CYH4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CYH4_HUMAN
• UniProt AC: Q9UIA0
• Protein Name: Cytohesin-4
• Gene Name: CYTH4
• Organism: Homo sapiens (Human).
• Sequence Length: 394
• Subcellular Localization: Cell membrane ; Peripheral membrane protein .
• Protein Description: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP..
• Protein Sequence: MDLCHPEPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASITRVPFYDLVSTRKKKIASKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	HPEPAELSSGETEEL CCCCCCCCCCCHHHH	28.00	28450419
13	Phosphorylation	PEPAELSSGETEELQ CCCCCCCCCCHHHHH	53.96	28450419
16	Phosphorylation	AELSSGETEELQRIK CCCCCCCHHHHHHHH	37.98	28450419
102	Ubiquitination	DIARFLYKGEGLNKT HHHHHHHCCCCCCCH	53.27	-
109	Phosphorylation	KGEGLNKTAIGTYLG CCCCCCCHHHHHHCC	23.57	24719451
114	Phosphorylation	NKTAIGTYLGERDPI CCHHHHHHCCCCCCC	13.90	24719451
159	Ubiquitination	RLPGEAQKIDRMMEA CCCCHHHHHHHHHHH	54.33	-
215	Phosphorylation	PPFERFVSMNRGINN CCHHHHHCCCCCCCC	13.97	23532336
268	Ubiquitination	DREGWLLKLGGRVKT CCCEEEEEECCEECE	42.80	-
275	Phosphorylation	KLGGRVKTWKRRWFI EECCEECEEEEEEEE	33.10	24719451
356	Phosphorylation	KHESYRISATSAEER CCCEEEEECCCHHHH	19.25	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CYH4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CYH4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CYH4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AMOL2_HUMAN	AMOTL2	physical	25416956
TRI54_HUMAN	TRIM54	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, AND MASSSPECTROMETRY.
PubMed: 15302935