LAMA1_MOUSE - dbPTM
LAMA1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LAMA1_MOUSE
UniProt AC P19137
Protein Name Laminin subunit alpha-1
Gene Name Lama1
Organism Mus musculus (Mouse).
Sequence Length 3084
Subcellular Localization Secreted, extracellular space, extracellular matrix, basement membrane. Major component.
Protein Description Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components..
Protein Sequence MRGSGTGAALLVLLASVLWVTVRSQQRGLFPAILNLATNAHISANATCGEKGPEMFCKLVEHVPGRPVRHAQCRVCDGNSTNPRERHPISHAIDGTNNWWQSPSIQNGREYHWVTVTLDLRQVFQVAYIIIKAANAPRPGNWILERSVDGVKFKPWQYYAVSDTECLTRYKITPRRGPPTYRADNEVICTSYYSKLVPLEHGEIHTSLINGRPSADDPSPQLLEFTSARYIRLRLQRIRTLNADLMTLSHRDLRDLDPIVTRRYYYSIKDISVGGMCICYGHASSCPWDEEAKQLQCQCEHNTCGESCDRCCPGYHQQPWRPGTISSGNECEECNCHNKAKDCYYDSSVAKERRSLNTAGQYSGGGVCVNCSQNTTGINCETCIDQYYRPHKVSPYDDHPCRPCNCDPVGSLSSVCIKDDRHADLANGKWPGQCPCRKGYAGDKCDRCQFGYRGFPNCIPCDCRTVGSLNEDPCIEPCLCKKNVEGKNCDRCKPGFYNLKERNPEGCSECFCFGVSGVCDSLTWSISQVTNMSGWLVTDLMSTNKIRSQQDVLGGHRQISINNTAVMQRLTSTYYWAAPEAYLGNKLTAFGGFLKYTVSYDIPVETVDSDLMSHADIIIKGNGLTISTRAEGLSLQPYEEYFNVVRLVPENFRDFNTRREIDRDQLMTVLANVTHLLIRANYNSAKMALYRLDSVSLDIASPNAIDLAVAADVEHCECPQGYTGTSCEACLPGYYRVDGILFGGICQPCECHGHASECDIHGICSVCTHNTTGDHCEQCLPGFYGTPSRGTPGDCQPCACPLSIDSNNFSPTCHLTDGEEVVCDQCAPGYSGSWCERCADGYYGNPTVPGGTCVPCNCSGNVDPLEAGHCDSVTGECLKCLWNTDGAHCERCADGFYGDAVTAKNCRACDCHENGSLSGVCHLETGLCDCKPHVTGQQCDQCLSGYYGLDTGLGCVPCNCSVEGSVSDNCTEEGQCHCGPGVSGKQCDRCSHGFYAFQDGGCTPCDCAHTQNNCDPASGECLCPPHTQGLKCEECEEAYWGLDPEQGCQACNCSAVGSTSAQCDVLSGHCPCKKGFGGQSCHQCSLGYRSFPDCVPCGCDLRGTLPDTCDLEQGLCSCSEDSGTCSCKENVVGPQCSKCQAGTFALRGDNPQGCSPCFCFGLSQLCSELEGYVRTLITLASDQPLLHVVSQSNLKGTIEGVHFQPPDTLLDAEAVRQHIYAEPFYWRLPKQFQGDQLLAYGGKLQYSVAFYSTLGTGTSNYEPQVLIKGGRARKHVIYMDAPAPENGVRQDYEVQMKEEFWKYFNSVSEKHVTHSDFMSVLSNIDYILIKASYGQGLQQSRIANISMEVGRKAVELPAEGEAALLLELCVCPPGTAGHSCQDCAPGYYREKLPESGGRGPRPLLAPCVPCNCNNHSDVCDPETGKCLSCRDHTSGDHCELCASGYYGKVTGLPGDCTPCTCPHHPPFSFSPTCVVEGDSDFRCNACLPGYEGQYCERCSAGYHGNPRAAGGSCQTCDCNPQGSVHSDCDRASGQCVCKPGATGLHCEKCLPRHILMESDCVSCDDDCVGPLLNDLDSVGDAVLSLNLTGVSPAPYGILENLENTTKYFQRYLIKENAKKIRAEIQLEGIAEQTENLQKELTRVLARHQKVNAEMERTSNGTQALATFIEQLHANIKEITEKVATLNQTARKDFQPPVSALQSMHQNISSLLGLIKERNFTEMQQNATLELKAAKDLLSRIQKRFQKPQEKLKALKEANSLLSNHSEKLQAAEELLKEAGSKTQESNLLLLLVKANLKEEFQEKKLRVQEEQNVTSELIAKGREWVDAAGTHTAAAQDTLTQLEHHRDELLLWARKIRSHVDDLVMQMSKRRARDLVHRAEQHASELQSRAGALDRDLENVRNVSLNATSAAHVHSNIQTLTEEAEMLAADAHKTANKTDLISESLASRGKAVLQRSSRFLKESVGTRRKQQGITMKLDELKNLTSQFQESVDNITKQANDSLAMLRESPGGMREKGRKARELAAAANESAVKTLEDVLALSLRVFNTSEDLSRVNATVQETNDLLHNSTMTTLLAGRKMKDMEMQANLLLDRLKPLKTLEENLSRNLSEIKLLISRARKQAASIKVAVSADRDCIRAYQPQTSSTNYNTLILNVKTQEPDNLLFYLGSSSSSDFLAVEMRRGKVAFLWDLGSGSTRLEFPEVSINNNRWHSIYITRFGNMGSLSVKEASAAENPPVRTSKSPGPSKVLDINNSTLMFVGGLGGQIKKSPAVKVTHFKGCMGEAFLNGKSIGLWNYIEREGKCNGCFGSSQNEDSSFHFDGSGYAMVEKTLRPTVTQIVILFSTFSPNGLLFYLASNGTKDFLSIELVRGRVKVMVDLGSGPLTLMTDRRYNNGTWYKIAFQRNRKQGLLAVFDAYDTSDKETKQGETPGAASDLNRLEKDLIYVGGLPHSKAVRKGVSSRSYVGCIKNLEISRSTFDLLRNSYGVRKGCALEPIQSVSFLRGGYVEMPPKSLSPESSLLATFATKNSSGILLVALGKDAEEAGGAQAHVPFFSIMLLEGRIEVHVNSGDGTSLRKALLHAPTGSYSDGQEHSISLVRNRRVITIQVDENSPVEMKLGPLTEGKTIDISNLYIGGLPEDKATPMLKMRTSFHGCIKNVVLDAQLLDFTHATGSEQVELDTCLLAEEPMQSLHREHGELPPEPPTLPQPELCAVDTAPGYVAGAHQFGLSQNSHLVLPLNQSDVRKRLQVQLSIRTFASSGLIYYVAHQNQMDYATLQLQEGRLHFMFDLGKGRTKVSHPALLSDGKWHTVKTEYIKRKAFMTVDGQESPSVTVVGNATTLDVERKLYLGGLPSHYRARNIGTITHSIPACIGEIMVNGQQLDKDRPLSASAVDRCYVVAQEGTFFEGSGYAALVKEGYKVRLDLNITLEFRTTSKNGVLLGISSAKVDAIGLEIVDGKVLFHVNNGAGRITATYQPRAARALCDGKWHTLQAHKSKHRIVLTVDGNSVRAESPHTHSTSADTNDPIYVGGYPAHIKQNCLSSRASFRGCVRNLRLSRGSQVQSLDLSRAFDLQGVFPHSCPGPEP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
25Pyrrolidone_carboxylic_acidLWVTVRSQQRGLFPA
HHHHHHHHHCCCHHH		26.82-
25Pyrrolidone_carboxylic_acidLWVTVRSQQRGLFPA
HHHHHHHHHCCCHHH		26.8211829758
25Pyrrolidone_carboxylic_acidLWVTVRSQQRGLFPA
HHHHHHHHHCCCHHH		26.8211829758
170PhosphorylationDTECLTRYKITPRRG
CCCCEEECCCCCCCC		11.0824719451
173PhosphorylationCLTRYKITPRRGPPT
CEEECCCCCCCCCCC		13.4424719451
370N-linked_GlycosylationSGGGVCVNCSQNTTG
CCCCEEEECCCCCCC		18.00-
493AcetylationGKNCDRCKPGFYNLK
CCCCCCCCCCCCCCC		49.412415041
672N-linked_GlycosylationQLMTVLANVTHLLIR
HHHHHHHHHHHHHHH		34.75-
1308PhosphorylationWKYFNSVSEKHVTHS
HHHHHHCCCCCCCHH		40.5227566939
1344N-linked_GlycosylationLQQSRIANISMEVGR
CCHHHHEEEEHHHCC		25.2119349973
1512PhosphorylationNPRAAGGSCQTCDCN
CCCCCCCCCCCCCCC		11.35-
1515PhosphorylationAAGGSCQTCDCNPQG
CCCCCCCCCCCCCCC		18.03-
1523PhosphorylationCDCNPQGSVHSDCDR
CCCCCCCCCCCCCCC		16.06-
1526PhosphorylationNPQGSVHSDCDRASG
CCCCCCCCCCCCCCC		37.47-
1659N-linked_GlycosylationAEMERTSNGTQALAT
HHEECCCCHHHHHHH		57.84-
1686N-linked_GlycosylationTEKVATLNQTARKDF
HHHHHHHHHHHHHHC		32.5719349973
1718N-linked_GlycosylationLGLIKERNFTEMQQN
HHHHHHCCCHHHHHH		49.6519349973
1725N-linked_GlycosylationNFTEMQQNATLELKA
CCHHHHHHHHHHHHH		20.2819349973
1763N-linked_GlycosylationEANSLLSNHSEKLQA
HHHHHHCHHHHHHHH		42.5519349973
1811N-linked_GlycosylationKLRVQEEQNVTSELI
HCHHHHHHCCCHHHH		49.28-
1935N-linked_GlycosylationAADAHKTANKTDLIS
HHHHHHHCCHHHHHH		21.9619349973
1936N-linked_GlycosylationADAHKTANKTDLISE
HHHHHHCCHHHHHHH		53.6519349973
1961AcetylationQRSSRFLKESVGTRR
HHHHHHHHHHHCCHH		45.2715216361
2026N-linked_GlycosylationARELAAAANESAVKT
HHHHHHHHCHHHHHH		18.6519349973
2027N-linked_GlycosylationRELAAAANESAVKTL
HHHHHHHCHHHHHHH		38.7419349973
2045N-linked_GlycosylationLALSLRVFNTSEDLS
HHHHHEEECCCHHHH		7.1619349973
2046N-linked_GlycosylationALSLRVFNTSEDLSR
HHHHEEECCCHHHHH		39.5819349973
2057PhosphorylationDLSRVNATVQETNDL
HHHHCCCCHHHHHHH		19.9526643407
2061PhosphorylationVNATVQETNDLLHNS
CCCCHHHHHHHCCHH		19.5526643407
2062N-linked_GlycosylationNATVQETNDLLHNST
CCCHHHHHHHCCHHH		36.8619349973
2066N-linked_GlycosylationQETNDLLHNSTMTTL
HHHHHHCCHHHHHHH		33.2319349973
2067N-linked_GlycosylationETNDLLHNSTMTTLL
HHHHHCCHHHHHHHH		38.8619349973
2068PhosphorylationTNDLLHNSTMTTLLA
HHHHCCHHHHHHHHC		14.6026643407
2069PhosphorylationNDLLHNSTMTTLLAG
HHHCCHHHHHHHHCC		24.6926643407
2071PhosphorylationLLHNSTMTTLLAGRK
HCCHHHHHHHHCCCC		17.8726643407
2072PhosphorylationLHNSTMTTLLAGRKM
CCHHHHHHHHCCCCC		14.6726643407
2355N-linked_GlycosylationGLLFYLASNGTKDFL
CEEEEEECCCCCCEE		32.95-
2516PhosphorylationPKSLSPESSLLATFA
CCCCCCHHHHHHHEE		29.66-
2517PhosphorylationKSLSPESSLLATFAT
CCCCCHHHHHHHEEC		26.2422817900
2524PhosphorylationSLLATFATKNSSGIL
HHHHHEECCCCCCEE		26.94-
2641PhosphorylationGLPEDKATPMLKMRT
CCCCCCCCCCHHCCC		18.2528059163
2751PhosphorylationKRLQVQLSIRTFASS
HHHHHHHHHHHHHHC		7.9222942356
2762PhosphorylationFASSGLIYYVAHQNQ
HHHCCCEEEEEECCC		9.2720116462
2763PhosphorylationASSGLIYYVAHQNQM
HHCCCEEEEEECCCC		5.5520116462
2834N-linked_GlycosylationSPSVTVVGNATTLDV
CCCEEEECCCEEEEC		17.4519349973
2835N-linked_GlycosylationPSVTVVGNATTLDVE
CCEEEECCCEEEECC		23.6219349973
2923N-linked_GlycosylationGYKVRLDLNITLEFR
CEEEEEEEEEEEEEE		6.21-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LAMA1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LAMA1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LAMA1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LAMB1_HUMANLAMB1physical
17517882
LAMC1_HUMANLAMC1physical
17517882
LAMB1_MOUSELamb1physical
9299121
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LAMA1_MOUSE

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1344; ASN-1686; ASN-1718;ASN-1725; ASN-1763; ASN-1936; ASN-2027; ASN-2046; ASN-2062; ASN-2067AND ASN-2835, AND MASS SPECTROMETRY.

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