ARL4A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARL4A_HUMAN
• UniProt AC: P40617
• Protein Name: ADP-ribosylation factor-like protein 4A
• Gene Name: ARL4A
• Organism: Homo sapiens (Human).
• Sequence Length: 200
• Subcellular Localization: Cell membrane. Cytoplasm. Nucleus, nucleolus. Localization in the nucleolus is dependent by nucleotide binding.
• Protein Description: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form..
• Protein Sequence: MGNGLSDQTSILSNLPSFQSFHIVILGLDCAGKTTVLYRLQFNEFVNTVPTKGFNTEKIKVTLGNSKTVTFHFWDVGGQEKLRPLWKSYTRCTDGIVFVVDSVDVERMEEAKTELHKITRISENQGVPVLIVANKQDLRNSLSLSEIEKLLAMGELSSSTPWHLQPTCAIIGDGLKEGLEKLHDMIIKRRKMLRQQKKKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGNGLSDQT ------CCCCCCCHH	36.59	-
58	Ubiquitination	TKGFNTEKIKVTLGN CCCCCCCEEEEEECC	45.87	-
113	Phosphorylation	ERMEEAKTELHKITR HHHHHHHHHHHHHHH	51.32	-
117	Ubiquitination	EAKTELHKITRISEN HHHHHHHHHHHCCCC	59.40	-
135	Ubiquitination	PVLIVANKQDLRNSL CEEEEECHHHHHHCC	35.14	21906983
141	Phosphorylation	NKQDLRNSLSLSEIE CHHHHHHCCCHHHHH	16.95	29978859
143	Phosphorylation	QDLRNSLSLSEIEKL HHHHHCCCHHHHHHH	29.66	29978859
145	Phosphorylation	LRNSLSLSEIEKLLA HHHCCCHHHHHHHHH	32.90	30622161
181	Acetylation	GLKEGLEKLHDMIIK HHHHHHHHHHHHHHH	57.05	18604399
188	Ubiquitination	KLHDMIIKRRKMLRQ HHHHHHHHHHHHHHH	34.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARL4A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARL4A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARL4A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IMA1_HUMAN	KPNA2	physical	10980193
C102B_HUMAN	CCDC102B	physical	25416956
SPC1L_HUMAN	SPATC1L	physical	25416956
CCD57_HUMAN	CCDC57	physical	25416956
ELMO1_HUMAN	ELMO1	physical	21930703
RAC1_HUMAN	RAC1	physical	21930703

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.