UniProt ID | ICEF1_HUMAN | |
---|---|---|
UniProt AC | Q8WWN9 | |
Protein Name | Interactor protein for cytohesin exchange factors 1 | |
Gene Name | IPCEF1 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 437 | |
Subcellular Localization | Cytoplasm. Cell membrane. Translocated with PSCD2 to the plasma membrane upon epidermal growth factor (EGF) stimulation.. | |
Protein Description | Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner.. | |
Protein Sequence | MTSYMAIDGSALVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIMDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDDTPQELKKSPSSPSVENSI | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
|
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Phosphorylation | ------MTSYMAIDG ------CCCEEEECC | 28.68 | 24043423 | |
3 | Phosphorylation | -----MTSYMAIDGS -----CCCEEEECCC | 16.18 | 24043423 | |
4 | Phosphorylation | ----MTSYMAIDGSA ----CCCEEEECCCE | 4.96 | 29759185 | |
10 | Phosphorylation | SYMAIDGSALVPLRQ CEEEECCCEEEECCC | 18.06 | 24043423 | |
23 | Phosphorylation | RQKPRRKTQGFLTMS CCCCCCCCCCEEEEE | 31.92 | - | |
28 | Phosphorylation | RKTQGFLTMSRRRIS CCCCCEEEEECCCEE | 15.73 | - | |
30 | Phosphorylation | TQGFLTMSRRRISCK CCCEEEEECCCEEHH | 19.87 | 30631047 | |
56 | Phosphorylation | YKKKEKGSFLSNKWK EEECCCCCCCCCCCC | 33.80 | 30108239 | |
75 | Phosphorylation | ILKGSSLYWYSNQMA EEECCCEEEECHHHH | 12.30 | - | |
206 | Phosphorylation | SLENTVKTPSSFPSS CCCCCCCCCCCCCCC | 24.86 | 23312004 | |
208 | Phosphorylation | ENTVKTPSSFPSSLS CCCCCCCCCCCCCCC | 50.25 | 30108239 | |
209 | Phosphorylation | NTVKTPSSFPSSLSK CCCCCCCCCCCCCCH | 42.24 | 28450419 | |
210 | Phosphorylation | TVKTPSSFPSSLSKE CCCCCCCCCCCCCHH | 8.80 | 27251275 | |
212 | Phosphorylation | KTPSSFPSSLSKERQ CCCCCCCCCCCHHHH | 41.73 | 28450419 | |
213 | Phosphorylation | TPSSFPSSLSKERQS CCCCCCCCCCHHHHC | 36.58 | 28450419 | |
215 | Phosphorylation | SSFPSSLSKERQSLP CCCCCCCCHHHHCCC | 34.12 | 28450419 | |
220 | Phosphorylation | SLSKERQSLPDTVNS CCCHHHHCCCCHHHH | 48.36 | 28348404 | |
224 | Phosphorylation | ERQSLPDTVNSLSAA HHHCCCCHHHHCHHH | 21.46 | 28348404 | |
225 | Phosphorylation | RQSLPDTVNSLSAAE HHCCCCHHHHCHHHH | 6.29 | 27251275 | |
227 | Phosphorylation | SLPDTVNSLSAAEDE CCCCHHHHCHHHHHC | 21.26 | 28348404 | |
229 | Phosphorylation | PDTVNSLSAAEDEGQ CCHHHHCHHHHHCCC | 25.83 | 27251275 | |
239 | Phosphorylation | EDEGQPITFAVQVHS HHCCCCCEEEEEECC | 16.54 | 30108239 | |
246 | Phosphorylation | TFAVQVHSPVPSEAG EEEEEECCCCCCCCC | 28.83 | 30108239 | |
247 | Phosphorylation | FAVQVHSPVPSEAGI EEEEECCCCCCCCCH | 27.45 | 27251275 | |
250 | Phosphorylation | QVHSPVPSEAGIHKA EECCCCCCCCCHHHH | 40.07 | 30108239 | |
305 | Phosphorylation | KIMDKEETKVSEDDE CCCCHHHHCCCCHHH | 37.53 | 30108239 | |
306 | Phosphorylation | IMDKEETKVSEDDEM CCCHHHHCCCCHHHH | 47.22 | 27251275 | |
308 | Phosphorylation | DKEETKVSEDDEMEK CHHHHCCCCHHHHHH | 36.54 | 30108239 | |
317 | Phosphorylation | DDEMEKLYKSLEQAS HHHHHHHHHHHHHHC | 15.03 | 29978859 | |
319 | Phosphorylation | EMEKLYKSLEQASLS HHHHHHHHHHHHCCC | 24.47 | 25278378 | |
324 | Phosphorylation | YKSLEQASLSPLGDR HHHHHHHCCCCCCCC | 29.13 | 28450419 | |
326 | Phosphorylation | SLEQASLSPLGDRRP HHHHHCCCCCCCCCC | 18.64 | 23401153 | |
334 | Phosphorylation | PLGDRRPSTKKELRK CCCCCCCCCHHHHHH | 51.55 | 23882029 | |
335 | Phosphorylation | LGDRRPSTKKELRKS CCCCCCCCHHHHHHH | 49.14 | 30576142 | |
336 | Phosphorylation | GDRRPSTKKELRKSF CCCCCCCHHHHHHHH | 48.89 | 24719451 | |
342 | Phosphorylation | TKKELRKSFVKRCKN CHHHHHHHHHHHCCC | 28.92 | 23401153 | |
398 | Phosphorylation | REWKVMNTLLIQDIY HHHHHHHHHHHHHHH | 12.58 | 22617229 | |
405 | Phosphorylation | TLLIQDIYQQQRASP HHHHHHHHHHHCCCC | 14.46 | 28450419 | |
411 | Phosphorylation | IYQQQRASPAPDDTD HHHHHCCCCCCCCCC | 24.63 | 23401153 | |
412 | Phosphorylation | YQQQRASPAPDDTDD HHHHCCCCCCCCCCC | 46.99 | 24719451 | |
417 | Phosphorylation | ASPAPDDTDDTPQEL CCCCCCCCCCCHHHH | 43.06 | 23684312 | |
420 | Phosphorylation | APDDTDDTPQELKKS CCCCCCCCHHHHHHC | 29.67 | 23684312 | |
427 | Phosphorylation | TPQELKKSPSSPSVE CHHHHHHCCCCCCCC | 28.55 | 20164059 | |
429 | Phosphorylation | QELKKSPSSPSVENS HHHHHCCCCCCCCCC | 63.07 | 20164059 | |
430 | Phosphorylation | ELKKSPSSPSVENSI HHHHCCCCCCCCCCC | 25.28 | 23401153 | |
431 | Phosphorylation | LKKSPSSPSVENSI- HHHCCCCCCCCCCC- | 46.89 | 27251275 | |
432 | Phosphorylation | KKSPSSPSVENSI-- HHCCCCCCCCCCC-- | 43.97 | 28450419 | |
436 | Phosphorylation | SSPSVENSI------ CCCCCCCCC------ | 19.03 | 28450419 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ICEF1_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ICEF1_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ICEF1_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
CYH2_HUMAN | CYTH2 | physical | 12920129 | |
CYH1_HUMAN | CYTH1 | physical | 12920129 | |
CYH3_HUMAN | CYTH3 | physical | 12920129 | |
CYH4_HUMAN | CYTH4 | physical | 12920129 | |
CYH1_HUMAN | CYTH1 | physical | 28514442 | |
CYH2_HUMAN | CYTH2 | physical | 28514442 | |
CYH3_HUMAN | CYTH3 | physical | 28514442 | |
TRI11_HUMAN | TRIM11 | physical | 28514442 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411, AND MASSSPECTROMETRY. |