TTL12_MOUSE - dbPTM
TTL12_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TTL12_MOUSE
UniProt AC Q3UDE2
Protein Name Tubulin--tyrosine ligase-like protein 12
Gene Name Ttll12 {ECO:0000312|MGI:MGI:3039573}
Organism Mus musculus (Mouse).
Sequence Length 639
Subcellular Localization
Protein Description
Protein Sequence MEIQSGPQPGSPGRAERLNARLLDEFVSLHGPTLRASGVPERLWGRLLHKLEHEVFDAGEMFGIMQVEEVEEAEDEAAREAQRKQPNPGGELCYKVIVTSESGVRADDPNSIFLIDHAWTCRVEHARKQLQQVPGLLHRMANLMGIEFHGEVPSPEVVALVLEEMWKFNQTYQLAHGTAEEKVPVWYIMDEFGSRIQHSDMPSFATAPFFYMPQQVAYTLLWPLRDLDTGEEVTRDFAYGEADPLIRKCMLLPWAPADMLDLSFSTPEPPAKYYQAILEENKEKLPLAISPVARPQGHVFRVHCDVQQVLGHLTHPRFTFTDSEADADIFFHFSHFKDYMKLSQESPQVLLNQFPCENLLTVKDCLASIARRAGGPEGPPWLPRTFNLRTELPQFVSYFQHRERRGEDNHWICKPWNLARSLDTHVTNNLHSIIRHRESTPKVVSKYIESPVLFLREDVGNVKFDIRYIVLLRSVRPLRLFAYDVFWLRFSNRPFALDDLDDYEKHFTVMNYDPDVVLKQVHYNEFIPQFEKQYPEFPWSDVQAEIFKAFTELFQVACAKPPPMGLCDYPSSRAMYAIDLMLNWDNHPDGKRVMQPQILEVNFNPDCERACRYHPSFFNDVFSTLFLDETDNCHVTRII
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MEIQSGPQPGSP
---CCCCCCCCCCCC		59.0926824392
11PhosphorylationQSGPQPGSPGRAERL
CCCCCCCCCCHHHHH		30.7526824392
93GlutathionylationPNPGGELCYKVIVTS
CCCCCCEEEEEEEEC		2.4124333276
290PhosphorylationEKLPLAISPVARPQG
HHCCCEEECCCCCCC		14.0228066266
421PhosphorylationKPWNLARSLDTHVTN
CHHHHHHHCCHHHHH		25.6230635358
424PhosphorylationNLARSLDTHVTNNLH
HHHHHCCHHHHHCHH		24.4430635358
427PhosphorylationRSLDTHVTNNLHSII
HHCCHHHHHCHHHHH		15.7030635358
432PhosphorylationHVTNNLHSIIRHRES
HHHHCHHHHHHCCCC		23.9119854140
450PhosphorylationVVSKYIESPVLFLRE
HHHHHHCCCEEEEEC		15.6828066266
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TTL12_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TTL12_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TTL12_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DNJB4_HUMANDNAJB4physical
20360068
TTL12_HUMANTTLL12physical
20360068
DNJB1_HUMANDNAJB1physical
20360068
IF4B_HUMANEIF4Bphysical
26496610
TPM1_HUMANTPM1physical
26496610
TYRO3_HUMANTYRO3physical
26496610
CBX3_HUMANCBX3physical
26496610
HSPB8_HUMANHSPB8physical
26496610
PTHB1_HUMANBBS9physical
26496610
OTU6B_HUMANOTUD6Bphysical
26496610
RT21_HUMANMRPS21physical
26496610
RM50_HUMANMRPL50physical
26496610
KLHL7_HUMANKLHL7physical
26496610
ZMYM1_HUMANZMYM1physical
26496610
PSRC1_HUMANPSRC1physical
26496610
PGAM5_HUMANPGAM5physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TTL12_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11, AND MASSSPECTROMETRY.

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