AP1M1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AP1M1_MOUSE
• UniProt AC: P35585
• Protein Name: AP-1 complex subunit mu-1
• Gene Name: Ap1m1
• Organism: Mus musculus (Mouse).
• Sequence Length: 423
• Subcellular Localization: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
• Protein Description: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules..
• Protein Sequence: MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIEAVNLLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMVKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSVKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRTQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSASAVYVL ------CCCCEEEEE	30.82	-
12	Acetylation	AVYVLDLKGKVLICR EEEEEECCCCEEEEC	57.25	23954790
12	Succinylation	AVYVLDLKGKVLICR EEEEEECCCCEEEEC	57.25	23954790
144	Phosphorylation	QEGHKLETGAPRPPA HCCCCCCCCCCCCCC	49.43	25619855
152	Phosphorylation	GAPRPPATVTNAVSW CCCCCCCEEEHHCCC	33.37	25521595
154	Phosphorylation	PRPPATVTNAVSWRS CCCCCEEEHHCCCCC	17.07	25521595
158	Phosphorylation	ATVTNAVSWRSEGIK CEEEHHCCCCCCCCC	17.86	25619855
165	Malonylation	SWRSEGIKYRKNEVF CCCCCCCCCCCCCCH	50.27	26320211
165	Acetylation	SWRSEGIKYRKNEVF CCCCCCCCCCCCCCH	50.27	15618271
223	Phosphorylation	DKVLFDNTGRGKSKS CEEEECCCCCCCCCC	30.05	25521595
229	Malonylation	NTGRGKSKSVELEDV CCCCCCCCCEEHHHC	63.10	26320211
245	Phosphorylation	FHQCVRLSRFENDRT EEEEEEHHHCCCCCE	25.10	23140645
296	Phosphoglycerylation	SRIEYMVKAKSQFKR CCHHHHHHCHHHHCC	33.30	-
322	Phosphorylation	PVPNDADSPKFKTTV CCCCCCCCCCCCCEE	31.54	30635358
324	Acetylation	PNDADSPKFKTTVGS CCCCCCCCCCCEECE	64.54	23954790
326	Ubiquitination	DADSPKFKTTVGSVK CCCCCCCCCEECEEE	49.79	-
326	Malonylation	DADSPKFKTTVGSVK CCCCCCCCCEECEEE	49.79	26320211
384	Phosphorylation	SVKFEIPYFTTSGIQ EEEEEECEEECCCCE	21.15	20531401
386	Phosphorylation	KFEIPYFTTSGIQVR EEEECEEECCCCEEE	17.76	20531401
388	Phosphorylation	EIPYFTTSGIQVRYL EECEEECCCCEEEEE	30.73	25367039
396	Malonylation	GIQVRYLKIIEKSGY CCEEEEEEEHHHHCC	32.48	26320211
400	Ubiquitination	RYLKIIEKSGYQALP EEEEEHHHHCCCCCC	38.48	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AP1M1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AP1M1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AP1M1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AP1M1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-152 AND THR-154, ANDMASS SPECTROMETRY.
PubMed: 17242355