TT21B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TT21B_MOUSE
• UniProt AC: Q0HA38
• Protein Name: Tetratricopeptide repeat protein 21B
• Gene Name: Ttc21b
• Organism: Mus musculus (Mouse).
• Sequence Length: 1315
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium axoneme . In polarized epithelial inner medullary collecting ducts cells and in the nodes of mice at 8.0 dpc, colocalizes with alpha-tubulin in cilia. Expressed in a punctate manner throughout the axoneme from the cili
• Protein Description: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Negatively modulates the SHH signal transduction..
• Protein Sequence: MDSQGLKTLINYYCQERYYHHVLLVASEGMKKYSSDPVFRFYHAYGTLMEGKAQEALREFEAIKNKQDVSLCSLMALMYVHKMSPNPDREAILELDTKMKEQRKEAGRKALYHAGLFLWHIGRHDKAREYIDRMSKMPHDSNEGPILKAWLDITRGKEPYAKKALRYFEEGLQDGNDIFALLGKVLCLEIRQNYSGALETVSQIIVNFPSFLPAFEKKMKLQLALQDWDQTVETAQRLLLQDNHNVEALRMLALYYLCREGDVEKAATKLENLGNALDVMEPQNAQLFYKITLAFSRTCGRNQLILQKVQSFLEKAFSLTPQQAEIATELGYQMILQGKVKEAWKWYRTAMTLNESNISAVTGLIRCQLIEGQLQDADQQLEFFSEFQQSMGKSAELMYLHAVLATKKNNRQDEVINLLNDVVNTHFSHLEDLPLGIQYFEKLNPDFLLEVVTEYLNLCPIQPAGPGQPLSPVLRRCSSVLETIIRSVPGLPQAVFLMAKVKYLSGDTEAAYNNLQHCLEHSPSYAEAHLLMAQVYLSQDKVKLCSQSLELCLSYNFNVREYPLYHLIKAQSQKKMGEVAEAIKTLHMAMNLPGMRRSRASSKSKHRTEVDASHRLSIFLELVEVHRLNGEQHEAAKVLQDAIHEFSGTCEELRVTIANADLALAQGDTDRALSMLRNVTTEQPYFIEAKEKMADIYLKHRKEKMLYITCYREIAERMPSPRSFLLLGDAYMNIQEPEEAIVAYEQALNQNPKDGTLARKIGKALVKTHNYSKAITYYEAALKSGQQNCLCYDLAELLLRLKLYEKAEKVLQHSLAHEPVSELSALMVDGRSQVLLAKVYSKMERPSDAIAALQQARELQARILKRVQMEQPDAVPSQKHFAAEICAEIAKHSAAQRDYEKAITFYREALVHCETDSKIMLELAQLYLAQEDLDASLRHCALLLQRDQDNEPATMLMADLMFRKQDYEQAVYHLQQLLDRKPDNFMTLSRLIDLLRRCGKLEDVPRFFLMAEKHNSRTKLEPGFQYCKGLHFWYTGEPNDALRHFNKARKDSDWGQNALYNMIEICLNPDNETIGGEVFENLNGDLGTSPEKQESVQLAVRTAEKLLKELKPQTVQGRLQLRIMENCCLMATKQKSSVEQALNTFTEIAASEKDHIPALLGMATAYMILKQTPKARNQLKRIAKMPWNPIEAEDLEKSWLLLADIYIQSAKYDMAEELLKRCLCHNRSCCKAYEYMGYIMEKEQAYTDAAFNYEMAWKHSNQTNPAVGYKLAFNYLKAKRYVDAIDVCHQVLEAHPTYPKIRKDILDKARASLRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
104	Ubiquitination	TKMKEQRKEAGRKAL HHHHHHHHHHHHHHH	52.16	-
311	Phosphorylation	LILQKVQSFLEKAFS HHHHHHHHHHHHHHC	34.48	23832136
478	Phosphorylation	SPVLRRCSSVLETII HHHHHHHHHHHHHHH	22.97	25168779
479	Phosphorylation	PVLRRCSSVLETIIR HHHHHHHHHHHHHHH	34.05	25168779
483	Phosphorylation	RCSSVLETIIRSVPG HHHHHHHHHHHHCCC	19.97	25168779
487	Phosphorylation	VLETIIRSVPGLPQA HHHHHHHHCCCCCHH	23.43	27180971
697	Phosphorylation	KEKMADIYLKHRKEK HHHHHHHHHHHCHHC	15.39	-
1047	Acetylation	DALRHFNKARKDSDW HHHHHHHHHCCCCCC	48.93	7844561
1206	Phosphorylation	WLLLADIYIQSAKYD HHHHHHHHHHHCCCC	8.08	26643407
1209	Phosphorylation	LADIYIQSAKYDMAE HHHHHHHHCCCCHHH	19.71	26643407
1211	Ubiquitination	DIYIQSAKYDMAEEL HHHHHHCCCCHHHHH	47.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TT21B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TT21B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TT21B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TT21B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.