoplasm . Cell membrane . Translocated with PSCD2 to the plasma membrane upon epidermal growth factor (EGF) stimulation.
Protein Description	Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner..
Protein Sequence	MSRRRISCKDLGHADCQGWLYKKKEKGTFLSNKWKKFWVVLKGSSLYWYGNQLAEKADGFVNLPDFTVERASECKKKNAFKINHPQIKTFYFAAENLQEMNMWLNKLGFAVTHKESTTKDEECYSESEQEDPETAVEAPPPPSASATSSPVAARRASSSSPKRRETSCSFSSLENTVKAPSRFSSSGSKERQSWLDIVNSSPATEDVGHPLSFAVQVHTLASSEASSCRVSENSSTTPESGCLNSLSSDDTSSLNNSQDHLTVPDRASGSRMTDRDEIKSSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQVPQDPEVTPQEIMNPTSSDCVENSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
157	Phosphorylation	PVAARRASSSSPKRR HHHHHHCCCCCCCCC	29.01	25403869
167	Phosphorylation	SPKRRETSCSFSSLE CCCCCCCCCCHHHHH	11.74	22108457
169	Phosphorylation	KRRETSCSFSSLENT CCCCCCCCHHHHHCC	28.12	22108457
188	Phosphorylation	SRFSSSGSKERQSWL CCCCCCCCHHHHHHH	33.04	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ICEF1_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ICEF1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ICEF1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ICEF1_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ICEF1_RAT

Related Literatures of Post-Translational Modification