ICEF1_HUMAN - dbPTM
ICEF1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ICEF1_HUMAN
UniProt AC Q8WWN9
Protein Name Interactor protein for cytohesin exchange factors 1
Gene Name IPCEF1
Organism Homo sapiens (Human).
Sequence Length 437
Subcellular Localization Cytoplasm. Cell membrane. Translocated with PSCD2 to the plasma membrane upon epidermal growth factor (EGF) stimulation..
Protein Description Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner..
Protein Sequence MTSYMAIDGSALVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIMDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDDTPQELKKSPSSPSVENSI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTSYMAIDG
------CCCEEEECC		28.6824043423
3Phosphorylation-----MTSYMAIDGS
-----CCCEEEECCC		16.1824043423
4Phosphorylation----MTSYMAIDGSA
----CCCEEEECCCE		4.9629759185
10PhosphorylationSYMAIDGSALVPLRQ
CEEEECCCEEEECCC		18.0624043423
23PhosphorylationRQKPRRKTQGFLTMS
CCCCCCCCCCEEEEE		31.92-
28PhosphorylationRKTQGFLTMSRRRIS
CCCCCEEEEECCCEE		15.73-
30PhosphorylationTQGFLTMSRRRISCK
CCCEEEEECCCEEHH		19.8730631047
56PhosphorylationYKKKEKGSFLSNKWK
EEECCCCCCCCCCCC		33.8030108239
75PhosphorylationILKGSSLYWYSNQMA
EEECCCEEEECHHHH		12.30-
206PhosphorylationSLENTVKTPSSFPSS
CCCCCCCCCCCCCCC		24.8623312004
208PhosphorylationENTVKTPSSFPSSLS
CCCCCCCCCCCCCCC		50.2530108239
209PhosphorylationNTVKTPSSFPSSLSK
CCCCCCCCCCCCCCH		42.2428450419
210PhosphorylationTVKTPSSFPSSLSKE
CCCCCCCCCCCCCHH		8.8027251275
212PhosphorylationKTPSSFPSSLSKERQ
CCCCCCCCCCCHHHH		41.7328450419
213PhosphorylationTPSSFPSSLSKERQS
CCCCCCCCCCHHHHC		36.5828450419
215PhosphorylationSSFPSSLSKERQSLP
CCCCCCCCHHHHCCC		34.1228450419
220PhosphorylationSLSKERQSLPDTVNS
CCCHHHHCCCCHHHH		48.3628348404
224PhosphorylationERQSLPDTVNSLSAA
HHHCCCCHHHHCHHH		21.4628348404
225PhosphorylationRQSLPDTVNSLSAAE
HHCCCCHHHHCHHHH		6.2927251275
227PhosphorylationSLPDTVNSLSAAEDE
CCCCHHHHCHHHHHC		21.2628348404
229PhosphorylationPDTVNSLSAAEDEGQ
CCHHHHCHHHHHCCC		25.8327251275
239PhosphorylationEDEGQPITFAVQVHS
HHCCCCCEEEEEECC		16.5430108239
246PhosphorylationTFAVQVHSPVPSEAG
EEEEEECCCCCCCCC		28.8330108239
247PhosphorylationFAVQVHSPVPSEAGI
EEEEECCCCCCCCCH		27.4527251275
250PhosphorylationQVHSPVPSEAGIHKA
EECCCCCCCCCHHHH		40.0730108239
305PhosphorylationKIMDKEETKVSEDDE
CCCCHHHHCCCCHHH		37.5330108239
306PhosphorylationIMDKEETKVSEDDEM
CCCHHHHCCCCHHHH		47.2227251275
308PhosphorylationDKEETKVSEDDEMEK
CHHHHCCCCHHHHHH		36.5430108239
317PhosphorylationDDEMEKLYKSLEQAS
HHHHHHHHHHHHHHC		15.0329978859
319PhosphorylationEMEKLYKSLEQASLS
HHHHHHHHHHHHCCC		24.4725278378
324PhosphorylationYKSLEQASLSPLGDR
HHHHHHHCCCCCCCC		29.1328450419
326PhosphorylationSLEQASLSPLGDRRP
HHHHHCCCCCCCCCC		18.6423401153
334PhosphorylationPLGDRRPSTKKELRK
CCCCCCCCCHHHHHH		51.5523882029
335PhosphorylationLGDRRPSTKKELRKS
CCCCCCCCHHHHHHH		49.1430576142
336PhosphorylationGDRRPSTKKELRKSF
CCCCCCCHHHHHHHH		48.8924719451
342PhosphorylationTKKELRKSFVKRCKN
CHHHHHHHHHHHCCC		28.9223401153
398PhosphorylationREWKVMNTLLIQDIY
HHHHHHHHHHHHHHH		12.5822617229
405PhosphorylationTLLIQDIYQQQRASP
HHHHHHHHHHHCCCC		14.4628450419
411PhosphorylationIYQQQRASPAPDDTD
HHHHHCCCCCCCCCC		24.6323401153
412PhosphorylationYQQQRASPAPDDTDD
HHHHCCCCCCCCCCC		46.9924719451
417PhosphorylationASPAPDDTDDTPQEL
CCCCCCCCCCCHHHH		43.0623684312
420PhosphorylationAPDDTDDTPQELKKS
CCCCCCCCHHHHHHC		29.6723684312
427PhosphorylationTPQELKKSPSSPSVE
CHHHHHHCCCCCCCC		28.5520164059
429PhosphorylationQELKKSPSSPSVENS
HHHHHCCCCCCCCCC		63.0720164059
430PhosphorylationELKKSPSSPSVENSI
HHHHCCCCCCCCCCC		25.2823401153
431PhosphorylationLKKSPSSPSVENSI-
HHHCCCCCCCCCCC-		46.8927251275
432PhosphorylationKKSPSSPSVENSI--
HHCCCCCCCCCCC--		43.9728450419
436PhosphorylationSSPSVENSI------
CCCCCCCCC------		19.0328450419
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ICEF1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ICEF1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ICEF1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CYH2_HUMANCYTH2physical
12920129
CYH1_HUMANCYTH1physical
12920129
CYH3_HUMANCYTH3physical
12920129
CYH4_HUMANCYTH4physical
12920129
CYH1_HUMANCYTH1physical
28514442
CYH2_HUMANCYTH2physical
28514442
CYH3_HUMANCYTH3physical
28514442
TRI11_HUMANTRIM11physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ICEF1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411, AND MASSSPECTROMETRY.

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