| UniProt ID | NAA25_MOUSE | |
|---|---|---|
| UniProt AC | Q8BWZ3 | |
| Protein Name | N-alpha-acetyltransferase 25, NatB auxiliary subunit | |
| Gene Name | Naa25 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 972 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.. | |
| Protein Sequence | MATRGHVQDPNDRRLRPIYDYLDNGNNKMAIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKNPYYFWSVMSLIMQSISARDENLSKTMFLPLAERMVEKMVKEDKIEAEAEVELYYMILERLGKYQEALDVIRGKLGEKLTSEIQSRENKCMAMYKKLSKWPECNALSRRLLLKNSDDWQFYLTYFDSVFRLIEEAWTPPAEGEHSLEGEVHCSAEDAVKFIEDRITEASQSSRHVRGPHLAKLELIRRLRSQGCNDEYKLGDPEELMFQYFKKFGDKPCCFTDLKVFVDLLPAAQCTQFINQLLGVVPLSTPTEDKLALPADIRGLQQHLCVVQLTRLLGLYHSMDKSQKLDVVKELMLRYQHGLEFGRSCLKTELQFSDYYCLLAVHVLIDVWREAGEETAVWQALTLLEEGLTHSPSNAQFKLLLVRIYCVLGAFEPVVDLYSSLDAKHIQHDTIGYLLTRYAASLGQYAAASQSCNFALRFFHSNQKDTSEYIIQAYKYGAFEKIPEFIAFRNRLNNSLHFAQVRTERMLLDLLLEANISISLAESIKSMNLRPEEDDVPWEDLRDNRDLDVFFSWDPKDRNVSEEHKKLSLEEETMWLRIRSLTLRLISGLPSLTHPVEPKNSEKMSENGVSSRIDILRLLLQQLEVAVETGKRFIEKEIQYPFLGPVPTRMGRFFSSGCCQCQVQSFHLVSDMYELDTSGLEGTVDIQERIENSLASLLELLKGVFSTCKGDLLEVTDGNVKTQPAVLENLVFFVETISVILWVSSYCESVLRPYKLNIQKKKKKKKETSIIMPPIFTSFQDYVTGLQTVISNAVDHIKGLEAHLIALRLEELTLEETSISTEERKFSKTVQGKVQSSYLHSLLETGELLRKRLETTKKLKI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 244 | Ubiquitination | AMYKKLSKWPECNAL HHHHHHHCCHHHCHH | 76.76 | - | |
| 327 | Ubiquitination | VRGPHLAKLELIRRL CCCHHHHHHHHHHHH | 49.18 | - | |
| 357 | Ubiquitination | ELMFQYFKKFGDKPC HHHHHHHHHHCCCCC | 42.11 | - | |
| 586 | Ubiquitination | EYIIQAYKYGAFEKI HHHHHHHHHCHHHCC | 39.98 | - | |
| 691 | Phosphorylation | TMWLRIRSLTLRLIS HHHHHHHHHHHHHHC | 24.28 | 26239621 | |
| 747 | Ubiquitination | TGKRFIEKEIQYPFL HCHHHHHHHCCCCCC | 56.13 | - | |
| 804 | Phosphorylation | IQERIENSLASLLEL HHHHHHHHHHHHHHH | 16.72 | - | |
| 928 | Phosphorylation | EELTLEETSISTEER HHHCCCCCCCCHHHH | 23.22 | 30635358 | |
| 929 | Phosphorylation | ELTLEETSISTEERK HHCCCCCCCCHHHHC | 20.16 | 30635358 | |
| 931 | Phosphorylation | TLEETSISTEERKFS CCCCCCCCHHHHCCH | 29.54 | 30635358 | |
| 932 | Phosphorylation | LEETSISTEERKFSK CCCCCCCHHHHCCHH | 39.95 | 30635358 | |
| 938 | Phosphorylation | STEERKFSKTVQGKV CHHHHCCHHHHCHHH | 30.38 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NAA25_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NAA25_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NAA25_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of NAA25_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-691, AND MASSSPECTROMETRY. | |
