PLCE_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLCE_MOUSE
• UniProt AC: Q9D1E8
• Protein Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon
• Gene Name: Agpat5
• Organism: Mus musculus (Mouse).
• Sequence Length: 365
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. Mitochondrion.
• Protein Description: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable..
• Protein Sequence: MLLSLVLHTYSMRYLLPSVLLLGSAPTYLLAWTLWRVLSALMPARLYQRVDDRLYCVYQNMVLFFFENYTGVQILLYGDLPKNKENVIYLANHQSTVDWIVADMLAARQDALGHVRYVLKDKLKWLPLYGFYFAQHGGIYVKRSAKFNDKEMRSKLQSYVNAGTPMYLVIFPEGTRYNATYTKLLSASQAFAAQRGLAVLKHVLTPRIKATHVAFDSMKSHLDAIYDVTVVYEGNEKGSGKYSNPPSMTEFLCKQCPKLHIHFDRIDRNEVPEEQEHMKKWLHERFEIKDRLLIEFYDSPDPERRNKFPGKSVHSRLSVKKTLPSVLILGSLTAVMLMTESGRKLYMGTWLYGTLLGCLWFVIKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
183	Ubiquitination	RYNATYTKLLSASQA CCCCHHHHHHCHHHH	36.70	-
279	Acetylation	PEEQEHMKKWLHERF CHHHHHHHHHHHHHH	42.58	19847805
322	Phosphorylation	SRLSVKKTLPSVLIL HHHCCCCHHCCHHHH	37.88	25777480
325	Phosphorylation	SVKKTLPSVLILGSL CCCCHHCCHHHHHCH	32.44	25777480
331	Phosphorylation	PSVLILGSLTAVMLM CCHHHHHCHHHEECC	21.07	25777480
333	Phosphorylation	VLILGSLTAVMLMTE HHHHHCHHHEECCCC	20.92	25777480

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLCE_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLCE_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLCE_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PLCE_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.